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Follistatin (FST) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691793

Follistatin belongs to a group of structurally-diverse diffusible proteins that binds to TGF-beta ligands and inhibit their activity by hindering access to signaling receptors. This naturally occurring antagonist binds to Activin, BMP-2,-4,-6,-7, Myostatin,… More details

$305 / 0.005 mg +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Follistatin (FST), Active Protein
Full Product Name
Human Follistatin
Product Gene Name
Product Synonym Names
Recombinant Human Follistatin
Sequence
GNCWLRQAKN GRCQVLYKTE LSKEECCSTG RLSTSWTEED VNDNTL FKWM IFNGGAPNCI PCKETCENVD CGPGKKCRMN KKNKPRCVCA P DCSNITWKG PVCGLDGKTY RNECALLKAR CKEQPELEVQ YQGRCKK TCR DVFCPGSSTC VVDQTNNAYC VTCNRICPEP ASSEQYLCGN DG VTYSSACH LRKATCLLGR SIGLAYEGKC IKAKSCEDIQ CTGGKKCL WD FKVGRGRCSL CDELCPDSKS DEPVCASDNA TYASECAMKE AAC SSGVLLE VKHSGSCN
Host
E Coli
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
> 96% by SDS-PAGE and HPLC analysis
Molecular Weight
31.5 kDa
Chromosome Location
Chromosome: 5; NC_000005.10 (53480355..53487134). Location: 5q11.2
OMIM
136470
3D Structure
ModBase 3D Structure for P19883
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng per ug of Follistatin
Biological Activity
Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.1-0.4 ug/ml in the presence of 7.5 ng/ml Activin A.

Product Categories/Family for FST active protein

ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of FST active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FST purchase

MBS691793 is an active protein targeting FST. Also known as Human Follistatin. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FST. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
follistatin isoform FST317
NCBI Official Synonym Full Names
follistatin
NCBI Official Symbol
FST
NCBI Official Synonym Symbols
FS
UniProt Protein Name
Follistatin
UniProt Synonym Protein Names
Activin-binding protein
Protein Family
UniProt Gene Name
FST
UniProt Synonym Gene Names
FS
UniProt Entry Name
FST_HUMAN
NCBI Protein Information
follistatin; activin-binding protein; follistatin isoform FST317

NCBI Summary for FST

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
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UniProt Comments for FST

Function: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

Subunit structure: Monomer

Potential.

Subcellular location: Secreted.

Tissue specificity: Isoform 1 is the predominant isoform inserum but is undetectable in follicular fluid. Ref.6

Sequence similarities: Contains 3 follistatin-like domains.Contains 3 Kazal-like domains.Contains 1 TB (TGF-beta binding) domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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