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I-309 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695316

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hI-309. Anti-Human I-309 specific antibody was purified by affinity chromatography employing immobilized hI-309 matrix. More details

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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
I-309, Polyclonal Antibody
Full Product Name
Anti-human I-309
Product Gene Name
anti-I-309 antibody
Product Synonym Names
Anti-Human I-309
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified
Preparation and Storage
At -20 degree C
Molecular Weight
10,992 Da
OMIM
182281
3D Structure
ModBase 3D Structure for P22362
Immunogen
Recombinant Human I-309
Applications Tested/Suitable for anti-I-309 antibody
Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-I-309 antibody
Immunohistochemistery: This antibody stained formalin-fixed, paraffin-embedded sections of human normal pancreas. The recommended concentration is 0.25 ug/mL- 0.50 ug/mL with an overnight incubation at 4 degree C. An HRP-labeled polymer detection system was used with a DAB chromogen. Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended.

Sandwich ELISA: To detect hI-309 by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.5 - 2.0 mug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human I-309 as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hI-309.

Western Blot: To detect human I-309 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 ug/ml. When used in conjunction with compatible secondary reagents, the detection limit for recombinant human I-309 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-I-309 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for I-309 purchase

MBS695316 is an antibody targeting I-309. Also known as Anti-human I-309. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for I-309. It may not necessarily be applicable to this product.

NCBI GI #
123950
NCBI GeneID
6346
NCBI Accession #
P22362.1
UniProt Primary Accession #
P22362
UniProt Secondary Accession #
Q2M309; B2R5G9
UniProt Related Accession #
P22362
NCBI Official Full Name
C-C motif chemokine 1
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 1
NCBI Official Symbol
CCL1
NCBI Official Synonym Symbols
P500; SISe; TCA3; I-309; SCYA1
UniProt Protein Name
C-C motif chemokine 1
UniProt Synonym Protein Names
Small-inducible cytokine A1; T lymphocyte-secreted protein I-309
Protein Family
Putative defensin-like protein
UniProt Gene Name
CCL1
UniProt Synonym Gene Names
SCYA1
UniProt Entry Name
CCL1_HUMAN
NCBI Protein Information
C-C motif chemokine 1; inflammatory cytokine I-309; T lymphocyte-secreted protein I-309; small inducible cytokine A1 (I-309, homologous to mouse Tca-3)

NCBI Summary for I-309

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]
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UniProt Comments for I-309

CCL1: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Chemokine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space

Molecular Function: chemokine activity

Biological Process: cellular calcium ion homeostasis; viral reproduction; immune response; chemotaxis; signal transduction
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Research Articles on I-309

1. CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-I-309 antibody

 Reference Product  PubMed Publications
 CCR8 antibody  >101 publications with I-309 and CCR8
 CCR5 antibody  >23 publications with I-309 and CCR5
 CXCR3 antibody  >13 publications with I-309 and CXCR3
 CCR1 antibody  >13 publications with I-309 and CCR1
 CCR3 antibody  >12 publications with I-309 and CCR3
 CCR2 antibody  >8 publications with I-309 and CCR2
 CCR7 antibody  >7 publications with I-309 and CCR7
 CCR6 antibody  >6 publications with I-309 and CCR6
 CX3CR1 antibody  >5 publications with I-309 and CX3CR1

Pathways associated with anti-I-309 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with anti-I-309 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >74 publications with I-309 and Immune System Diseases
 Inflammation Antibodies  >72 publications with I-309 and Inflammation
 Necrosis Antibodies  >35 publications with I-309 and Necrosis
 Lung Diseases Antibodies  >21 publications with I-309 and Lung Diseases
 Nervous System Diseases Antibodies  >21 publications with I-309 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >10 publications with I-309 and Cardiovascular Diseases
 Liver Diseases Antibodies  >6 publications with I-309 and Liver Diseases
 Kidney Diseases Antibodies  >6 publications with I-309 and Kidney Diseases
 Atherosclerosis Antibodies  >5 publications with I-309 and Atherosclerosis
 Carcinoma Antibodies  >3 publications with I-309 and Carcinoma

Organs/Tissues associated with anti-I-309 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >23 publications with I-309 and Lung
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