• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

IL-1 beta Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS692005

Interleukin-1 beta (IL-1beta) is produced by activated macrophages. IL-1beta stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1beta proteins are involved in the… More details

$355 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-1 beta, Active Protein
Full Product Name
Human IL-1 beta
Product Gene Name
IL-1 beta active protein
Product Synonym Names
Recombinant Human Interleukin-1 beta; Catabolin; IL1F2
Sequence
N-Terminal Sequence: APVRSL and MAPVRS
Host
E Coli
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
> 98% by SDS-PAGE & silver stain
Preparation and Storage
Lyophilized IL-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL-1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.
Molecular Weight
17.0Da
Chromosome Location
Chromosome: 2; NC_000002.12 (112829751..112836779, complement). Location: 2q14
OMIM
147720
3D Structure
ModBase 3D Structure for P01584
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1ng per ug (IEU/ug) of rh IL-1 beta
Buffer
PBS

Product Categories/Family for IL-1 beta active protein

Cytokines & Growth Factors
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Testing Data of IL-1 beta active protein

Human IL-1 beta Active Protein – Cat# MBS692005

Testing Data #2 of IL-1 beta active protein

Human IL-1 beta Active Protein, Testing Data #2 – Cat# MBS692005

Product References and Citations for IL-1 beta active protein

1. Allan, S.M. et al. (2005) Nat. Rev. Immunol. 5:629. 2. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229. 3. Kornman, K.S. (2006) Am. J. Clin. Nutr. 83:475S. 4. Isoda, K. and F. Ohsuzu (2006) J. Atheroscler. Thromb. 13:21. 5. March, C.J. et al. (1985) Nature 315:641. 6. Auron, P.E. et al. (1984) Proc. Natl. Acad. Sci. 81:7907. 7. Martinon, F. and J. Tschopp (2007) Cell Death Differ. 14:10

Other Notes

Small volumes of IL-1 beta active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-1 beta purchase

MBS692005 is an active protein targeting IL-1 beta. Also known as Human IL-1 beta. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-1 beta. It may not necessarily be applicable to this product.

NCBI GI #
10835145
NCBI GeneID
3553
NCBI Accession #
NP_000567
UniProt Primary Accession #
P01584
UniProt Secondary Accession #
Q53X59; Q53XX2; Q7M4S7; Q7RU01; Q96HE5; Q9UCT6
UniProt Related Accession #
P01584
GenBank Nucleotide #
NM000576
NCBI Official Full Name
interleukin-1 beta proprotein
NCBI Official Synonym Full Names
interleukin 1, beta
NCBI Official Symbol
IL1B
NCBI Official Synonym Symbols
IL-1; IL1F2; IL1-BETA
UniProt Protein Name
Interleukin-1 beta
UniProt Synonym Protein Names
Catabolin
Protein Family
Invertase
UniProt Gene Name
IL1B
UniProt Synonym Gene Names
IL1F2; IL-1 beta
UniProt Entry Name
IL1B_HUMAN
NCBI Protein Information
interleukin-1 beta; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta

NCBI Summary for IL-1 beta

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for IL-1 beta

Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Ref.16

Subunit structure: Monomer.

Subcellular location: Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similarities: Belongs to the IL-1 family.
Show more

Research Articles on IL-1 beta

1. Effects of omalizumab on eosinophil cationic peptide, 25-hydroxyvitamin-D, IL-1beta and sCD200 in cases of Samter's syndrome

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL-1 beta active protein

 Reference Product  PubMed Publications
 IL6 active protein  >216 publications with IL-1 beta and IL6
 CASP1 active protein  >37 publications with IL-1 beta and CASP1
 IL1R1 active protein  >34 publications with IL-1 beta and IL1R1
 NFKB1 active protein  >19 publications with IL-1 beta and NFKB1
 NOS2 active protein  >18 publications with IL-1 beta and NOS2
 IL18 active protein  >18 publications with IL-1 beta and IL18
 MYD88 active protein  >15 publications with IL-1 beta and MYD88
 IL1R2 active protein  >10 publications with IL-1 beta and IL1R2
 IL23A active protein  >4 publications with IL-1 beta and IL23A
 IL1RAP active protein  >3 publications with IL-1 beta and IL1RAP

Pathways associated with IL-1 beta active protein

 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cellular Roles Of Anthrax Toxin Pathway antibodies  Cellular Roles Of Anthrax Toxin Pathway Diagram

Diseases associated with IL-1 beta active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >275 publications with IL-1 beta and Inflammation
 Necrosis Antibodies  >183 publications with IL-1 beta and Necrosis
 Skin Diseases Antibodies  >40 publications with IL-1 beta and Skin Diseases
 Stomach Neoplasms Antibodies  >35 publications with IL-1 beta and Stomach Neoplasms
 Arthritis, Rheumatoid Antibodies  >25 publications with IL-1 beta and Arthritis, Rheumatoid
 Adenocarcinoma Antibodies  >22 publications with IL-1 beta and Adenocarcinoma
 Myocardial Ischemia Antibodies  >18 publications with IL-1 beta and Myocardial Ischemia
 Asthma Antibodies  >16 publications with IL-1 beta and Asthma
 Hypersensitivity Antibodies  >13 publications with IL-1 beta and Hypersensitivity
 Fever Antibodies  >12 publications with IL-1 beta and Fever

Organs/Tissues associated with IL-1 beta active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >235 publications with IL-1 beta and Blood
 Lung Antibodies  >59 publications with IL-1 beta and Lung
 Uterus Antibodies  >48 publications with IL-1 beta and Uterus
 Stomach Antibodies  >41 publications with IL-1 beta and Stomach
 Vascular Antibodies  >39 publications with IL-1 beta and Vascular
 Brain Antibodies  >34 publications with IL-1 beta and Brain
 Liver Antibodies  >28 publications with IL-1 beta and Liver
 Skin Antibodies  >27 publications with IL-1 beta and Skin
 Mouth Antibodies  >19 publications with IL-1 beta and Mouth
 Muscle Antibodies  >19 publications with IL-1 beta and Muscle
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000