Rat G-CSF Active Protein – Cat# MBS691792

G-CSF Rat Active Protein

Name: G-CSF Active Protein; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS691792
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691792

G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells… More details

$305 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

G-CSF, Active Protein

Full Product Name

Rat G-CSF

Product Gene Name

G-CSF active protein

Product Synonym Names

Granulocyte Colony-Stimulating Factor; CSF-3; MGI-1G; GM-CSFbeta; pluripoietin; Granulocyte Colony-Stimulating Factor; CSF-3; MGI-1G; GM-CSFbeta; pluripoietin

Sequence

MKKIPLLTVS SLPPSLPLPR SFLLKSLEQV RKIQARNTEL LEQLCA TYKL CHPEELVLFG HSLGIPKASL SSCSSQALQQ TKCLSQLHSG L FLYQGLLQA LAGISSELAP TLDMLHLDVD NFATTIWQQM ESLGVAP TVQ PTQSTMPIFT SAFQRRAGGV LVTSYLQSFL ETAHHALHHL PR PAQKHFPE SLFISI

Host

E Coli

Species Reactivity

Rat

Form/Format

Lyophilized

Purity/Purification

> 98% by SDS-PAGE & HPLC analyses

Molecular Weight

23,660 Da

Chromosome Location

Chromosome: 10; NC_005109.3 (86413088..86415478). Location: 10q31

3D Structure

ModBase 3D Structure for P97712

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by its ability to stimulate the proliferation of mouse NFS-60 cells. The expected ED50 is <= 0.05 ng/ml, corresponding to a specific activity of >= 2 x 107 units/mg.

Product Categories/Family for G-CSF active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of G-CSF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for G-CSF purchase

MBS691792 is an active protein targeting G-CSF. Also known as Rat G-CSF. Reactive in Rat. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for G-CSF. It may not necessarily be applicable to this product.

NCBI GI #

8393200

NCBI GeneID

25610

NCBI Accession #

NP_058800.1

UniProt Primary Accession #

P97712

GenBank Nucleotide #

NM_017104.1

NCBI Official Full Name

granulocyte colony-stimulating factor

NCBI Official Synonym Full Names

colony stimulating factor 3 (granulocyte)

NCBI Official Symbol

Csf3

NCBI Official Synonym Symbols

Gcsf

UniProt Protein Name

Granulocyte colony stimulating factor

Protein Family

Granulocyte colony-stimulating factor receptor

UniProt Gene Name

Csf3

UniProt Entry Name

P97712_RAT

NCBI Protein Information

granulocyte colony-stimulating factor

NCBI Summary for G-CSF

putative hematopoetic growth factor for neutrophils; used as a treatment for cyclic hematopoesis in humans and dogs [RGD, Feb 2006]

UniProt Comments for G-CSF

G-CSF: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cytokine; Secreted, signal peptide; Cell cycle regulation

Cellular Component: extracellular space

Molecular Function: enzyme binding; growth factor activity; cytokine activity

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of myeloid cell differentiation; positive regulation of actin filament polymerization; positive regulation of protein binding; positive regulation of cell proliferation; positive regulation of transcription factor import into nucleus; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation

Research Articles on G-CSF

1. In conclusion, G-CSF induced LBP expression could serve as a new model for investigation of LPS sensitization. We demonstrated the crucial role of LBP upregulation in pathogenesis of LPS induced SIRS.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with G-CSF active protein

Reference Product	PubMed Publications
Csf2 active protein	>17 publications with G-CSF and Csf2
Csf3r active protein	>12 publications with G-CSF and Csf3r
Kitlg active protein	>6 publications with G-CSF and Kitlg
Cxcl12 active protein	>3 publications with G-CSF and Cxcl12
Socs3 active protein	>2 publications with G-CSF and Socs3
Nos2 active protein	>1 publications with G-CSF and Nos2
Sell active protein	>1 publications with G-CSF and Sell

Pathways associated with G-CSF active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response (BioCarta) Pathway antibodies	Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram

Diseases associated with G-CSF active protein

Disease Name	Pubmed Publications
Disease Susceptibility Antibodies	>6 publications with G-CSF and Disease Susceptibility
Nervous System Diseases Antibodies	>4 publications with G-CSF and Nervous System Diseases
Neutropenia Antibodies	>3 publications with G-CSF and Neutropenia
Leukopenia Antibodies	>2 publications with G-CSF and Leukopenia
Anemia Antibodies	>2 publications with G-CSF and Anemia
Leukemia, Myeloid, Acute Antibodies	>2 publications with G-CSF and Leukemia, Myeloid, Acute
Breast Neoplasms Antibodies	>1 publications with G-CSF and Breast Neoplasms
Peripheral Nervous System Diseases Antibodies	>1 publications with G-CSF and Peripheral Nervous System Diseases
Pulmonary Fibrosis Antibodies	>1 publications with G-CSF and Pulmonary Fibrosis
Brain Injuries Antibodies	>1 publications with G-CSF and Brain Injuries