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IP-10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695455

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant mIP-10. Anti-Murine IP-10 specific antibody was purified by affinity chromatography and then biotinylated. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IP-10, Polyclonal Antibody
Full Product Name
Biotinylated Anti-mIP-10
Product Gene Name
anti-IP-10 antibody
Product Synonym Names
Biotinylated Anti-Murine IP-10
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Biotin
Preparation and Storage
At -20 degree C
Molecular Weight
10,789 Da
3D Structure
ModBase 3D Structure for P17515
Immunogen
Recombinant Murine IP-10
Applications Tested/Suitable for anti-IP-10 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-IP-10 antibody
Direct Detection: To detect mIP-10 by direct ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mIP-10.

Sandwich ELISA: To detect mIP-10 by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with Polyclonal Anti-Murine IP-10 as a capture antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mIP-10.

Western Blot: To detect mIP-10 by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant mIP-10 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-IP-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IP-10 purchase

MBS695455 is an antibody targeting IP-10. Also known as Biotinylated Anti-mIP-10. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IP-10. It may not necessarily be applicable to this product.

NCBI GI #
124494
NCBI GeneID
15945
NCBI Accession #
P17515.1
UniProt Primary Accession #
P17515
UniProt Related Accession #
P17515
NCBI Official Full Name
C-X-C motif chemokine 10
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 10
NCBI Official Symbol
Cxcl10
NCBI Official Synonym Symbols
C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10
UniProt Protein Name
C-X-C motif chemokine 10
UniProt Synonym Protein Names
10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10
UniProt Gene Name
Cxcl10
UniProt Synonym Gene Names
Crg2; Ifi10; Inp10; Scyb10; Gamma-IP10; IP-10
UniProt Entry Name
CXL10_MOUSE
NCBI Protein Information
C-X-C motif chemokine 10; gamma-IP10; interferon activated gene 10; small-inducible cytokine B10; interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; 10 kDa interferon gamma-induced protein; small inducible cytokine B subfamily (Cys-X-Cys), member 10

UniProt Comments for IP-10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis

Cellular Component: extracellular space; cell; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of cAMP metabolic process; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; negative regulation of myoblast differentiation; defense response to virus; positive regulation of cell migration
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Research Articles on IP-10

1. data indicate that epithelium-expressed CXCL10 plays a critical role in fungal clearance and that CXCR3-expressing NK cells contribute to CA eradication in mouse corneas.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IP-10 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with anti-IP-10 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1119 publications with IP-10 and Inflammation
 Necrosis Antibodies  >650 publications with IP-10 and Necrosis
 Lung Diseases Antibodies  >319 publications with IP-10 and Lung Diseases
 Liver Diseases Antibodies  >220 publications with IP-10 and Liver Diseases
 Cardiovascular Diseases Antibodies  >161 publications with IP-10 and Cardiovascular Diseases
 Fibrosis Antibodies  >123 publications with IP-10 and Fibrosis
 Neoplasms, Experimental Antibodies  >110 publications with IP-10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >83 publications with IP-10 and Kidney Diseases
 Lung Injury Antibodies  >61 publications with IP-10 and Lung Injury
 Pneumonia Antibodies  >59 publications with IP-10 and Pneumonia

Organs/Tissues associated with anti-IP-10 antibody

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >155 publications with IP-10 and Lymph Node
 Spleen Antibodies  >127 publications with IP-10 and Spleen
 Bone Marrow Antibodies  >121 publications with IP-10 and Bone Marrow
 Eye Antibodies  >90 publications with IP-10 and Eye
 Intestine Antibodies  >87 publications with IP-10 and Intestine
 Embryonic Tissue Antibodies  >52 publications with IP-10 and Embryonic Tissue
 Thymus Antibodies  >52 publications with IP-10 and Thymus
 Mammary Gland Antibodies  >8 publications with IP-10 and Mammary Gland
 Epididymis Antibodies  >1 publications with IP-10 and Epididymis
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