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GM-CSF Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695097

Produced from sera of rabbits immunized with highly pure recombinant Rat GM-CSF. Anti-Rat GM-CSF specific antibody was purified by affinity chromatography employing an immobilized Rat GM-CSF matrix. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GM-CSF, Polyclonal Antibody
Full Product Name
Anti-rat GM-CSF
Product Gene Name
anti-GM-CSF antibody
Product Synonym Names
Anti-Rat GM-CSF
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Form/Format
Purified
Preparation and Storage
At -20 degree C
Molecular Weight
16,562 Da
3D Structure
ModBase 3D Structure for P48750
Immunogen
Recombinant Rat GM-CSF
Applications Tested/Suitable for anti-GM-CSF antibody
Neutralization, ELISA (EIA), Western Blot (WB)
Application Notes for anti-GM-CSF antibody
Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of Rat GM-CSF (0.5ng/ml), a concentration of 0.09-0.14 mug/ml of this antibody is required.

Sandwich ELISA: To detect Rat GM-CSF by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.5 - 2.0 mug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Rat GM-CSF as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat GM-CSF.

Western Blot: To detect Rat GM-CSF by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 mug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant Rat GM-CSF is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-GM-CSF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GM-CSF purchase

MBS695097 is an antibody targeting GM-CSF. Also known as Anti-rat GM-CSF. Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GM-CSF. It may not necessarily be applicable to this product.

NCBI GI #
215273996
NCBI GeneID
116630
NCBI Accession #
P48750.2
UniProt Primary Accession #
P48750
UniProt Related Accession #
P48750
NCBI Official Full Name
Granulocyte-macrophage colony-stimulating factor
NCBI Official Synonym Full Names
colony stimulating factor 2 (granulocyte-macrophage)
NCBI Official Symbol
Csf2
NCBI Official Synonym Symbols
Gmcsf; Gm-csf
UniProt Protein Name
Granulocyte-macrophage colony-stimulating factor
UniProt Synonym Protein Names
Colony-stimulating factor; CSF
Protein Family
Granulocyte colony-stimulating factor receptor
UniProt Gene Name
Csf2
UniProt Synonym Gene Names
Csfgm; GM-CSF; CSF
UniProt Entry Name
CSF2_RAT
NCBI Protein Information
granulocyte-macrophage colony-stimulating factor; CSF

NCBI Summary for GM-CSF

plays a role in alveolar epithelial fluid transport [RGD, Feb 2006]

UniProt Comments for GM-CSF

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity

Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; positive regulation of interleukin-23 production; myeloid dendritic cell differentiation; regulation of cell proliferation; macrophage activation; epithelial cell proliferation; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of gene expression; positive regulation of cell proliferation; immune response; positive regulation of macrophage differentiation; positive regulation of DNA replication
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Research Articles on GM-CSF

1. Expression of SCF+GM-CSF after hepatectomy can contribute to biliary remodeling (e.g., post-transplantation) by functional deregulation of the activity of key signaling intermediates involved in cell expansion and multipotent differentiation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GM-CSF antibody

 Reference Product  PubMed Publications
 Il6 antibody  >24 publications with GM-CSF and Il6
 Ccl2 antibody  >19 publications with GM-CSF and Ccl2
 Il4 antibody  >17 publications with GM-CSF and Il4
 Csf2rb antibody  >10 publications with GM-CSF and Csf2rb
 Il5 antibody  >10 publications with GM-CSF and Il5
 Il2 antibody  >9 publications with GM-CSF and Il2
 Il7 antibody  >4 publications with GM-CSF and Il7
 Stat3 antibody  >3 publications with GM-CSF and Stat3
 Cd80 antibody  >2 publications with GM-CSF and Cd80
 Fos antibody  >2 publications with GM-CSF and Fos

Pathways associated with anti-GM-CSF antibody

 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with anti-GM-CSF antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >38 publications with GM-CSF and Inflammation
 Necrosis Antibodies  >25 publications with GM-CSF and Necrosis
 Lung Diseases Antibodies  >9 publications with GM-CSF and Lung Diseases
 Breast Neoplasms Antibodies  >6 publications with GM-CSF and Breast Neoplasms
 Carcinoma Antibodies  >3 publications with GM-CSF and Carcinoma
 Leukemia, Myeloid, Acute Antibodies  >3 publications with GM-CSF and Leukemia, Myeloid, Acute
 Cardiovascular Diseases Antibodies  >3 publications with GM-CSF and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >3 publications with GM-CSF and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >3 publications with GM-CSF and Lung Neoplasms
 Arthritis, Rheumatoid Antibodies  >2 publications with GM-CSF and Arthritis, Rheumatoid
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