Goat Anti-LD78beta Polyclonal Antibody – Cat# MBS695405

LD78beta Antibody – Goat Polyclonal

Name: LD78beta Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS695405
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695405

Produced from sera of goats pre-immunized with highly pure recombinant Human LD78beta. Anti-Human LD78beta specific antibody was purified by affinity chromatography employing immobilized Human LD78beta matrix. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

LD78beta, Polyclonal Antibody

Full Product Name

Anti-human LD78beta

Product Gene Name

anti-LD78beta antibody

Product Synonym Names

Anti-Human LD78beta

Clonality

Polyclonal

Host

Goat

Species Reactivity

Human

Form/Format

Purified

Preparation and Storage

At -20 degree C

Molecular Weight

10,161 Da

OMIM

gene 609468

3D Structure

ModBase 3D Structure for P16619

Immunogen

Recombinant Human LD78beta

Applications Tested/Suitable for anti-LD78beta antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-LD78beta antibody

Sandwich ELISA: To detect Human LD78beta by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.5 - 2.0 mug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human LD78beta as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human LD78beta.

Western Blot: To detect Human LD78beta by Western Blot analysis this antibody can be used at a concentration of 0.1- 0.2 ug/ml. When used in conjunction with compatible secondary reagents, the detection limit for recombinant Human LD78beta is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-LD78beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LD78beta purchase

MBS695405 is an antibody targeting LD78beta. Also known as Anti-human LD78beta. Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for LD78beta. It may not necessarily be applicable to this product.

NCBI GI #

127077

NCBI GeneID

414062

NCBI Accession #

P16619.1

UniProt Primary Accession #

P16619

UniProt Secondary Accession #

Q3B7A8; Q53YA5; Q96I68; A6NGK6; B2RUX4

UniProt Related Accession #

P16619

NCBI Official Full Name

C-C motif chemokine 3-like 1

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 3-like 3

NCBI Official Symbol

CCL3L3

NCBI Official Synonym Symbols

LD78; 464.2; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA

UniProt Protein Name

C-C motif chemokine 3-like 1

UniProt Synonym Protein Names

G0/G1 switch regulatory protein 19-2; LD78-beta(1-70); PAT 464.2; Small-inducible cytokine A3-like 1; Tonsillar lymphocyte LD78 beta proteinCleaved into the following 2 chains:LD78-beta(3-70); LD78-beta(5-70)

UniProt Gene Name

CCL3L1

UniProt Synonym Gene Names

D17S1718; G0S19-2; SCYA3L1

UniProt Entry Name

CL3L1_HUMAN

NCBI Protein Information

C-C motif chemokine 3-like 1; LD78-beta(1-70); small inducible cytokine A3-like 1; G0/G1 switch regulatory protein 19-2; tonsillar lymphocyte LD78 beta protein; chemokine (C-C motif) ligand 3-like, centromeric

NCBI Summary for LD78beta

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]

UniProt Comments for LD78beta

CCL3L1: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1- infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity

Biological Process: negative regulation of cell proliferation; immune response; inflammatory response

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To

Research Articles on LD78beta

1. severe periodontal tissue destruction in Papillon-Lefevre syndrome may be related to excess accumulation of LD78beta and LD78alpha and dysregulation of the microbial-induced inflammatory response in the periodontium

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-LD78beta antibody

Products by Pathway	Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-LD78beta antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>1 publications with LD78beta and Cardiovascular Diseases
Myocardial Infarction Antibodies	>1 publications with LD78beta and Myocardial Infarction

Organs/Tissues associated with anti-LD78beta antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>1 publications with LD78beta and Bone