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TWEAK Receptor, Soluble (TWEAK receptor) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS692184

TWEAK-R belongs to the TNF family of transmembrane proteins and contains a cytoplasmic "ždeath domain", which can activated the cell\'s apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine.… More details

$305 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TWEAK receptor, soluble, Active Protein
Full Product Name
Human TWEAK receptor, soluble
Product Synonym Names
Recombinant Human TWEAK Receptor
Sequence
EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPA PFRL LWP
Host
E Coli
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
> 98% by SDS-PAGE and HPLC analyses
Molecular Weight
5,6 kDa
Chromosome Location
Chromosome: 16; NC_000016.10 (3020312..3022383). Location: 16p13.3
OMIM
605914
3D Structure
ModBase 3D Structure for Q9NP84
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng per ìg of sTWEAK
Biological Activity
Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 ug/ml.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of TWEAK receptor active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TWEAK receptor purchase

MBS692184 is an active protein targeting TWEAK receptor. Also known as Human TWEAK receptor, soluble. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TWEAK receptor. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 12A
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 12A
NCBI Official Symbol
TNFRSF12A
NCBI Official Synonym Symbols
FN14; CD266; TWEAKR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 12A
UniProt Synonym Protein Names
Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor
UniProt Gene Name
TNFRSF12A
UniProt Synonym Gene Names
FN14; FGF-inducible 14; TweakR
UniProt Entry Name
TNR12_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 12A; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14

UniProt Comments for TWEAK receptor

Function: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Ref.5

Subunit structure: Associates with TRAF1 and TRAF2, and probably also with TRAF3.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

Induction: By FGF1 and phorbol ester.

Sequence similarities: Contains 1 TNFR-Cys repeat.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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