Human DLL-1 Active Protein – Cat# MBS692170

DLL-1, Soluble (DLL-1) Human Active Protein

Name: DLL-1 Active Protein; DLL-1, Soluble; Human; MyBioSource
Brand: MyBioSource
SKU: MBS692170
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS692170

Human sDLL-1 comprises the extracellular signaling domain of DLL1, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and to a lesser… More details

$305 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DLL-1, soluble, Active Protein

Full Product Name

Human DLL-1, soluble

Product Gene Name

DLL-1 active protein

Product Synonym Names

Recombinant Human sDLL-1

Sequence

SGVFELKLQE FVNKKGLLGN RNCCRGGAGP PPCACRTFFR VCLKHY QASV SPEPPCTYGS AVTPVLGVDS FSLPDGGGAD SAFSNPIRFP F GFTWPGTFS LIIEALHTDS PDDLATENPE RLISRLATQR HLTVGEE WSQ DLHSSGRTDL KYSYRFVCDE HYYGEGCSVF CRPRDDAFGH FT CGERGEKV CNPGWKGPYC TEPICLPGCD EQHGFCDKPG ECKCRVGW QG RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTH HKPCKNG ATCTNTGQGS YTCSCRPGYT GATCELGIDE CDPSPCKNG G SCTDLENSYS CTCPPGFYGK ICELSAMTCA DGPCFNGGRC SDSP DGGYSC RCPVGYSGFN CEKKIDYCSS SPCSNGAKCV DLGDAYLCRC QAGFSGRHCD DNVDDCASSP CANGGTCRDG VNDFSCTCPP GYTGR NCSAP VSRCEHAPCH NGATCHERGH RYVCECARGY GGPNCQFLLP ELPPGPAVVD LTEKLEGQGG PF

Host

HEK 293 Cells

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

> 95%, by SDS-PAGE and HPLC analysis

Molecular Weight

57-60 kDa

Chromosome Location

Chromosome: 6; NC_000006.12 (170282200..170290727, complement). Location: 6q27

OMIM

606582

3D Structure

ModBase 3D Structure for O00548

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng per ug of sDLL-1

Biological Activity

Determined by the dose dependent growth suppression of the human acute monocytic leukemia cell line, THP-1. sDLL-1 inhibits the proliferation in THP-1 cells using a concentration of 3.0-5.0 ug/ml.

Product Categories/Family for DLL-1 active protein

Soluble receptors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of DLL-1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DLL-1 purchase

MBS692170 is an active protein targeting DLL-1. Also known as Human DLL-1, soluble. Reactive in Human. Host: HEK 293 Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for DLL-1. It may not necessarily be applicable to this product.

NCBI GI #

110735443

NCBI GeneID

28514

NCBI Accession #

NP_005609.3

UniProt Primary Accession #

O00548

UniProt Secondary Accession #

Q9NU41; Q9UJV2; B2RAK7

UniProt Related Accession #

O00548

GenBank Nucleotide #

NM_005618.3

NCBI Official Full Name

delta-like protein 1

NCBI Official Synonym Full Names

delta-like 1 (Drosophila)

NCBI Official Symbol

DLL1

NCBI Official Synonym Symbols

DL1; Delta; DELTA1

UniProt Protein Name

Delta-like protein 1

UniProt Synonym Protein Names

Drosophila Delta homolog 1

UniProt Gene Name

DLL1

UniProt Synonym Gene Names

Delta1; H-Delta-1

UniProt Entry Name

DLL1_HUMAN

NCBI Protein Information

delta-like protein 1; H-Delta-1; drosophila Delta homolog 1

NCBI Summary for DLL-1

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]

UniProt Comments for DLL-1

Function: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Ref.8

Subunit structure: Interacts with Notch receptors.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

Post-translational modification: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation

By similarity.

Sequence similarities: Contains 1 DSL domain.Contains 8 EGF-like domains.

Research Articles on DLL-1

1. Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DLL-1 active protein

Reference Product	PubMed Publications
NOTCH1 active protein	>91 publications with DLL-1 and NOTCH1
NOTCH2 active protein	>32 publications with DLL-1 and NOTCH2
JAG1 active protein	>28 publications with DLL-1 and JAG1
HES5 active protein	>24 publications with DLL-1 and HES5
JAG2 active protein	>15 publications with DLL-1 and JAG2
NOTCH3 active protein	>14 publications with DLL-1 and NOTCH3
MIB1 active protein	>5 publications with DLL-1 and MIB1
ADAM10 active protein	>2 publications with DLL-1 and ADAM10

Pathways associated with DLL-1 active protein

Products by Pathway	Pathway Diagram
Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies	Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies	Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
Delta-Notch Signaling Pathway antibodies	Delta-Notch Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies	FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies	NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
Neural Crest Differentiation Pathway antibodies	Neural Crest Differentiation Pathway Diagram

Diseases associated with DLL-1 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>31 publications with DLL-1 and Neoplasms
Congenital Abnormalities Antibodies	>10 publications with DLL-1 and Congenital Abnormalities
Immune System Diseases Antibodies	>10 publications with DLL-1 and Immune System Diseases
Disease Models, Animal Antibodies	>9 publications with DLL-1 and Disease Models, Animal
Carcinoma Antibodies	>8 publications with DLL-1 and Carcinoma
Nervous System Diseases Antibodies	>7 publications with DLL-1 and Nervous System Diseases
Inflammation Antibodies	>6 publications with DLL-1 and Inflammation
Intestinal Neoplasms Antibodies	>6 publications with DLL-1 and Intestinal Neoplasms
Abnormalities, Multiple Antibodies	>5 publications with DLL-1 and Abnormalities, Multiple
Lung Diseases Antibodies	>4 publications with DLL-1 and Lung Diseases

Organs/Tissues associated with DLL-1 active protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>39 publications with DLL-1 and Embryonic Tissue
Brain Antibodies	>33 publications with DLL-1 and Brain
Lung Antibodies	>14 publications with DLL-1 and Lung
Kidney Antibodies	>7 publications with DLL-1 and Kidney
Intestine Antibodies	>7 publications with DLL-1 and Intestine
Eye Antibodies	>6 publications with DLL-1 and Eye
Skin Antibodies	>6 publications with DLL-1 and Skin
Ear Antibodies	>5 publications with DLL-1 and Ear
Connective Tissue Antibodies	>4 publications with DLL-1 and Connective Tissue
Placenta Antibodies	>2 publications with DLL-1 and Placenta