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Resistin (RETN) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695404

Produced from sera of goats pre-immunized with highly pure (>98%) recombinant hResistin. Anti-Human Resistin specific antibody was purified by affinity chromatography employing immobilized hResistin matrix. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Resistin (RETN), Polyclonal Antibody
Full Product Name
Anti-human Resistin
Product Gene Name
anti-RETN antibody
Product Synonym Names
Anti-Human Resistin
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Form/Format
Purified
Preparation and Storage
At -20 degree C
Molecular Weight
8,686 Da
OMIM
605565
3D Structure
ModBase 3D Structure for Q9HD89
Immunogen
Recombinant Human Resistin
Applications Tested/Suitable for anti-RETN antibody
Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-RETN antibody
Immunohistochemistery: This antibody stained formalin-fixed, paraffin-embedded sections of human normal placenta. The recommended concentration is 1.0 mg/ml with a two hour incubation at room temperature. An HRP-labeled polymer detection system was used with a DAB chromogen. Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended.

Sandwich ELISA: To detect hResistin by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.5 - 2.0 mug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human Resistin as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hResistin.

Western Blot: To detect hResistin by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hResistin is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-RETN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RETN purchase

MBS695404 is an antibody targeting RETN. Also known as Anti-human Resistin. Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for RETN. It may not necessarily be applicable to this product.

NCBI GI #
18202962
NCBI GeneID
56729
NCBI Accession #
Q9HD89.1
UniProt Primary Accession #
Q9HD89
UniProt Secondary Accession #
Q540D9; Q76B53; D6W649
UniProt Related Accession #
Q9HD89
NCBI Official Full Name
Resistin
NCBI Official Synonym Full Names
resistin
NCBI Official Symbol
RETN
NCBI Official Synonym Symbols
ADSF; RSTN; XCP1; FIZZ3; RETN1
UniProt Protein Name
Resistin
UniProt Synonym Protein Names
Adipose tissue-specific secretory factor; ADSF; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2; Cysteine-rich secreted protein FIZZ3
Protein Family
Protein dead ringer
UniProt Gene Name
RETN
UniProt Synonym Gene Names
FIZZ3; HXCP1; RSTN; ADSF
UniProt Entry Name
RETN_HUMAN
NCBI Protein Information
resistin; resistin delta2; found in inflammatory zone 3; cysteine-rich secreted protein FIZZ3; adipose tissue-specific secretory factor; cysteine-rich secreted protein A12-alpha-like 2; c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1

NCBI Summary for RETN

This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
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UniProt Comments for RETN

resistin: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes. Belongs to the resistin/FIZZ family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular space; nucleus

Molecular Function: hormone activity

Biological Process: fat cell differentiation; response to mechanical stimulus; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle cell migration; positive regulation of synaptic transmission; aging; response to insulin stimulus

Disease: Diabetes Mellitus, Noninsulin-dependent
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Research Articles on RETN

1. Leptin and resistin may represent the principal mediators of the impact of obesity on the inflammatory markers involved in cardiovascular risk in type 2 diabetes patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RETN antibody

 Reference Product  PubMed Publications
 LEP antibody  >9 publications with RETN and LEP
 SOCS3 antibody  >6 publications with RETN and SOCS3
 GHRL antibody  >5 publications with RETN and GHRL
 CD36 antibody  >4 publications with RETN and CD36
 NPY antibody  >3 publications with RETN and NPY
 AKT1 antibody  >2 publications with RETN and AKT1
 INSR antibody  >2 publications with RETN and INSR
 INS antibody  >2 publications with RETN and INS
 IGF1 antibody  >1 publications with RETN and IGF1

Pathways associated with anti-RETN antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram

Diseases associated with anti-RETN antibody

 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >333 publications with RETN and Insulin Resistance
 Inflammation Antibodies  >114 publications with RETN and Inflammation
 Cardiovascular Diseases Antibodies  >107 publications with RETN and Cardiovascular Diseases
 Diabetes Mellitus, Type 2 Antibodies  >102 publications with RETN and Diabetes Mellitus, Type 2
 Necrosis Antibodies  >100 publications with RETN and Necrosis
 Atherosclerosis Antibodies  >58 publications with RETN and Atherosclerosis
 Hypertension Antibodies  >35 publications with RETN and Hypertension
 Metabolic Syndrome X Antibodies  >32 publications with RETN and Metabolic Syndrome X
 Heart Diseases Antibodies  >30 publications with RETN and Heart Diseases
 Coronary Disease Antibodies  >29 publications with RETN and Coronary Disease

Organs/Tissues associated with anti-RETN antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >382 publications with RETN and Blood
 Intestine Antibodies  >10 publications with RETN and Intestine
 Placenta Antibodies  >8 publications with RETN and Placenta
 Bone Marrow Antibodies  >5 publications with RETN and Bone Marrow
 Eye Antibodies  >2 publications with RETN and Eye
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