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ROR2 Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS692286

ROR2 is a signaling receptor for Wnt ligands that is known to play important roles in limb development, but having no essential roles known in adult tissues. Recent evidence has implicated ROR2 in mediating both canonical and non-canonical signaling pathways.… More details

$295 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ROR2, Active Protein
Full Product Name
Human ROR2, soluble
Product Gene Name
ROR2 active protein
Product Synonym Names
Neurotrophic tyrosine kinase; receptor-related 2
Sequence
Result by N-terminal sequencing -EVEVL
EVEVLDPNDP LGPLDGQDGP IPTLKGYFLN FLEPVNNITI VQGQTA ILHC KVAGNPPPNV RWLKNDAPVV QEPRRIIIRK TEYGSRLRIQ D LDTTDTGYY QCVATNGMKT ITATGVLFVR LGPTHSPNHN FQDDYHE DGF CQPYRGIACA RFIGNRTIYV DSLQMQGEIE NRITAAFTMI GT STHLSDQC SQFAIPSFCH FVFPLCDARS RTPKPRELCR DECEVLES DL CRQEYTIARS NPLILMRLQL PKCEALPMPE SPDAANCMRI GIP AERLGRY HQCYNGSGMD YRGTASTTKS GHQCQPWALQ HPHSHHLSS T DFPELGGGHA YCRNPGGQME GPWCFTQNKN VRMELCDVPS CSPR DSSKMG HHHHHH
Host
Insect cells
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
> 98% by SDS-PAGE & Coomassie stain
Preparation and Storage
Lyophilized samples are stable for greater than six months at -20 degree C to -70 degree C. Reconstituted sROR2 should be stored in working aliquots at -70 degree C.
Molecular Weight
104,757 Da
OMIM
113000
3D Structure
ModBase 3D Structure for Q01974
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Reconstitution
The lyophilized sROR2 is soluble in water and most aqueous buffers and should be reconstituted in water to a concentration not lower than 100 ug/ml.
Biological Activity
Binds rh Wnt5a in a functional ELISA.

Product Categories/Family for ROR2 active protein

Recombinant Protein; Soluble Receptors; ROR2; soluble
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

SDS-PAGE of ROR2 active protein

SDS-PAGE analysis of recombinant human sROR2 produced in insect cells. Sample was loaded in 15% SDS-polyacrylamide gel under reducing condition and stained with Coomassie blue.
Human ROR2 Active Protein – Cat# MBS692286

Testing Data of ROR2 active protein

Binding of recombinant human Wnt5a to recombinant human sROR2 in a functional ELISA. sROR2 was coated with 2ug/ml (100ug/well) and increasing amounts of Wnt5a was added. Detection was performed using a polyclonal rabbit anti-human Wnt5a and a goat anti-rabbit Biotin conjugated secondary antibody.
Human ROR2 Active Protein, Testing Data – Cat# MBS692286

Other Notes

Small volumes of ROR2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ROR2 purchase

MBS692286 is an active protein targeting ROR2. Also known as Human ROR2, soluble. Reactive in Human. Host: Insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for ROR2. It may not necessarily be applicable to this product.

NCBI GI #
970598266
NCBI GeneID
4920
NCBI Accession #
NP_001305133.1
UniProt Primary Accession #
Q01974
UniProt Secondary Accession #
Q59GF5; Q5SPI5; Q9HAY7; Q9HB61
UniProt Related Accession #
Q01974
GenBank Nucleotide #
NM_001318204.1
NCBI Official Full Name
tyrosine-protein kinase transmembrane receptor ROR2 isoform 2
NCBI Official Synonym Full Names
receptor tyrosine kinase like orphan receptor 2
NCBI Official Symbol
ROR2
NCBI Official Synonym Symbols
BDB; BDB1; NTRKR2
UniProt Protein Name
Tyrosine-protein kinase transmembrane receptor ROR2
UniProt Synonym Protein Names
Neurotrophic tyrosine kinase, receptor-related 2
Protein Family
Tyrosine-protein kinase transmembrane receptor
UniProt Gene Name
ROR2
UniProt Synonym Gene Names
NTRKR2
UniProt Entry Name
ROR2_HUMAN
NCBI Protein Information
tyrosine-protein kinase transmembrane receptor ROR2

UniProt Comments for ROR2

ROR2: a receptor tyrosine kinase of the ROR family. May be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ror family; TK group

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; Wnt-protein binding

Biological Process: multicellular organismal development; negative regulation of cell proliferation; positive regulation of cell migration; signal transduction; Wnt receptor signaling pathway, planar cell polarity pathway

Disease: Brachydactyly, Type B1; Robinow Syndrome, Autosomal Recessive
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ROR2 active protein

 Reference Product  PubMed Publications
 WNT5A active protein  >155 publications with ROR2 and WNT5A
 FZD7 active protein  >14 publications with ROR2 and FZD7
 FZD5 active protein  >14 publications with ROR2 and FZD5
 VANGL2 active protein  >13 publications with ROR2 and VANGL2
 FZD4 active protein  >12 publications with ROR2 and FZD4
 FZD2 active protein  >12 publications with ROR2 and FZD2
 FZD6 active protein  >10 publications with ROR2 and FZD6
 DVL2 active protein  >6 publications with ROR2 and DVL2
 DVL3 active protein  >5 publications with ROR2 and DVL3
 DVL1 active protein  >3 publications with ROR2 and DVL1

Pathways associated with ROR2 active protein

 Products by Pathway  Pathway Diagram
 Beta-catenin Independent WNT Signaling Pathway antibodies  Beta-catenin Independent WNT Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Noncanonical Wnt Signaling Pathway antibodies  Noncanonical Wnt Signaling Pathway Diagram
 PCP/CE Pathway antibodies  PCP/CE Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 WNT5A-dependent Internalization Of FZD2, FZD5 And ROR2 Pathway antibodies  WNT5A-dependent Internalization Of FZD2, FZD5 And ROR2 Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 Wnt Signaling Network Pathway antibodies  Wnt Signaling Network Pathway Diagram

Diseases associated with ROR2 active protein

 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >24 publications with ROR2 and Abnormalities, Multiple
 Inflammation Antibodies  >10 publications with ROR2 and Inflammation
 Neoplasm Metastasis Antibodies  >8 publications with ROR2 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >8 publications with ROR2 and Kidney Diseases
 Embryo Loss Antibodies  >8 publications with ROR2 and Embryo Loss
 Breast Neoplasms Antibodies  >5 publications with ROR2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >5 publications with ROR2 and Cardiovascular Diseases
 Fibrosis Antibodies  >4 publications with ROR2 and Fibrosis
 Necrosis Antibodies  >4 publications with ROR2 and Necrosis
 Lung Diseases Antibodies  >4 publications with ROR2 and Lung Diseases

Organs/Tissues associated with ROR2 active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >15 publications with ROR2 and Lung
 Heart Antibodies  >15 publications with ROR2 and Heart
 Intestine Antibodies  >13 publications with ROR2 and Intestine
 Eye Antibodies  >9 publications with ROR2 and Eye
 Stomach Antibodies  >7 publications with ROR2 and Stomach
 Uterus Antibodies  >5 publications with ROR2 and Uterus
 Testis Antibodies  >3 publications with ROR2 and Testis
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