TIE-2 Antibody – Rat Monoclonal

TIE2: a receptor tyrosine kinase of the Tie family. Receptor for angiopoietin 1. Expressed almost exclusively in endothelial cells. May constitute the earliest mammalian endothelial cell lineage marker. Appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

Protein type: EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; Tie family

Cellular Component: microvillus; cell surface; basolateral plasma membrane; integral to plasma membrane; extracellular region; integral to membrane; actin filament; intercellular junction; lipid raft; cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; plasma membrane; basal plasma membrane; stress fiber; cell junction

Molecular Function: transferase activity; protein binding; growth factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; receptor activity; kinase activity; ATP binding; protein kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of cell adhesion; protein amino acid autophosphorylation; heart development; cell-matrix adhesion; positive regulation of cytokine secretion during immune response; regulation of cell migration; protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; cell-cell adhesion; positive regulation of focal adhesion formation; hemopoiesis; angiogenesis; vasculogenesis; regulation of endothelial cell proliferation; Tie receptor signaling pathway; response to retinoic acid; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase activity; regulation of angiogenesis; positive regulation of peptidyl-serine phosphorylation; protein oligomerization; patterning of blood vessels; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; negative regulation of angiogenesis; positive regulation of protein import into nucleus; response to estrogen stimulus; endothelial cell proliferation; sprouting angiogenesis; positive regulation of protein amino acid phosphorylation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis