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Persephin (PSP) Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691632

Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a… More details

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Product Overview

Online Datasheet in PDF
Product Name
Persephin (PSP), Active Protein
Full Product Name
Mouse Persephin (PSP)
Product Gene Name
PSP active protein
Product Synonym Names
Recombinant Murine Persephin (PSP)
Sequence
ALAGSCRLWS LTLPVAELGL GYASEEKVIF RYCAGSCPQE ARTQHS LVLA RLRGRGRAHG RPCCQPTSYA DVTFLDDQHH WQQLPQLSAA A CGCGG
Host
E Coli
Species Reactivity
Mouse
Form/Format
Lyophilized
Purity/Purification
> 98% by SDS-PAGE
Molecular Weight
20.6 kDa (Dimer)
Chromosome Location
Chromosome: 17; NC_000083.6 (56999457..57000018, complement). Location: 17 D; 17
3D Structure
ModBase 3D Structure for O70300
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng per ug of Persephin
Biological Activity
The ED50 was determined by its ability to stimulate proliferation of human thyroid carcinoma cells (TT cells) is < 0.1 ng/ml, corresponding to a specific activity of > 1 x 107 units/mg.

Product Categories/Family for PSP active protein

Cytokines & Growth Factors
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of PSP active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSP purchase

MBS691632 is an active protein targeting PSP. Also known as Mouse Persephin (PSP). Reactive in Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PSP. It may not necessarily be applicable to this product.

NCBI GI #
7531179
NCBI GeneID
19197
NCBI Accession #
O70300.1
UniProt Primary Accession #
O70300
UniProt Related Accession #
O70300
NCBI Official Full Name
Persephin
NCBI Official Synonym Full Names
persephin
NCBI Official Symbol
Pspn
NCBI Official Synonym Symbols
PSP
UniProt Protein Name
Persephin
Protein Family
Persephin
UniProt Gene Name
Pspn
UniProt Synonym Gene Names
PSP
UniProt Entry Name
PSPN_MOUSE
NCBI Protein Information
persephin

UniProt Comments for PSP

Function: Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.

Subunit structure: Homodimer; disulfide-linked

By similarity.

Subcellular location: Secreted.

Sequence similarities: Belongs to the TGF-beta family. GDNF subfamily.

Research Articles on PSP

1. TGF-beta with neurturin and persephin are required for the induction of dopaminergic neurons, whereas GDNF is required for regulating and/or maintaining a differentiated neuronal phenotype

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PSP active protein

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 NCAM1 Interactions Pathway antibodies  NCAM1 Interactions Pathway Diagram
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