Mouse Anti-TFR Monoclonal Antibody – Cat# MBS692536

Transferrin R (TFR) Antibody – Mouse Monoclonal

Name: TFR Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS692536
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS692536

Description: Transferrin receptors are transmembrane, homodimeric proteins that play a role in iron transport, uptake, and storage. TfR is an essential receptor, found on almost all cell types, regulated by intracellular iron concentration, and has a high… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Transferrin R (TFR), Monoclonal Antibody

Full Product Name

Anti-Human Transferrin R

Product Gene Name

anti-TFR antibody

Product Synonym Names

TFRC; T9; TR; p90; CD71; TFR1; TRFR

Clonality

Monoclonal

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized; PBS

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C.
Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

OMIM

190010

3D Structure

ModBase 3D Structure for P02786

Immunogen

Human recombinant TfR EC domain

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-TFR antibody

Flow Cytometry (FC/FACS)

Other Notes

Small volumes of anti-TFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFR purchase

MBS692536 is an antibody targeting TFR. Also known as Anti-Human Transferrin R. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TFR. It may not necessarily be applicable to this product.

NCBI GI #

189458819

NCBI GeneID

7037

NCBI Accession #

NP_001121620.1

UniProt Primary Accession #

P02786

UniProt Related Accession #

P02786

GenBank Nucleotide #

NM_003234.2

NCBI Official Full Name

transferrin receptor protein 1 isoform 1

NCBI Official Synonym Full Names

transferrin receptor

NCBI Official Symbol

TFRC

NCBI Official Synonym Symbols

T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46

UniProt Protein Name

Transferrin receptor protein 1

UniProt Synonym Protein Names

T9; p90

Protein Family

Transferrin receptor protein

UniProt Gene Name

TFRC

UniProt Synonym Gene Names

TR; TfR; TfR1; Trfr; sTfR

UniProt Entry Name

TFR1_HUMAN

NCBI Protein Information

transferrin receptor protein 1

NCBI Summary for TFR

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

UniProt Comments for TFR

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Membrane protein, integral; Receptor, misc.; Cell surface

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; melanosome; plasma membrane; vesicle; endosome; external side of plasma membrane

Molecular Function: identical protein binding; protein binding; transferrin receptor activity; double-stranded RNA binding

Biological Process: receptor-mediated endocytosis; viral reproduction; cellular iron ion homeostasis; positive regulation of bone resorption; transferrin transport; osteoclast differentiation; regulation of cell growth; transmembrane transport; regulation of cell proliferation

Research Articles on TFR

1. MiR-107 suppresses the proliferation, migration and invasion of SW620 cells by negatively regulating transferrin receptor 1 (TFR1).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TFR antibody

Reference Product	PubMed Publications
HFE antibody	>18 publications with TFR and HFE
CD4 antibody	>1 publications with TFR and CD4

Pathways associated with anti-TFR antibody

Products by Pathway	Pathway Diagram
Clathrin Derived Vesicle Budding Pathway antibodies	Clathrin Derived Vesicle Budding Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies	FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
Golgi Associated Vesicle Biogenesis Pathway antibodies	Golgi Associated Vesicle Biogenesis Pathway Diagram
HIF-1 Signaling Pathway antibodies	HIF-1 Signaling Pathway Diagram
HIF-1-alpha Transcription Factor Network Pathway antibodies	HIF-1-alpha Transcription Factor Network Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Iron Metabolism In Placenta Pathway antibodies	Iron Metabolism In Placenta Pathway Diagram

Diseases associated with anti-TFR antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>33 publications with TFR and Neoplasms
Iron Metabolism Disorders Antibodies	>28 publications with TFR and Iron Metabolism Disorders
Anemia Antibodies	>16 publications with TFR and Anemia
Disease Models, Animal Antibodies	>11 publications with TFR and Disease Models, Animal
Anemia, Iron-Deficiency Antibodies	>8 publications with TFR and Anemia, Iron-Deficiency
Lung Neoplasms Antibodies	>7 publications with TFR and Lung Neoplasms
Liver Diseases Antibodies	>6 publications with TFR and Liver Diseases
Brain Diseases Antibodies	>5 publications with TFR and Brain Diseases
Breast Neoplasms Antibodies	>4 publications with TFR and Breast Neoplasms
Drug Toxicity Antibodies	>4 publications with TFR and Drug Toxicity

Organs/Tissues associated with anti-TFR antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>34 publications with TFR and Blood
Liver Antibodies	>22 publications with TFR and Liver
Brain Antibodies	>16 publications with TFR and Brain
Intestine Antibodies	>11 publications with TFR and Intestine
Lung Antibodies	>10 publications with TFR and Lung
Bone Antibodies	>8 publications with TFR and Bone
Skin Antibodies	>7 publications with TFR and Skin
Kidney Antibodies	>7 publications with TFR and Kidney
Embryonic Tissue Antibodies	>6 publications with TFR and Embryonic Tissue
Prostate Antibodies	>5 publications with TFR and Prostate