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Exodus-2 (CCL21) Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS692024

Exodus-2 is a CC chemokine that can signal through the CCR7 receptor. It is expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. Exodus-2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Exodus-2 contains six… More details

$305 / 0.005 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Exodus-2 (CCL21), Active Protein
Full Product Name
Mouse Exodus-2 (CCL21)
Product Gene Name
CCL21 active protein
Product Synonym Names
Recombinant Murine Exodus-2
Sequence
SDGGGQDCCL KYSQKKIPYS IVRGYRKQEP SLGCPIPAIL FLPRKH SKPE LCANPEEGWV QNLMRRLDQP PAPGKQSPGC RKNRGTSKSG K KGKGSKGCK RTEQTQPSRG
Host
E Coli
Species Reactivity
Mouse
Form/Format
Lyophilized
Purity/Purification
> 98% (SDS-PAGE; HPLC)
Molecular Weight
12.0 kDa
Chromosome Location
4 A5; 4
3D Structure
ModBase 3D Structure for P84444
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng/ug of Exodus-2
Biological Activity
Determined by its ability to chemoattract total murine T cell population using a concentration range of 10.0-100.0 ng/ml.

Product Categories/Family for CCL21 active protein

Cytokines & Growth Factors
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of CCL21 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL21 purchase

MBS692024 is an active protein targeting CCL21. Also known as Mouse Exodus-2 (CCL21). Reactive in Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL21. It may not necessarily be applicable to this product.

NCBI GI #
302488378
NCBI GeneID
100504362
NCBI Accession #
NP_001180596.1
UniProt Primary Accession #
P84444
UniProt Secondary Accession #
O09002; O09006; Q3U1J2; Q91V84
GenBank Nucleotide #
NM_001193667.1
NCBI Official Full Name
predicted gene 1987
NCBI Official Synonym Full Names
predicted gene 1987
NCBI Official Symbol
Gm1987
NCBI Official Synonym Symbols
100038965
UniProt Protein Name
C-C motif chemokine 21a
UniProt Synonym Protein Names
6Ckine; Beta-chemokine exodus-2; Small-inducible cytokine A21a; Thymus-derived chemotactic agent 4
Protein Family
C-C motif chemokine
UniProt Gene Name
Ccl21a
UniProt Synonym Gene Names
Scya21; Scya21a; TCA4
UniProt Entry Name
CC21A_MOUSE
NCBI Protein Information
predicted gene 1987

UniProt Comments for CCL21

Function: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.

Subunit structure: Binds to CCR7 and to CXCR3.

Subcellular location: Secreted.

Tissue specificity: Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.

Involvement in disease: Mice carrying an autosomal recessive mutation designated paucity of lymph node T-cells (plt) show dramatically reduced numbers of T-cells in lymph nodes, Peyer patches, and the white pulp of the spleen. Plt seems to correspond to Scya21b.

Miscellaneous: Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have 'Leu-65' (6Ckine-Leu) while Ccl21a has Ser-65 (6Ckine-Ser).

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CCL21 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
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