Mouse MIP-3 beta (CCL19) Active Protein – Cat# MBS691881

MIP-3 beta (CCL19) Mouse Active Protein

Name: MIP-3 beta (CCL19) Active Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS691881
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691881

MIP-3beta is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3beta is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3beta is… More details

$305 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MIP-3 beta (CCL19), Active Protein

Full Product Name

Mouse MIP-3 beta (CCL19)

Product Gene Name

MIP-3 beta (CCL19) active protein

Product Synonym Names

Recombinant Murine MIP-3 beta (CCL19)

Sequence

GANDAEDCCL SVTQRPIPGN IVKAFRYLLN EDGCRVPAVV FTTLRG YQLC APPDQPWVDR IIRRLKKSSA KNKGNSTRRS PVS

Host

E Coli

Species Reactivity

Mouse

Form/Format

Lyophilized

Purity/Purification

> 98% by SDS-PAGE and HPLC analysis

Molecular Weight

9.2 kDa

Chromosome Location

Chromosome: 4; NC_000070.6 (42754525..42756518, complement). Location: 4 A5; 4

3D Structure

ModBase 3D Structure for O70460

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng per ug of CCL19

Biological Activity

Determined by its ability to chemoattract human mature dendritic cells using a concentration range of 10.0-100.0 ng/ml.

Product Categories/Family for MIP-3 beta (CCL19) active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of MIP-3 beta (CCL19) active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIP-3 beta (CCL19) purchase

MBS691881 is an active protein targeting MIP-3 beta (CCL19). Also known as Mouse MIP-3 beta (CCL19). Reactive in Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP-3 beta (CCL19). It may not necessarily be applicable to this product.

NCBI GI #

6755422

NCBI GeneID

24047

NCBI Accession #

NP_036018.1

UniProt Primary Accession #

O70460

UniProt Related Accession #

O70460

GenBank Nucleotide #

NM_011888.2

NCBI Official Full Name

C-C motif chemokine 19

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 19

NCBI Official Symbol

Ccl19

NCBI Official Synonym Symbols

ELC; CKb11; MIP3B; Scya19; exodus-3

UniProt Protein Name

C-C motif chemokine 19

UniProt Synonym Protein Names

Epstein-Barr virus-induced molecule 1 ligand chemokine; EBI1 ligand chemokine; ELC; Small-inducible cytokine A19

UniProt Gene Name

Ccl19

UniProt Synonym Gene Names

Elc; Scya19; EBI1 ligand chemokine; ELC

UniProt Entry Name

CCL19_MOUSE

NCBI Protein Information

C-C motif chemokine 19; chemokine CCL19; EBI1 ligand chemokine; EBI1-ligand chemokine; EBI-1 ligand chemokine; small inducible cytokine A19; small-inducible cytokine A19; EBV-induced molecule 1 ligand chemokine; epstein-Barr virus-induced molecule 1 ligand chemokine

UniProt Comments for MIP-3 beta (CCL19)

Function: Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Subcellular location: Secreted.

Tissue specificity: Highly expressed by dendritic cells in mesenteric and peripheral lymph nodes. Significant expression in spleen (T cell zone or periarteriolar lymphatic sheath) and Peyer patches. Low expression in thymus.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

Research Articles on MIP-3 beta (CCL19)

1. CCL19 (ELC) improves TH1-polarized immune responses and protective immunity in a murine Her2/neu DNA vaccination model.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MIP-3 beta (CCL19) active protein

Reference Product	PubMed Publications
Ccr7 active protein	>404 publications with MIP-3 beta (CCL19) and Ccr7
Cxcl12 active protein	>124 publications with MIP-3 beta (CCL19) and Cxcl12
Cxcl13 active protein	>95 publications with MIP-3 beta (CCL19) and Cxcl13
Ccr6 active protein	>45 publications with MIP-3 beta (CCL19) and Ccr6
Cxcl9 active protein	>35 publications with MIP-3 beta (CCL19) and Cxcl9
Cxcr5 active protein	>31 publications with MIP-3 beta (CCL19) and Cxcr5
Ccl17 active protein	>29 publications with MIP-3 beta (CCL19) and Ccl17
Cxcr3 active protein	>25 publications with MIP-3 beta (CCL19) and Cxcr3
Ccl25 active protein	>24 publications with MIP-3 beta (CCL19) and Ccl25

Pathways associated with MIP-3 beta (CCL19) active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram

Diseases associated with MIP-3 beta (CCL19) active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>136 publications with MIP-3 beta (CCL19) and Inflammation
Neoplasms Antibodies	>107 publications with MIP-3 beta (CCL19) and Neoplasms
Necrosis Antibodies	>63 publications with MIP-3 beta (CCL19) and Necrosis
Lung Diseases Antibodies	>39 publications with MIP-3 beta (CCL19) and Lung Diseases
Vascular Diseases Antibodies	>26 publications with MIP-3 beta (CCL19) and Vascular Diseases
Hypersensitivity Antibodies	>26 publications with MIP-3 beta (CCL19) and Hypersensitivity
Carcinoma, Squamous Cell Antibodies	>17 publications with MIP-3 beta (CCL19) and Carcinoma, Squamous Cell
Neoplasms, Experimental Antibodies	>15 publications with MIP-3 beta (CCL19) and Neoplasms, Experimental
Liver Diseases Antibodies	>13 publications with MIP-3 beta (CCL19) and Liver Diseases
Respiratory Tract Infections Antibodies	>13 publications with MIP-3 beta (CCL19) and Respiratory Tract Infections

Organs/Tissues associated with MIP-3 beta (CCL19) active protein

Organ/Tissue Name	Pubmed Publications
Spleen Antibodies	>67 publications with MIP-3 beta (CCL19) and Spleen
Bone Marrow Antibodies	>65 publications with MIP-3 beta (CCL19) and Bone Marrow
Skin Antibodies	>63 publications with MIP-3 beta (CCL19) and Skin
Lung Antibodies	>56 publications with MIP-3 beta (CCL19) and Lung
Thymus Antibodies	>36 publications with MIP-3 beta (CCL19) and Thymus
Brain Antibodies	>27 publications with MIP-3 beta (CCL19) and Brain
Muscle Antibodies	>22 publications with MIP-3 beta (CCL19) and Muscle
Intestine Antibodies	>21 publications with MIP-3 beta (CCL19) and Intestine
Eye Antibodies	>19 publications with MIP-3 beta (CCL19) and Eye
Kidney Antibodies	>18 publications with MIP-3 beta (CCL19) and Kidney