Rabbit Anti-MEC Polyclonal Antibody – Cat# MBS695402

MEC Antibody – Rabbit Polyclonal

Name: MEC Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS695402
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695402

Produced from sera of rabbits immunized with highly pure recombinant Human MEC. Anti-Human MEC specific antibody was purified by affinity chromatography and then biotinylated. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MEC, Polyclonal Antibody

Full Product Name

Biotinylated Anti-hMEC

Product Gene Name

anti-MEC antibody

Product Synonym Names

Biotinylated Anti-Human MEC

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Biotin

Preparation and Storage

At -20 degree C

Molecular Weight

12,375 Da

OMIM

605240

3D Structure

ModBase 3D Structure for Q9NRJ3

Immunogen

Recombinant Human MEC

Applications Tested/Suitable for anti-MEC antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-MEC antibody

Direct Detection: To detect hMEC by direct ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hMEC.

Sandwich ELISA: To detect hMEC by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with Polyclonal Anti-Human MEC as a capture antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hMEC.

Western Blot: To detect hMEC by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 mug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hMEC is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-MEC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MEC purchase

MBS695402 is an antibody targeting MEC. Also known as Biotinylated Anti-hMEC. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MEC. It may not necessarily be applicable to this product.

NCBI GI #

12230650

NCBI GeneID

56477

NCBI Accession #

Q9NRJ3.1

UniProt Primary Accession #

Q9NRJ3

UniProt Secondary Accession #

D7RIE7

UniProt Related Accession #

Q9NRJ3

NCBI Official Full Name

C-C motif chemokine 28

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 28

NCBI Official Symbol

CCL28

NCBI Official Synonym Symbols

MEC; CCK1; SCYA28

UniProt Protein Name

C-C motif chemokine 28

UniProt Synonym Protein Names

Mucosae-associated epithelial chemokine; MEC; Protein CCK1; Small-inducible cytokine A28

Protein Family

CysO-cysteine peptidase

UniProt Gene Name

CCL28

UniProt Synonym Gene Names

SCYA28; MEC

UniProt Entry Name

CCL28_HUMAN

NCBI Protein Information

C-C motif chemokine 28; CC chemokine CCL28; small inducible cytokine A28; small-inducible cytokine A28; mucosae-associated epithelial chemokine; chemokine (C-C motif) ligand 28 splice variant chi; small inducible cytokine subfamily A (Cys-Cys), member 28

NCBI Summary for MEC

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

UniProt Comments for MEC

CCL28: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5p12

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity

Biological Process: elevation of cytosolic calcium ion concentration; immune response; chemotaxis; positive regulation of cell-matrix adhesion; response to nutrient

Research Articles on MEC

1. CCL28 is a potent growth-promoting factor with the ability to support the in vitro and in vivo functional properties of cultured human hematopoietic cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MEC antibody

Reference Product	PubMed Publications
CCR10 antibody	>49 publications with MEC and CCR10
CCR3 antibody	>17 publications with MEC and CCR3
CCL21 antibody	>13 publications with MEC and CCL21
CCL20 antibody	>11 publications with MEC and CCL20
CXCL13 antibody	>7 publications with MEC and CXCL13
CCR7 antibody	>6 publications with MEC and CCR7
CXCL11 antibody	>2 publications with MEC and CXCL11
CXCR5 antibody	>2 publications with MEC and CXCR5
CCL16 antibody	>1 publications with MEC and CCL16

Pathways associated with anti-MEC antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram

Diseases associated with anti-MEC antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>27 publications with MEC and Inflammation
Necrosis Antibodies	>11 publications with MEC and Necrosis
Disease Models, Animal Antibodies	>7 publications with MEC and Disease Models, Animal
Vascular Diseases Antibodies	>6 publications with MEC and Vascular Diseases
Carcinoma Antibodies	>6 publications with MEC and Carcinoma
Adenocarcinoma Antibodies	>6 publications with MEC and Adenocarcinoma
Liver Diseases Antibodies	>5 publications with MEC and Liver Diseases
Hypertension Antibodies	>2 publications with MEC and Hypertension
Kidney Diseases Antibodies	>2 publications with MEC and Kidney Diseases
Neoplasms, Experimental Antibodies	>2 publications with MEC and Neoplasms, Experimental

Organs/Tissues associated with anti-MEC antibody

Organ/Tissue Name	Pubmed Publications
Mammary Gland Antibodies	>11 publications with MEC and Mammary Gland
Thymus Antibodies	>9 publications with MEC and Thymus
Liver Antibodies	>8 publications with MEC and Liver
Brain Antibodies	>6 publications with MEC and Brain
Bone Marrow Antibodies	>4 publications with MEC and Bone Marrow
Trachea Antibodies	>4 publications with MEC and Trachea
Stomach Antibodies	>4 publications with MEC and Stomach
Pharynx Antibodies	>4 publications with MEC and Pharynx
Muscle Antibodies	>2 publications with MEC and Muscle
Placenta Antibodies	>1 publications with MEC and Placenta