• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

IL-6 Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS692009

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates… More details

$295 / 0.005 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-6, Active Protein
Full Product Name
Mouse IL-6
Product Gene Name
IL-6 active protein
Product Synonym Names
Recombinant Murine IL-6
Sequence
MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKEL CNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI S SGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDL HKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TL RSTRQT
Host
E Coli
Species Reactivity
Mouse
Form/Format
Lyophilized
Purity/Purification
> 98% by SDS-PAGE & Coomassie Stain
Preparation and Storage
The lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 12 months at -20°C to -80°C.
Molecular Weight
21.7 kDa
Chromosome Location
Chromosome: 5; NC_000071.6 (30013161..30019968). Location: 5 B1; 5 15.7 cM
3D Structure
ModBase 3D Structure for P08505
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng /ug of protein (<1EU/ug)
Length (aa)
188
Result by N-terminal sequencing
M F P T S
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in 50 mM acetic acid to a concentration of 0.1-1.0 mg/m. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer (e.g. PBS) containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Biological Activity
The ED50 as determined by the dose-dependent stimulation of murine hybridoma B9 cells is in the range of 5-20 pg/ml.

Product Categories/Family for IL-6 active protein

Cytokines & Growth Factors
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

SDS-PAGE of IL-6 active protein

SDS-PAGE analysis of recombinant mouse IL-6. Sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with Coomassie blue.
Mouse IL-6 Active Protein – Cat# MBS692009

Testing Data (TD) of IL-6 active protein

Proliferation assay with the mouse hybridoma cell line B9. The cells were stimulated with increasing amounts of recombinant mouse IL-6.
Mouse IL-6 Active Protein, Testing Data (TD) – Cat# MBS692009

Other Notes

Small volumes of IL-6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-6 purchase

MBS692009 is an active protein targeting IL-6. Also known as Mouse IL-6. Reactive in Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-6. It may not necessarily be applicable to this product.

NCBI GI #
13624311
NCBI GeneID
16193
NCBI Accession #
NP_112445.1
UniProt Primary Accession #
P08505
UniProt Secondary Accession #
Q3UCQ0; Q8BN26
UniProt Related Accession #
P08505
GenBank Nucleotide #
NM_031168.1
NCBI Official Full Name
interleukin-6
NCBI Official Synonym Full Names
interleukin 6
NCBI Official Symbol
Il6
NCBI Official Synonym Symbols
Il-6
UniProt Protein Name
Interleukin-6
UniProt Synonym Protein Names
B-cell hybridoma growth factor; Interleukin HP-1
UniProt Gene Name
Il6
UniProt Synonym Gene Names
Il-6; IL-6
UniProt Entry Name
IL6_MOUSE
NCBI Protein Information
interleukin-6; interleukin HP-1; B-cell hybridoma growth factor

UniProt Comments for IL-6

Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance

By similarity.

Subcellular location: Secreted.

Sequence similarities: Belongs to the IL-6 superfamily.
Show more

Research Articles on IL-6

1. IL-6 induces liver fatty acid binding protein kinetics in hepatocytes and is partially dependent on PPARalpha.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IL-6 active protein

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram

Diseases associated with IL-6 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1921 publications with IL-6 and Inflammation
 Necrosis Antibodies  >1435 publications with IL-6 and Necrosis
 Autoimmune Diseases Antibodies  >385 publications with IL-6 and Autoimmune Diseases
 Arthritis, Rheumatoid Antibodies  >230 publications with IL-6 and Arthritis, Rheumatoid
 Myocardial Ischemia Antibodies  >201 publications with IL-6 and Myocardial Ischemia
 Atherosclerosis Antibodies  >201 publications with IL-6 and Atherosclerosis
 Ischemia Antibodies  >106 publications with IL-6 and Ischemia
 Myocardial Infarction Antibodies  >90 publications with IL-6 and Myocardial Infarction
 Hypersensitivity Antibodies  >90 publications with IL-6 and Hypersensitivity
 Diabetes Mellitus, Type 2 Antibodies  >85 publications with IL-6 and Diabetes Mellitus, Type 2

Organs/Tissues associated with IL-6 active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >332 publications with IL-6 and Lung
 Bone Marrow Antibodies  >173 publications with IL-6 and Bone Marrow
 Eye Antibodies  >101 publications with IL-6 and Eye
 Spleen Antibodies  >78 publications with IL-6 and Spleen
 Embryonic Tissue Antibodies  >68 publications with IL-6 and Embryonic Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000