Human LEP Active Protein – Cat# MBS691942

Leptin (LEP) Human Active Protein

Name: LEP Active Protein; Leptin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS691942
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691942

Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body… More details

$305 / 0.2 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Leptin, Active Protein

Full Product Name

Human Leptin

Product Gene Name

LEP active protein

Product Synonym Names

Recombinant Human Leptin

Sequence

MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGL HPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV L AFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDM LWQ LDLSPGC

Host

E Coli

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

95 % (SDS-PAGE, HPLC)

Molecular Weight

16.0 kDa

Chromosome Location

Chromosome: 7; NC_000007.14 (128241189..128257629). Location: 7q31.3

OMIM

164160

3D Structure

ModBase 3D Structure for P41159

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng per ug of Leptin

Biological Activity

Human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 ug Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.

Product Categories/Family for LEP active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of LEP active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LEP purchase

MBS691942 is an active protein targeting LEP. Also known as Human Leptin. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LEP. It may not necessarily be applicable to this product.

NCBI GI #

4557715

NCBI GeneID

3952

NCBI Accession #

NP_000221.1

UniProt Primary Accession #

P41159

UniProt Secondary Accession #

O15158; Q56A88

UniProt Related Accession #

P41159

GenBank Nucleotide #

NM_000230.2

NCBI Official Full Name

leptin

NCBI Official Synonym Full Names

leptin

NCBI Official Symbol

LEP

NCBI Official Synonym Symbols

OB; OBS; LEPD

UniProt Protein Name

Leptin

UniProt Synonym Protein Names

Obese protein; Obesity factor

Protein Family

Ethylene-responsive transcription factor

UniProt Gene Name

LEP

UniProt Synonym Gene Names

OB; OBS

UniProt Entry Name

LEP_HUMAN

NCBI Protein Information

leptin; obese protein; obesity factor; obese, mouse, homolog of; leptin (murine obesity homolog); leptin (obesity homolog, mouse)

NCBI Summary for LEP

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]

UniProt Comments for LEP

Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.

Subunit structure: Interacts with SIGLEC6. Ref.11

Subcellular location: Secreted.

Involvement in disease: Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.16

Sequence similarities: Belongs to the leptin family.

Research Articles on LEP

1. Increased leptin is located in cerebrospinal fluid (CSF) and hippocampal tissue in Alzheimer disease, indicating its physiological up-regulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LEP active protein

Reference Product	PubMed Publications
LEPR active protein	>156 publications with LEP and LEPR
STAT3 active protein	>14 publications with LEP and STAT3
INS active protein	>11 publications with LEP and INS
GHRL active protein	>11 publications with LEP and GHRL
CRP active protein	>6 publications with LEP and CRP
JAK2 active protein	>5 publications with LEP and JAK2
PTPN1 active protein	>2 publications with LEP and PTPN1
SOCS3 active protein	>1 publications with LEP and SOCS3

Pathways associated with LEP active protein

Products by Pathway	Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
HIF-1-alpha Transcription Factor Network Pathway antibodies	HIF-1-alpha Transcription Factor Network Pathway Diagram
Incretin Synthesis, Secretion, And Inactivation Pathway antibodies	Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with LEP active protein

Disease Name	Pubmed Publications
Obesity Antibodies	>317 publications with LEP and Obesity
Pain Antibodies	>160 publications with LEP and Pain
Insulin Resistance Antibodies	>105 publications with LEP and Insulin Resistance
Hyperinsulinism Antibodies	>67 publications with LEP and Hyperinsulinism
Weight Gain Antibodies	>54 publications with LEP and Weight Gain
Weight Loss Antibodies	>50 publications with LEP and Weight Loss
Cardiovascular Diseases Antibodies	>49 publications with LEP and Cardiovascular Diseases
Fatty Liver Antibodies	>39 publications with LEP and Fatty Liver
Inflammation Antibodies	>36 publications with LEP and Inflammation
Liver Diseases Antibodies	>32 publications with LEP and Liver Diseases

Organs/Tissues associated with LEP active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>337 publications with LEP and Blood
Adipose Tissue Antibodies	>156 publications with LEP and Adipose Tissue
Muscle Antibodies	>113 publications with LEP and Muscle
Connective Tissue Antibodies	>112 publications with LEP and Connective Tissue
Intestine Antibodies	>20 publications with LEP and Intestine
Placenta Antibodies	>16 publications with LEP and Placenta
Mouth Antibodies	>9 publications with LEP and Mouth
Mammary Gland Antibodies	>3 publications with LEP and Mammary Gland
Thymus Antibodies	>2 publications with LEP and Thymus