Human ARTN Active Protein – Cat# MBS691701

Artemin (ARTN) Human Active Protein

Name: ARTN Active Protein; Artemin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS691701
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691701

Artemin is a disulfide-linked homodimeric neurotrophic factor structurally related to GDNF, Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. Artemin,… More details

$305 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Artemin (ARTN), Active Protein

Full Product Name

Human Artemin

Product Gene Name

ARTN active protein

Product Synonym Names

Recombinant Human Artemin

Sequence

AGGPGSRARA AGARGCRLRS QLVPVRALGL GHRSDELVRF RFCSGS CRRA RSPHDLSLAS LLGAGALRPP PGSRPVSQPC CRPTRYEAVS F MDVNSTWRT VDRLSATACG CLG

Host

E Coli

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

> 98% by SDS-PAGE and HPLC analyses

Molecular Weight

24.2 kDa

Chromosome Location

Chromosome: 1; NC_000001.11 (43933320..43937241). Location: 1p33-p32

OMIM

603886

3D Structure

ModBase 3D Structure for Q5T4W7

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng per ug of Artemin

Biological Activity

Determined by it\'s ability to promote survival and neurite outgrowth and dorsal root ganglion neurons.

Product Categories/Family for ARTN active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of ARTN active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARTN purchase

MBS691701 is an active protein targeting ARTN. Also known as Human Artemin. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ARTN. It may not necessarily be applicable to this product.

NCBI GI #

209977029

NCBI GeneID

9048

NCBI Accession #

NP_001129687.1

UniProt Primary Accession #

Q5T4W7

UniProt Secondary Accession #

O95441; O96030; Q6P6A3; D3DPY1; D3DPY3

UniProt Related Accession #

Q5T4W7

GenBank Nucleotide #

NM_001136215.1

NCBI Official Full Name

artemin isoform 3

NCBI Official Synonym Full Names

artemin

NCBI Official Symbol

ARTN

NCBI Official Synonym Symbols

EVN; NBN; ENOVIN

UniProt Protein Name

Artemin

UniProt Synonym Protein Names

Enovin; Neublastin

Protein Family

Artemin

UniProt Gene Name

ARTN

UniProt Synonym Gene Names

EVN

UniProt Entry Name

ARTN_HUMAN

NCBI Protein Information

artemin; neublastin; neurotrophic factor

NCBI Summary for ARTN

The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

UniProt Comments for ARTN

Function: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Ref.1 Ref.2

Subunit structure: Homodimer; disulfide-linked. Binds to RET

By similarity. Ref.8

Subcellular location: Secreted

By similarity.

Tissue specificity: Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta, pancreas, heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain. Ref.1 Ref.2

Developmental stage: Expressed during embryogenesis. High level expression seen in fetal kidney and lung while a low level expression seen in the fetal brain. Ref.1

Sequence similarities: Belongs to the TGF-beta family. GDNF subfamily.

Research Articles on ARTN

1. The expression of GFRalpha1 and/or GFRalpha3, especially when combined with ARTN expression, may be useful predictors of disease progression and outcome in specific subtypes of mammary carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ARTN active protein

Reference Product	PubMed Publications
GDNF active protein	>74 publications with ARTN and GDNF
NRTN active protein	>22 publications with ARTN and NRTN
GFRA3 active protein	>19 publications with ARTN and GFRA3
PSPN active protein	>9 publications with ARTN and PSPN
GFRA1 active protein	>8 publications with ARTN and GFRA1
TRIM27 active protein	>1 publications with ARTN and TRIM27
RAC1 active protein	>1 publications with ARTN and RAC1
NCAM1 active protein	>1 publications with ARTN and NCAM1

Pathways associated with ARTN active protein

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
NCAM Signaling For Neurite Out-growth Pathway antibodies	NCAM Signaling For Neurite Out-growth Pathway Diagram
NCAM1 Interactions Pathway antibodies	NCAM1 Interactions Pathway Diagram

Diseases associated with ARTN active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>25 publications with ARTN and Nervous System Diseases
Neoplasms Antibodies	>17 publications with ARTN and Neoplasms
Breast Neoplasms Antibodies	>6 publications with ARTN and Breast Neoplasms
Adenocarcinoma Antibodies	>5 publications with ARTN and Adenocarcinoma
Pancreatic Neoplasms Antibodies	>4 publications with ARTN and Pancreatic Neoplasms
Lung Neoplasms Antibodies	>3 publications with ARTN and Lung Neoplasms
Hypertrophy Antibodies	>3 publications with ARTN and Hypertrophy
Inflammation Antibodies	>3 publications with ARTN and Inflammation
Cardiovascular Diseases Antibodies	>2 publications with ARTN and Cardiovascular Diseases
Ischemia Antibodies	>2 publications with ARTN and Ischemia

Organs/Tissues associated with ARTN active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>21 publications with ARTN and Brain
Pancreas Antibodies	>4 publications with ARTN and Pancreas
Kidney Antibodies	>4 publications with ARTN and Kidney
Intestine Antibodies	>4 publications with ARTN and Intestine
Lung Antibodies	>4 publications with ARTN and Lung
Esophagus Antibodies	>1 publications with ARTN and Esophagus