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GRO-gamma Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695440

Produced from sera of rabbits pre-immunized with highly pure recombinant Human GRO-gamma. Anti-Human GRO-gamma specific antibody was purified by affinity chromatography and then biotinylated. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GROgamma (GRO-gamma), Polyclonal Antibody
Full Product Name
Biotinylated Anti-hGROgamma
Product Gene Name
anti-GRO-gamma antibody
Product Synonym Names
Biotinylated Anti-Human GRO-gamma
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Biotin
Preparation and Storage
At -20 degree C
Molecular Weight
11,342 Da
OMIM
139111
3D Structure
ModBase 3D Structure for P19876
Immunogen
Recombinant Human GRO-gamma
Applications Tested/Suitable for anti-GRO-gamma antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-GRO-gamma antibody
Direct Detection: To detect Human GRO-gamma by direct ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human GRO-gamma.

Sandwich ELISA: To detect Human GRO-gamma by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with Polyclonal Anti-Human GRO-gamma as a capture antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human GRO-gamma.

Western Blot: To detect Human GRO-gamma by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant Human GRO-gamma is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-GRO-gamma antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRO-gamma purchase

MBS695440 is an antibody targeting GRO-gamma. Also known as Biotinylated Anti-hGROgamma. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GRO-gamma. It may not necessarily be applicable to this product.

NCBI GI #
127086
NCBI GeneID
2921
NCBI Accession #
P19876.1
UniProt Primary Accession #
P19876
UniProt Secondary Accession #
Q4W5H9
UniProt Related Accession #
P19876
NCBI Official Full Name
C-X-C motif chemokine 3
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 3
NCBI Official Symbol
CXCL3
NCBI Official Synonym Symbols
GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b
UniProt Protein Name
C-X-C motif chemokine 3
UniProt Synonym Protein Names
GRO-gamma(1-73); Growth-regulated protein gamma; GRO-gamma; Macrophage inflammatory protein 2-beta; MIP2-beta
UniProt Gene Name
CXCL3
UniProt Synonym Gene Names
GRO3; GROG; SCYB3; GRO-gamma; MIP2-beta
UniProt Entry Name
CXCL3_HUMAN
NCBI Protein Information
C-X-C motif chemokine 3; GRO-gamma; MIP2-beta; MGSA gamma; GRO3 oncogene; GRO-gamma(1-73); growth-regulated protein gamma; macrophage inflammatory protein 2-beta; melanoma growth stimulatory activity gamma

NCBI Summary for GRO-gamma

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
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UniProt Comments for GRO-gamma

CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; neutrophil chemotaxis; immune response; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; inflammatory response; regulation of cell proliferation
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Research Articles on GRO-gamma

1. CXCL3 displays antimicrobial activity against E. coli and S. aureus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRO-gamma antibody

 Reference Product  PubMed Publications
 CXCL2 antibody  >99 publications with GRO-gamma and CXCL2
 CXCL1 antibody  >98 publications with GRO-gamma and CXCL1
 CCL20 antibody  >41 publications with GRO-gamma and CCL20
 CCL5 antibody  >26 publications with GRO-gamma and CCL5
 CXCR2 antibody  >11 publications with GRO-gamma and CXCR2
 CXCR1 antibody  >8 publications with GRO-gamma and CXCR1
 CXCL16 antibody  >6 publications with GRO-gamma and CXCL16
 CCL19 antibody  >6 publications with GRO-gamma and CCL19
 CCR1 antibody  >3 publications with GRO-gamma and CCR1
 CCL16 antibody  >1 publications with GRO-gamma and CCL16

Pathways associated with anti-GRO-gamma antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram

Diseases associated with anti-GRO-gamma antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >71 publications with GRO-gamma and Inflammation
 Necrosis Antibodies  >34 publications with GRO-gamma and Necrosis
 Respiratory Tract Diseases Antibodies  >13 publications with GRO-gamma and Respiratory Tract Diseases
 Lung Diseases Antibodies  >13 publications with GRO-gamma and Lung Diseases
 Immune System Diseases Antibodies  >11 publications with GRO-gamma and Immune System Diseases
 Skin Diseases Antibodies  >8 publications with GRO-gamma and Skin Diseases
 Fibrosis Antibodies  >6 publications with GRO-gamma and Fibrosis
 Death Antibodies  >6 publications with GRO-gamma and Death
 Kidney Diseases Antibodies  >4 publications with GRO-gamma and Kidney Diseases
 Neoplasms, Experimental Antibodies  >4 publications with GRO-gamma and Neoplasms, Experimental

Organs/Tissues associated with anti-GRO-gamma antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >62 publications with GRO-gamma and Blood
 Lung Antibodies  >16 publications with GRO-gamma and Lung
 Intestine Antibodies  >11 publications with GRO-gamma and Intestine
 Brain Antibodies  >8 publications with GRO-gamma and Brain
 Embryonic Tissue Antibodies  >4 publications with GRO-gamma and Embryonic Tissue
 Liver Antibodies  >4 publications with GRO-gamma and Liver
 Uterus Antibodies  >2 publications with GRO-gamma and Uterus
 Pancreas Antibodies  >1 publications with GRO-gamma and Pancreas
 Bladder Antibodies  >1 publications with GRO-gamma and Bladder
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