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MDC (69 Aa) (MDC) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691988

MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive… More details

$305 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MDC (69 aa), Active Protein
Full Product Name
Human MDC (69 aa)
Product Gene Name
Product Synonym Names
Recombinant Human MDC (69 aa)
Sequence
GPYGANMEDS VCCRDYVRYR LPLRVVKHFY WTSDSCPRPG VVLLTF RDKE ICADPRVPWV KMILNKLSQ
Host
E Coli
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
99 % (SDS-PAGE, HPLC)
Molecular Weight
8.1 kDa
Chromosome Location
Chromosome: 17; NC_000017.11 (44759037..44781846). Location: 17q21.3
OMIM
155120
3D Structure
ModBase 3D Structure for O75078
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng per ug of MDC
Biological Activity
Determined by its ability to chemoattract human T cells using a concentration range of 10.0-100.0 ng/ml.

Product Categories/Family for MDC active protein

ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of MDC active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MDC purchase

MBS691988 is an active protein targeting MDC. Also known as Human MDC (69 aa). Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MDC. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
disintegrin and metalloproteinase domain-containing protein 11 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 11
NCBI Official Symbol
ADAM11
NCBI Official Synonym Symbols
MDC
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 11
UniProt Synonym Protein Names
Metalloproteinase-like, disintegrin-like, and cysteine-rich protein
UniProt Gene Name
ADAM11
UniProt Synonym Gene Names
MDC; ADAM 11; MDC
UniProt Entry Name
ADA11_HUMAN
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 11; ADAM 11

NCBI Summary for MDC

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq, Jul 2008]
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UniProt Comments for MDC

Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

Subunit structure: Can bind to LGI1 and LGI4

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Expressed predominantly in brain. Slightly detected or not at all in other tissues.

Domain: A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.

Post-translational modification: The precursor is cleaved by a furin endopeptidase

By similarity.

Sequence similarities: Contains 1 disintegrin domain.Contains 1 EGF-like domain.Contains 1 peptidase M12B domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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