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TRAIL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695110

Produced from sera of rabbits immunized with highly pure recombinant Murine TRAIL. Anti-Murine TRAIL specific antibody was purified by affinity chromatography employing an immobilized Murine TRAIL matrix. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TRAIL, Polyclonal Antibody
Full Product Name
Anti-murine TRAIL
Product Gene Name
anti-TRAIL antibody
Product Synonym Names
Anti-Murine TRAIL
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Purified
Preparation and Storage
At -20 degree C
Molecular Weight
33,477 Da
3D Structure
ModBase 3D Structure for P50592
Immunogen
Recombinant Murine TRAIL
Applications Tested/Suitable for anti-TRAIL antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-TRAIL antibody
Sandwich ELISA: To detect Murine TRAIL by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.5 - 2.0 mug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine TRAIL as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Murine TRAIL.

Western Blot: To detect Murine TRAIL by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 mug/ml. When used in conjunction with compatible secondary reagents, the detection limit for recombinant Murine TRAIL is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-TRAIL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRAIL purchase

MBS695110 is an antibody targeting TRAIL. Also known as Anti-murine TRAIL. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TRAIL. It may not necessarily be applicable to this product.

NCBI GI #
1730016
NCBI GeneID
22035
NCBI Accession #
P50592.1
UniProt Primary Accession #
P50592
UniProt Related Accession #
P50592
NCBI Official Full Name
Tumor necrosis factor ligand superfamily member 10
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 10
NCBI Official Symbol
Tnfsf10
NCBI Official Synonym Symbols
TL2; Ly81; Trail; APO-2L; AI448571; A330042I21Rik
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 10
UniProt Synonym Protein Names
TNF-related apoptosis-inducing ligand; Protein TRAIL; CD_antigen: CD253
Protein Family
Tumor necrosis factor ligand superfamily
UniProt Gene Name
Tnfsf10
UniProt Synonym Gene Names
Trail; Protein TRAIL
UniProt Entry Name
TNF10_MOUSE
NCBI Protein Information
tumor necrosis factor ligand superfamily member 10; TRAIL/APO2L; TNF-related apoptosis inducing ligand; TNF-related apoptosis-inducing ligand

UniProt Comments for TRAIL

TRAIL: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Homotrimer. Widespread; most predominant in spleen, lung and prostate. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Membrane protein, integral

Cellular Component: extracellular space; membrane; integral to membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding

Biological Process: apoptosis; positive regulation of apoptosis; positive regulation of caspase activity; immune response
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Research Articles on TRAIL

1. These results suggest that TRAIL inhibits VEGF-induced angiogenesis by increasing caspase-8 activity and subsequently decreasing non-apoptotic signaling functions of procaspase-8, without inducing caspase-3 activation and endothelial cell cytotoxicity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRAIL antibody

 Reference Product  PubMed Publications
 Tnfrsf10b antibody  >2761 publications with TRAIL and Tnfrsf10b
 Casp8 antibody  >1291 publications with TRAIL and Casp8
 Fadd antibody  >630 publications with TRAIL and Fadd
 Cflar antibody  >255 publications with TRAIL and Cflar
 Tnfrsf11b antibody  >172 publications with TRAIL and Tnfrsf11b
 Ifnar1 antibody  >3 publications with TRAIL and Ifnar1
 Prdx4 antibody  >1 publications with TRAIL and Prdx4
 Tnfrsf23 antibody  >1 publications with TRAIL and Tnfrsf23
 Ifngr1 antibody  >1 publications with TRAIL and Ifngr1

Pathways associated with anti-TRAIL antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Signaling Pathway antibodies  Apoptosis Signaling Pathway Diagram
 Caspase-8 Activation By Cleavage Pathway antibodies  Caspase-8 Activation By Cleavage Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
 Dimerization Of Procaspase-8 Pathway antibodies  Dimerization Of Procaspase-8 Pathway Diagram

Diseases associated with anti-TRAIL antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3827 publications with TRAIL and Necrosis
 Leukemia Antibodies  >464 publications with TRAIL and Leukemia
 Colorectal Neoplasms Antibodies  >342 publications with TRAIL and Colorectal Neoplasms
 Liver Diseases Antibodies  >336 publications with TRAIL and Liver Diseases
 Breast Neoplasms Antibodies  >311 publications with TRAIL and Breast Neoplasms
 Liver Neoplasms Antibodies  >295 publications with TRAIL and Liver Neoplasms
 Lung Neoplasms Antibodies  >289 publications with TRAIL and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >281 publications with TRAIL and Neoplasms, Experimental
 Inflammation Antibodies  >267 publications with TRAIL and Inflammation
 Glioma Antibodies  >247 publications with TRAIL and Glioma

Organs/Tissues associated with anti-TRAIL antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >459 publications with TRAIL and Liver
 Lung Antibodies  >388 publications with TRAIL and Lung
 Kidney Antibodies  >154 publications with TRAIL and Kidney
 Bone Marrow Antibodies  >112 publications with TRAIL and Bone Marrow
 Muscle Antibodies  >77 publications with TRAIL and Muscle
 Spleen Antibodies  >71 publications with TRAIL and Spleen
 Mixed Antibodies  >31 publications with TRAIL and Mixed
 Thymus Antibodies  >26 publications with TRAIL and Thymus
 Spinal Cord Antibodies  >12 publications with TRAIL and Spinal Cord
 Mammary Gland Antibodies  >7 publications with TRAIL and Mammary Gland
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