GASP-1 Human Active Protein

This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]

Function: Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN1P1/BECN2. Ref.5 Ref.6 Ref.8

Subunit structure: Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine receptor/DRD2

By similarity, delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4. Interacts with PER1. Interacts with BECN1P1/BECN2; the interaction is direct. Ref.5 Ref.6 Ref.7 Ref.8

Subcellular location: Cytoplasm Ref.6.

Tissue specificity: Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra. Ref.5 Ref.7

Sequence similarities: Belongs to the GPRASP family.

Sequence caution: The sequence BAA23715.3 differs from that shown. Reason: Erroneous initiation.