Human MIP-1 beta (CCL4) Active Protein – Cat# MBS692135

MIP-1 beta (CCL4) Human Active Protein

Name: MIP-1 beta (CCL4) Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS692135
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS692135

Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups… More details

$305 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MIP-1 beta (CCL4), Active Protein

Full Product Name

Human MIP-1 beta (CCL4)

Product Gene Name

MIP-1 beta (CCL4) active protein

Product Synonym Names

Recombinant Human MIP-1beta

Sequence

APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKR GKQV CADPSESWVQ EYVYDLELN

Host

E Coli

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

> 99 % (SDS-PAGE, HPLC)

Molecular Weight

7.6 kDa

Chromosome Location

Chromosome: 17; NC_000017.11 (36211066..36212873). Location: 17q12

OMIM

182284

3D Structure

ModBase 3D Structure for P13236

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng per ug of MIP-1beta

Biological Activity

Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml.

Product Categories/Family for MIP-1 beta (CCL4) active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of MIP-1 beta (CCL4) active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIP-1 beta (CCL4) purchase

MBS692135 is an active protein targeting MIP-1 beta (CCL4). Also known as Human MIP-1 beta (CCL4). Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP-1 beta (CCL4). It may not necessarily be applicable to this product.

NCBI GI #

47824887

NCBI GeneID

9560

NCBI Accession #

NP_001001435.1

UniProt Primary Accession #

P13236

UniProt Secondary Accession #

P22617; Q13704; Q3SXL8; Q6FGI8

UniProt Related Accession #

Q8NHW4

GenBank Nucleotide #

NM_001001435.2

NCBI Official Full Name

C-C motif chemokine 4-like

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 4-like 1

NCBI Official Symbol

CCL4L1

NCBI Official Synonym Symbols

LAG1; CCL4L; LAG-1; SCYA4L; AT744.2

UniProt Protein Name

C-C motif chemokine 4

UniProt Synonym Protein Names

G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta(1-69); Macrophage inflammatory protein 1-beta; MIP-1-beta; PAT 744; Protein H400; SIS-gamma; Small-inducible cytokine A4; T-cell activation protein 2

UniProt Gene Name

CCL4

UniProt Synonym Gene Names

LAG1; MIP1B; SCYA4; LAG-1; MIP-1-beta; ACT-2

UniProt Entry Name

CCL4_HUMAN

NCBI Protein Information

C-C motif chemokine 4-like; MIP-1-beta; macrophage inflammatory protein-1b2; lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; monocyte adherence-induced protein 5-alpha

NCBI Summary for MIP-1 beta (CCL4)

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein is similar to CCL4 which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals; most individuals have 1-5 copies in the diploid genome, although rare individuals do not contain this gene at all. The human genome reference assembly contains two copies of this gene. This record represents the more centromeric gene. [provided by RefSeq, Jul 2008]

UniProt Comments for MIP-1 beta (CCL4)

Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B Ref.13 Ref.14 Ref.15

Subunit structure: Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). Ref.15

Subcellular location: Secreted.

Induction: By mitogens.

Post-translational modification: N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

Caution: Was originally (Ref.12) thought to be a ligand for CCR8.

Research Articles on MIP-1 beta (CCL4)

1. CCL4L1 allele frequency is higher in severe psoriasis, whereas CCL4L2 is more frequent in patients with a milder disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MIP-1 beta (CCL4) active protein

Reference Product	PubMed Publications
CCL3 active protein	>5 publications with MIP-1 beta (CCL4) and CCL3
CCR5 active protein	>3 publications with MIP-1 beta (CCL4) and CCR5
CCR3 active protein	>1 publications with MIP-1 beta (CCL4) and CCR3
CCR1 active protein	>1 publications with MIP-1 beta (CCL4) and CCR1

Pathways associated with MIP-1 beta (CCL4) active protein

Products by Pathway	Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
IL12-mediated Signaling Events Pathway antibodies	IL12-mediated Signaling Events Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram

Diseases associated with MIP-1 beta (CCL4) active protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>4 publications with MIP-1 beta (CCL4) and Immune System Diseases
Disease Susceptibility Antibodies	>3 publications with MIP-1 beta (CCL4) and Disease Susceptibility
Diabetes Mellitus Antibodies	>1 publications with MIP-1 beta (CCL4) and Diabetes Mellitus

Organs/Tissues associated with MIP-1 beta (CCL4) active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>5 publications with MIP-1 beta (CCL4) and Blood
Kidney Antibodies	>1 publications with MIP-1 beta (CCL4) and Kidney
Lung Antibodies	>1 publications with MIP-1 beta (CCL4) and Lung