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IL-3 beta Rat Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691777

IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast… More details

$305 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-3 beta, Active Protein
Full Product Name
Rat IL-3 beta
Product Gene Name
IL-3 beta active protein
Product Synonym Names
Recombinant Rat IL-3 beta
Sequence
MISDRGSDAH HLLRTLDCRT IALEILVKLP YPQVSGLNNS DDKANL RNST LRRVNLDEFL KSQEEFDSQD TTDIKSKLQK LKCCIPAAAS D SVLPGVYNK DLDDFKKKLR FYVIHLKDLQ PVSVSRPPQP TSSSDNF RPM TVEC
Host
E Coli
Species Reactivity
Rat
Form/Format
Lyophilized
Purity/Purification
> 98% by SDS-PAGE and HPLC analysis
Molecular Weight
16.3 kDa
Chromosome Location
Chromosome: 3; NC_005102.3 (128133929..128140354). Location: 3q36
3D Structure
ModBase 3D Structure for Q63264
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng/ug of IL-3 beta
Biological Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of thymidine uptake by murine MC-9 cells is < 10 ng/ml, corresponding to a specific activity of >1.0 x 105 units/mg.

Product Categories/Family for IL-3 beta active protein

Cytokines & Growth Factors
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of IL-3 beta active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-3 beta purchase

MBS691777 is an active protein targeting IL-3 beta. Also known as Rat IL-3 beta. Reactive in Rat. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-3 beta. It may not necessarily be applicable to this product.

NCBI GI #
2497335
NCBI GeneID
24494
NCBI Accession #
Q63264.1
UniProt Primary Accession #
Q63264
UniProt Related Accession #
Q63264
NCBI Official Full Name
Interleukin-1 beta
NCBI Official Synonym Full Names
interleukin 1 beta
NCBI Official Symbol
Il1b
UniProt Protein Name
Interleukin-1 beta
Protein Family
Invertase
UniProt Gene Name
Il1b
UniProt Synonym Gene Names
IL-1 beta
UniProt Entry Name
IL1B_RAT
NCBI Protein Information
interleukin-1 beta; IL-1 beta

NCBI Summary for IL-3 beta

an inflammatory cytokine [RGD, Feb 2006]

UniProt Comments for IL-3 beta

Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Subunit structure: Monomer.

Subcellular location: Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similarities: Belongs to the IL-1 family.
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Research Articles on IL-3 beta

1. Cytochrome P450 family 2 subfamily polypeptide (CYP2C22) is rapidly downregulated in primary rat hepatocytes by IL-1beta or nitric oxide-donating compounds.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IL-3 beta active protein

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 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram

Organs/Tissues associated with IL-3 beta active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >59 publications with IL-3 beta and Lung
 Liver Antibodies  >28 publications with IL-3 beta and Liver
 Kidney Antibodies  >20 publications with IL-3 beta and Kidney
 Eye Antibodies  >15 publications with IL-3 beta and Eye
 Ovary Antibodies  >14 publications with IL-3 beta and Ovary
 Spleen Antibodies  >7 publications with IL-3 beta and Spleen
 Connective Tissue Antibodies  >7 publications with IL-3 beta and Connective Tissue
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