Mouse MCP-5 (CCL12) Active Protein – Cat# MBS691920

MCP-5 (CCL12) Mouse Active Protein

Name: MCP-5 (CCL12) Active Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS691920
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691920

MCP-5 or CCL12 is a cloned mouse CC chemokine most closely related to human MCP1 (66% amino acid sequence identity in the mature protein). Mouse MCP-5 encodes a 104 amino acid residue precursor protein with a 22 aa residue predicted hydrophobic signal… More details

$305 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MCP-5 (CCL12), Active Protein

Full Product Name

Mouse MCP-5 (CCL12)

Product Gene Name

MCP-5 (CCL12) active protein

Product Synonym Names

Recombinant Murine MCP-5

Sequence

GPDAVSTPVT CCYNVVKQKI HVRKLKSYRR ITSSQCPREA VIFRTI LDKE ICADPKEKWV KNSINHLDKT SQTFILEPSC LG

Host

E Coli

Species Reactivity

Mouse

Form/Format

Lyophilized

Purity/Purification

> 99% (SDS-PAGE; HPLC)

Molecular Weight

9.2 kDa

Chromosome Location

Chromosome: 14; NC_000080.6 (55941451..55944661, complement). Location: 14 C3; 14 28.19 cM

3D Structure

ModBase 3D Structure for P21844

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng/ug of MCP-5

Biological Activity

Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-50.0 ng/ml.

Product Categories/Family for MCP-5 (CCL12) active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of MCP-5 (CCL12) active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCP-5 (CCL12) purchase

MBS691920 is an active protein targeting MCP-5 (CCL12). Also known as Mouse MCP-5 (CCL12). Reactive in Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MCP-5 (CCL12). It may not necessarily be applicable to this product.

NCBI GI #

6857812

NCBI GeneID

17228

NCBI Accession #

NP_034910.1

UniProt Primary Accession #

P21844

UniProt Secondary Accession #

Q9R1F0

UniProt Related Accession #

P21844

GenBank Nucleotide #

NM_010780.2

NCBI Official Full Name

chymase

NCBI Official Synonym Full Names

chymase 1, mast cell

NCBI Official Symbol

Cma1

NCBI Official Synonym Symbols

Mcp5; Mcp-5; Mcpt5; MMCP-5

UniProt Protein Name

Chymase

UniProt Synonym Protein Names

Alpha-chymase; Mast cell chymase 1; Mast cell protease 5; mMCP-5; Mast cell protease I

UniProt Gene Name

Cma1

UniProt Synonym Gene Names

Mcpt5; mMCP-5

UniProt Entry Name

CMA1_MOUSE

NCBI Protein Information

chymase; alpha-chymase; mast cell chymase 1; mast cell protease 5; mast cell protease I

UniProt Comments for MCP-5 (CCL12)

Function: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.

Catalytic activity: Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.

Subcellular location: Secreted. Cytoplasmic granule. Note: Secretory granules. Ref.6

Tissue specificity: Mast cells.

Sequence similarities: Belongs to the peptidase S1 family. Granzyme subfamily.Contains 1 peptidase S1 domain.

Sequence caution: The sequence CAA48705.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on MCP-5 (CCL12)

1. mast cell/chymase-mediated intestinal epithelial barrier function is mediated by proteinase-activated receptor 2/MMP-2-dependent

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MCP-5 (CCL12) active protein

Products by Pathway	Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies	Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Peptide Hormone Metabolism Pathway antibodies	Peptide Hormone Metabolism Pathway Diagram
Renin-angiotensin System Pathway antibodies	Renin-angiotensin System Pathway Diagram
Renin-angiotensin System Pathway antibodies	Renin-angiotensin System Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By SCF-KIT Pathway antibodies	Signaling By SCF-KIT Pathway Diagram

Diseases associated with MCP-5 (CCL12) active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>9 publications with MCP-5 (CCL12) and Inflammation
Cardiovascular Diseases Antibodies	>9 publications with MCP-5 (CCL12) and Cardiovascular Diseases
Fibrosis Antibodies	>5 publications with MCP-5 (CCL12) and Fibrosis
Neoplasms Antibodies	>5 publications with MCP-5 (CCL12) and Neoplasms
Hypertension Antibodies	>5 publications with MCP-5 (CCL12) and Hypertension
Hypertrophy Antibodies	>3 publications with MCP-5 (CCL12) and Hypertrophy
Necrosis Antibodies	>3 publications with MCP-5 (CCL12) and Necrosis
Pulmonary Fibrosis Antibodies	>2 publications with MCP-5 (CCL12) and Pulmonary Fibrosis
Uterine Cervical Neoplasms Antibodies	>1 publications with MCP-5 (CCL12) and Uterine Cervical Neoplasms
Lung Injury Antibodies	>1 publications with MCP-5 (CCL12) and Lung Injury

Organs/Tissues associated with MCP-5 (CCL12) active protein

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>10 publications with MCP-5 (CCL12) and Skin
Heart Antibodies	>8 publications with MCP-5 (CCL12) and Heart
Bone Marrow Antibodies	>1 publications with MCP-5 (CCL12) and Bone Marrow
Embryonic Tissue Antibodies	>1 publications with MCP-5 (CCL12) and Embryonic Tissue