Mouse TIE-1 Recombinant Protein – Cat# MBS691933

TIE-1, Soluble (TIE-1) Mouse Recombinant Protein

Name: TIE-1 Recombinant Protein; TIE-1, Soluble; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS691933
Price: 355 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691933

Recombinant mouse soluble TIE-1 was fused with a 6x His-tag at the C-terminus. The soluble receptor protein consists of the full extracellular domain (Ser22-Ala748). Mouse sTIE-1 monomer has a calculated molecular mass of approximately 79,8 kDa. As a result… More details

$355 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TIE-1, soluble, Recombinant Protein

Full Product Name

Mouse TIE-1, soluble

Product Gene Name

TIE-1 recombinant protein

Product Synonym Names

Recombinant Mouse soluble TIE-1-His Receptor; Tyrosine-protein kinase Tie-1

Sequence

SVDLTLLANL RITDPQRFFL TCVSGEAGAG RSSDPPLLLE KDDRIVRTFP PGQPLYLARN GSHQVTLRGF SKPSDLVGVF SCVGGAGARR TRVLYVHNSP GAHLFPDKVT HTVNKGDTAV LSAHVHKEKQ TDVIWKNNGS YFNTLDWQEA DDGRFQLQLQ NVQPPSSGIY SATYLEASPL GSAFFRLIVR GCGAGRWGPG CVKDCPGCLH GGVCHDHDGE CVCPPGFTGT RCEQACREGR FGQSCQEQCP GTAGCRGLTF CLPDPYGCSC GSGWRGSQCQ EACAPDHFGA DCRLQCQCQN GGTCDRFSGC VCPSGWHGVH CEKSDRIPQI LSMATEVEFN IGTMPRINCA AAGNPFPVRG SMKLRKPDGT MLLSTKVIVE PDRTTAEFEV PSLTLGDSGF WECRVSTSGG QDSRRFKVNV KVPPVPLTAP RLLAKQSRQL VVSPLVSFSG DGPISSVRLH YRPQDSTIAW SAIVVDPSEN VTLMNLKPKT GYNVRVQLSR PGEGGEGGWG PSALMTTDCP EPLLQPWLES WHVEGPDRLR VSWSLPSVPL SGDGFLLRLW DGARGQERRE NISFPQARTA LLTGLTPGTH YQLDVRLYHC TLLGPASPPA HVHLPPSGPP APRHLHAQAL SDSEIQLMWQ HPEAPSGPIS KYIVEIQVAG GSGDPQWMDV DRPEETSIIV RGLNASTRYL FRVRASVQGL GDWSNTVEEA TLGNGLQSED PVRESRATRH HHHHH

Host

Insect Cells

Species Reactivity

Mouse

Form/Format

Lyophilized

Purity/Purification

> 95% by SDS-PAGE & silver stain

Preparation and Storage

Lyophilized samples are stable for greater than six months at -20 degree C to -70 degree C. Reconstituted sTIE-1-His should be stored in working aliquots at -20 degree C.

Molecular Weight

95 kDa

Chromosome Location

Chromosome: 4; NC_000070.6 (118471191..118489849, complement). Location: 4 D2.1; 4 54.67 cM

3D Structure

ModBase 3D Structure for Q06806

N Terminal Sequence

SVDLTLLANL

Buffer

PBS

Product Categories/Family for TIE-1 recombinant protein

Soluble receptors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Product References and Citations for TIE-1 recombinant protein

1. Partanen J and DJ Dumont (1999) Curr Top Microbiol Immunol 237:159. 2. Takakura N et al, (1998) Immunity 9:677. 3. Procopio W et al, (1999) J Biol Chem 274:30196. 4. Sato et al., PNAS 90:9355, 1993 5. Gale et al., Gen Dev 13:1055, 1999

Other Notes

Small volumes of TIE-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TIE-1 purchase

MBS691933 is a recombinant protein targeting TIE-1. Also known as Mouse TIE-1, soluble. Reactive in Mouse. Host: Insect Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TIE-1. It may not necessarily be applicable to this product.

NCBI GI #

144446133

NCBI GeneID

21846

NCBI Accession #

NP_03517.2

UniProt Primary Accession #

Q06806

UniProt Secondary Accession #

Q811F4; Q8BGI2

UniProt Related Accession #

Q06806

GenBank Nucleotide #

NM_011587.2

NCBI Official Full Name

tyrosine-protein kinase receptor Tie-1

NCBI Official Synonym Full Names

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

NCBI Official Symbol

Tie1

NCBI Official Synonym Symbols

TIE; tie-1; D430008P04Rik

UniProt Protein Name

Tyrosine-protein kinase receptor Tie-1

UniProt Gene Name

Tie1

UniProt Synonym Gene Names

Tie; Tie-1

UniProt Entry Name

TIE1_MOUSE

NCBI Protein Information

tyrosine-protein kinase receptor Tie-1; tyrosine kinase receptor 1

UniProt Comments for TIE-1

Function: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis

By similarity.

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure: Heterodimer with TEK/TIE2

By similarity.

Subcellular location: Cell membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Specifically expressed in developing vascular endothelial cells. Abundantly expressed in lung and heart, moderately in brain, liver and kidney, and weakly in thymus, spleen and testis. Ref.3

Post-translational modification: Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2

By similarity.

Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.Contains 3 EGF-like domains.Contains 3 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.

Research Articles on TIE-1

1. Shear stress conditions that modulate atherogenic events also regulate Tie1 expression. Therefore, Tie1 may play a novel proinflammatory role in atherosclerosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TIE-1 recombinant protein

Products by Pathway	Pathway Diagram
XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies	XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with TIE-1 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>28 publications with TIE-1 and Neoplasms
Inflammation Antibodies	>7 publications with TIE-1 and Inflammation
Hemorrhage Antibodies	>7 publications with TIE-1 and Hemorrhage
Edema Antibodies	>6 publications with TIE-1 and Edema
Necrosis Antibodies	>6 publications with TIE-1 and Necrosis
Liver Neoplasms Antibodies	>4 publications with TIE-1 and Liver Neoplasms
Brain Diseases Antibodies	>4 publications with TIE-1 and Brain Diseases
Respiratory Tract Diseases Antibodies	>3 publications with TIE-1 and Respiratory Tract Diseases
Bone Diseases Antibodies	>2 publications with TIE-1 and Bone Diseases
Kidney Diseases Antibodies	>2 publications with TIE-1 and Kidney Diseases

Organs/Tissues associated with TIE-1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>38 publications with TIE-1 and Embryonic Tissue
Heart Antibodies	>21 publications with TIE-1 and Heart
Bone Antibodies	>11 publications with TIE-1 and Bone
Liver Antibodies	>10 publications with TIE-1 and Liver
Kidney Antibodies	>9 publications with TIE-1 and Kidney
Lung Antibodies	>9 publications with TIE-1 and Lung
Skin Antibodies	>8 publications with TIE-1 and Skin
Brain Antibodies	>7 publications with TIE-1 and Brain
Bone Marrow Antibodies	>7 publications with TIE-1 and Bone Marrow
Joint Antibodies	>6 publications with TIE-1 and Joint