Rabbit Anti-GRO-beta/MIP-2 Polyclonal Antibody – Cat# MBS695147

Grobeta / MIP-2 (GRO-beta/MIP-2) Antibody – Rabbit Polyclonal

Name: GRO-beta/MIP-2 Antibody; Polyclonal; Rabbit; Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS695147
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695147

Produced from sera of rabbits pre-immunized with highly pure recombinant Rat GRObeta/MIP-2. Anti-Rat GRObeta/MIP-2 specific antibody was purified by affinity chromatography employing immobilized Rat GRObeta/MIP-2 matrix. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GRObeta / MIP-2 (GRO-beta/MIP-2), Polyclonal Antibody

Full Product Name

Anti-rat GRObeta / MIP-2

Product Gene Name

anti-GRO-beta/MIP-2 antibody

Product Synonym Names

Anti-Rat GRO-beta/MIP-2

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Rat

Form/Format

Purified

Preparation and Storage

At -20 degree C

Molecular Weight

10,783 Da

3D Structure

ModBase 3D Structure for P30348

Immunogen

Recombinant Rat GRO-beta/MIP-2

Applications Tested/Suitable for anti-GRO-beta/MIP-2 antibody

Neutralization, ELISA (EIA), Western Blot (WB)

Application Notes for anti-GRO-beta/MIP-2 antibody

Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of Rat GRObeta/MIP-2 (100 ng/ml), a concentration of 3.0-5.0 ug/ml of this antibody is required.

Sandwich ELISA: To detect Rat GRObeta/MIP-2 by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.5 - 2.0 mug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Rat GRObeta/MIP-2 as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat GRObeta/MIP-2.

Western Blot: To detect Rat GRObeta/MIP-2 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 ug/ml. When used in conjunction with compatible secondary reagents, the detection limit for recombinant Rat GRObeta/MIP-2 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-GRO-beta/MIP-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRO-beta/MIP-2 purchase

MBS695147 is an antibody targeting GRO-beta/MIP-2. Also known as Anti-rat GRObeta / MIP-2. Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GRO-beta/MIP-2. It may not necessarily be applicable to this product.

NCBI GI #

266536

NCBI GeneID

114105

NCBI Accession #

P30348.1

UniProt Primary Accession #

P30348

UniProt Secondary Accession #

Q5WA60

UniProt Related Accession #

P30348

NCBI Official Full Name

C-X-C motif chemokine 2

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 2

NCBI Official Symbol

Cxcl2

NCBI Official Synonym Symbols

Mip-2; Scyb2

UniProt Protein Name

C-X-C motif chemokine 2

UniProt Synonym Protein Names

Cytokine-induced neutrophil chemoattractant 3; CINC-3; Macrophage inflammatory protein 2; MIP2

UniProt Gene Name

Cxcl2

UniProt Synonym Gene Names

Cinc3; Mip-2; Mip2; Scyb2; CINC-3; MIP2

UniProt Entry Name

CXCL2_RAT

NCBI Protein Information

C-X-C motif chemokine 2; MIP2; CINC-3; macrophage inflammatory protein 2; small inducible cytokine subfamily, member 2; cytokine-induced neutrophil chemoattractant 3

NCBI Summary for GRO-beta/MIP-2

chemokine involved in the pulmonary inflammatory response [RGD, Feb 2006]

UniProt Comments for GRO-beta/MIP-2

CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Cellular Component: extracellular space

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; neutrophil chemotaxis; elevation of cytosolic calcium ion concentration; wound healing; response to heat; response to molecule of bacterial origin; leukocyte chemotaxis; response to glucocorticoid stimulus; response to amphetamine; response to gamma radiation; positive regulation of leukocyte chemotaxis; immune response; inflammatory response; response to estradiol stimulus; regulation of cell proliferation

Research Articles on GRO-beta/MIP-2

1. IL-1beta-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic beta-cells requires stimulus-induced changes in histone chemical modifications, recruitment of the NF-kappaB and STAT1 transcription factors to genomic regulatory sequences within the proximal gene promoters, and increases in phosphorylated forms of RNA polymerase II.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRO-beta/MIP-2 antibody

Reference Product	PubMed Publications
Cxcl1 antibody	>557 publications with GRO-beta/MIP-2 and Cxcl1
Ccl2 antibody	>373 publications with GRO-beta/MIP-2 and Ccl2
Il8rb antibody	>117 publications with GRO-beta/MIP-2 and Il8rb
Cxcl3 antibody	>99 publications with GRO-beta/MIP-2 and Cxcl3
Cxcr4 antibody	>44 publications with GRO-beta/MIP-2 and Cxcr4
Ccr2 antibody	>42 publications with GRO-beta/MIP-2 and Ccr2
Cxcl6 antibody	>36 publications with GRO-beta/MIP-2 and Cxcl6
Ccr1 antibody	>25 publications with GRO-beta/MIP-2 and Ccr1
Cxcr3 antibody	>18 publications with GRO-beta/MIP-2 and Cxcr3
Ppbp antibody	>3 publications with GRO-beta/MIP-2 and Ppbp

Pathways associated with anti-GRO-beta/MIP-2 antibody

Products by Pathway	Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Legionellosis Pathway antibodies	Legionellosis Pathway Diagram
Legionellosis Pathway antibodies	Legionellosis Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
NOD-like Receptor Signaling Pathway antibodies	NOD-like Receptor Signaling Pathway Diagram
NOD-like Receptor Signaling Pathway antibodies	NOD-like Receptor Signaling Pathway Diagram
PI3K_AKT_NFKB Pathway antibodies	PI3K_AKT_NFKB Pathway Diagram

Diseases associated with anti-GRO-beta/MIP-2 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>1008 publications with GRO-beta/MIP-2 and Inflammation
Necrosis Antibodies	>643 publications with GRO-beta/MIP-2 and Necrosis
Lung Diseases Antibodies	>383 publications with GRO-beta/MIP-2 and Lung Diseases
Disease Models, Animal Antibodies	>355 publications with GRO-beta/MIP-2 and Disease Models, Animal
Lung Injury Antibodies	>259 publications with GRO-beta/MIP-2 and Lung Injury
Pneumonia Antibodies	>173 publications with GRO-beta/MIP-2 and Pneumonia
Reperfusion Injury Antibodies	>115 publications with GRO-beta/MIP-2 and Reperfusion Injury
Wounds and Injuries Antibodies	>95 publications with GRO-beta/MIP-2 and Wounds and Injuries
Edema Antibodies	>92 publications with GRO-beta/MIP-2 and Edema
Skin Diseases Antibodies	>81 publications with GRO-beta/MIP-2 and Skin Diseases

Organs/Tissues associated with anti-GRO-beta/MIP-2 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>624 publications with GRO-beta/MIP-2 and Lung
Connective Tissue Antibodies	>28 publications with GRO-beta/MIP-2 and Connective Tissue