Human MIP-1 alpha (CCL3) Active Protein – Cat# MBS691708

MIP-1 alpha (CCL3) Human Active Protein

Name: MIP-1 alpha (CCL3) Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS691708
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691708

Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups… More details

$305 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MIP-1 alpha (CCL3), Active Protein

Full Product Name

Human MIP-1 alpha (CCL3)

Product Gene Name

MIP-1 alpha (CCL3) active protein

Product Synonym Names

Recombinant Human MIP-1 alpha

Sequence

ASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKR SRQV CADPSEEWVQ KYVSDLELSA

Host

E Coli

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

> 99% by SDS-PAGE and HPLC analysis

Molecular Weight

7.8 kDa

Chromosome Location

Chromosome: 17; NC_000017.11 (36088256..36090160, complement). Location: 17q12

OMIM

182283

3D Structure

ModBase 3D Structure for P10147

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng per ug of MIP-1 alpha

Biological Activity

Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ng/ml.

Product Categories/Family for MIP-1 alpha (CCL3) active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of MIP-1 alpha (CCL3) active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIP-1 alpha (CCL3) purchase

MBS691708 is an active protein targeting MIP-1 alpha (CCL3). Also known as Human MIP-1 alpha (CCL3). Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP-1 alpha (CCL3). It may not necessarily be applicable to this product.

NCBI GI #

4506843

NCBI GeneID

6348

NCBI Accession #

NP_002974.1

UniProt Primary Accession #

P10147

UniProt Related Accession #

P10147

GenBank Nucleotide #

NM_002983.2

NCBI Official Full Name

C-C motif chemokine 3

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 3

NCBI Official Symbol

CCL3

NCBI Official Synonym Symbols

MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha

UniProt Protein Name

C-C motif chemokine 3

UniProt Synonym Protein Names

G0/G1 switch regulatory protein 19-1; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; PAT 464.1; SIS-beta; Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha proteinCleaved into the following chain:MIP-1-alpha(4-69); Alternative name(s):; LD78-alpha(4-69)

UniProt Gene Name

CCL3

UniProt Synonym Gene Names

G0S19-1; MIP1A; SCYA3; MIP-1-alpha

UniProt Entry Name

CCL3_HUMAN

NCBI Protein Information

C-C motif chemokine 3; SIS-beta; PAT 464.1; G0/G1 switch regulatory protein 19-1; macrophage inflammatory protein 1-alpha; tonsillar lymphocyte LD78 alpha protein; small inducible cytokine A3 (homologous to mouse Mip-1a)

NCBI Summary for MIP-1 alpha (CCL3)

This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]

UniProt Comments for MIP-1 alpha (CCL3)

Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Ref.8

Subunit structure: Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). Ref.11

Subcellular location: Secreted.

Induction: By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)).

Post-translational modification: N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

Research Articles on MIP-1 alpha (CCL3)

1. the role of Tax2-mediated activation of the nuclear factor kappa B (NF-kappaB) signalling pathway on the production of the anti-viral CC-chemokines MIP-1alpha, MIP-1beta and RANTES.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MIP-1 alpha (CCL3) active protein

Reference Product	PubMed Publications
CCL4 active protein	>1566 publications with MIP-1 alpha (CCL3) and CCL4
CCR5 active protein	>489 publications with MIP-1 alpha (CCL3) and CCR5
CCR1 active protein	>269 publications with MIP-1 alpha (CCL3) and CCR1
CCR2 active protein	>130 publications with MIP-1 alpha (CCL3) and CCR2
CCR3 active protein	>66 publications with MIP-1 alpha (CCL3) and CCR3
CCR4 active protein	>44 publications with MIP-1 alpha (CCL3) and CCR4
IL18 active protein	>17 publications with MIP-1 alpha (CCL3) and IL18
IL1B active protein	>11 publications with MIP-1 alpha (CCL3) and IL1B
IDE active protein	>5 publications with MIP-1 alpha (CCL3) and IDE
CXCR5 active protein	>4 publications with MIP-1 alpha (CCL3) and CXCR5

Pathways associated with MIP-1 alpha (CCL3) active protein

Products by Pathway	Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
IL12-mediated Signaling Events Pathway antibodies	IL12-mediated Signaling Events Pathway Diagram

Diseases associated with MIP-1 alpha (CCL3) active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>796 publications with MIP-1 alpha (CCL3) and Inflammation
Necrosis Antibodies	>468 publications with MIP-1 alpha (CCL3) and Necrosis
Disease Models, Animal Antibodies	>287 publications with MIP-1 alpha (CCL3) and Disease Models, Animal
Lung Diseases Antibodies	>221 publications with MIP-1 alpha (CCL3) and Lung Diseases
HIV Infections Antibodies	>184 publications with MIP-1 alpha (CCL3) and HIV Infections
Cardiovascular Diseases Antibodies	>156 publications with MIP-1 alpha (CCL3) and Cardiovascular Diseases
Hypersensitivity Antibodies	>100 publications with MIP-1 alpha (CCL3) and Hypersensitivity
Liver Diseases Antibodies	>83 publications with MIP-1 alpha (CCL3) and Liver Diseases
Pneumonia Antibodies	>67 publications with MIP-1 alpha (CCL3) and Pneumonia
Fibrosis Antibodies	>66 publications with MIP-1 alpha (CCL3) and Fibrosis

Organs/Tissues associated with MIP-1 alpha (CCL3) active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1441 publications with MIP-1 alpha (CCL3) and Blood
Lung Antibodies	>303 publications with MIP-1 alpha (CCL3) and Lung
Brain Antibodies	>235 publications with MIP-1 alpha (CCL3) and Brain
Liver Antibodies	>196 publications with MIP-1 alpha (CCL3) and Liver
Kidney Antibodies	>77 publications with MIP-1 alpha (CCL3) and Kidney
Heart Antibodies	>73 publications with MIP-1 alpha (CCL3) and Heart
Intestine Antibodies	>51 publications with MIP-1 alpha (CCL3) and Intestine
Eye Antibodies	>47 publications with MIP-1 alpha (CCL3) and Eye
Placenta Antibodies	>17 publications with MIP-1 alpha (CCL3) and Placenta
Uterus Antibodies	>17 publications with MIP-1 alpha (CCL3) and Uterus