Podoplanin (PDPN) Antibody – Mouse Monoclonal

This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Function: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. Ref.1 Ref.6 Ref.10 Ref.11 UniProtKB Q62011

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity. Cell projection › filopodium membrane; Single-pass type I membrane protein

By similarity. Cell projection › lamellipodium membrane; Single-pass type I membrane protein

By similarity. Cell projection › microvillus membrane; Single-pass type I membrane protein

By similarity. Cell projection › ruffle membrane; Single-pass type I membrane protein

By similarity. Note: Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles

By similarity. UniProtKB Q64294 UniProtKB Q62011

Tissue specificity: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas. Ref.2 Ref.6 Ref.10

Post-translational modification: Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity. Ref.2 Ref.6 Ref.11The N-terminus is blocked

By similarity. UniProtKB Q64294

Sequence similarities: Belongs to the podoplanin family.

Sequence caution: The sequence AAM73655.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAO22143.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAC11550.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAC11557.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAG35495.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.