Human IL-17A Active Protein – Cat# MBS691803

IL-17A Human Active Protein

Name: IL-17A Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS691803
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691803

The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17… More details

$305 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL-17A, Active Protein

Full Product Name

Human IL-17A

Product Gene Name

IL-17A active protein

Product Synonym Names

IL17A; IL17; CTLA8; IL-17; IL-17A

Sequence

MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSS DYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY H MNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA

Host

E Coli

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

> 98% by SDS-PAGE and HPLC analyses

Preparation and Storage

Stability:
The lyophilized protein is stable at room temperature for 1 month and 4 degree C for 6 months. Reconstituted working aliquots are stable for 1 week at 2 degree C to 8 degree C and for 10 months at -20 degree C to -80 degree C.
Reconstitution:
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/m. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at 20 degree C – 80 degree C.
Avoid repeated freeze/thaw cycyles.

Molecular Weight

31.3 kDa

Chromosome Location

Chromosome: 6; NC_000006.12 (52186387..52190638). Location: 6p12

OMIM

603149

3D Structure

ModBase 3D Structure for Q16552

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Structural Information

disulphide-linked homodimer.

Endotoxin Level

< 0.1 ng/ug of protein (<1EU/ug)

Biological Activity

Measured by its ability to induce IL-6 production by NHDF cells, using a concentration range of 0.5-1.5 ng/ml

Product Categories/Family for IL-17A active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of IL-17A active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-17A purchase

MBS691803 is an active protein targeting IL-17A. Also known as Human IL-17A. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-17A. It may not necessarily be applicable to this product.

NCBI GI #

4504651

NCBI GeneID

3605

NCBI Accession #

NP_002181.1

UniProt Primary Accession #

Q16552

UniProt Secondary Accession #

Q5T2P0

UniProt Related Accession #

Q16552

GenBank Nucleotide #

NM_002190.2

NCBI Official Full Name

interleukin-17A

NCBI Official Synonym Full Names

interleukin 17A

NCBI Official Symbol

IL17A

NCBI Official Synonym Symbols

IL17; CTLA8; IL-17; IL-17A

UniProt Protein Name

Interleukin-17A

UniProt Synonym Protein Names

Cytotoxic T-lymphocyte-associated antigen 8

Protein Family

Interleukin

UniProt Gene Name

IL17A

UniProt Synonym Gene Names

CTLA8; IL17; IL-17; IL-17A; CTLA-8

UniProt Entry Name

IL17_HUMAN

NCBI Protein Information

interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

NCBI Summary for IL-17A

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

UniProt Comments for IL-17A

Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.

Subunit structure: Homodimer. Ref.8

Subcellular location: Secreted.

Tissue specificity: Restricted to activated memory T-cells.

Post-translational modification: Found both in glycosylated and nonglycosylated forms.

Sequence similarities: Belongs to the IL-17 family.

Research Articles on IL-17A

1. These findings have established a compelling linkage between activated IL-17-mediated polarization of M1 macrophages and the development of BRONJ-like conditions in both human disease and murine models.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL-17A active protein

Reference Product	PubMed Publications
FOXP3 active protein	>578 publications with IL-17A and FOXP3
STAT3 active protein	>238 publications with IL-17A and STAT3
TGFB1 active protein	>123 publications with IL-17A and TGFB1
IL17RA active protein	>99 publications with IL-17A and IL17RA
IL6 active protein	>91 publications with IL-17A and IL6
STAT1 active protein	>76 publications with IL-17A and STAT1
IL23A active protein	>61 publications with IL-17A and IL23A
IL17RC active protein	>18 publications with IL-17A and IL17RC
NFKB1 active protein	>1 publications with IL-17A and NFKB1

Pathways associated with IL-17A active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
IL17 Signaling Pathway antibodies	IL17 Signaling Pathway Diagram
IL23-mediated Signaling Events Pathway antibodies	IL23-mediated Signaling Events Pathway Diagram
IL27-mediated Signaling Events Pathway antibodies	IL27-mediated Signaling Events Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
TCR Signaling Pathway antibodies	TCR Signaling Pathway Diagram

Diseases associated with IL-17A active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>2054 publications with IL-17A and Inflammation
Autoimmune Diseases Antibodies	>1642 publications with IL-17A and Autoimmune Diseases
Disease Models, Animal Antibodies	>1155 publications with IL-17A and Disease Models, Animal
Necrosis Antibodies	>851 publications with IL-17A and Necrosis
Nervous System Diseases Antibodies	>636 publications with IL-17A and Nervous System Diseases
Respiratory Tract Diseases Antibodies	>592 publications with IL-17A and Respiratory Tract Diseases
Lung Diseases Antibodies	>515 publications with IL-17A and Lung Diseases
Central Nervous System Diseases Antibodies	>490 publications with IL-17A and Central Nervous System Diseases
Hypersensitivity Antibodies	>425 publications with IL-17A and Hypersensitivity
Liver Diseases Antibodies	>155 publications with IL-17A and Liver Diseases

Organs/Tissues associated with IL-17A active protein

Organ/Tissue Name	Pubmed Publications
Mixed Antibodies	>89 publications with IL-17A and Mixed