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IP-10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695459

Produced from sera of rabbits immunized with highly pure recombinant Rat IP-10. Anti-Rat IP-10 specific antibody was purified by affinity chromatography employing an immobilized Rat IP-10 matrix. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IP-10, Polyclonal Antibody
Full Product Name
Anti-rat IP-10
Product Gene Name
anti-IP-10 antibody
Product Synonym Names
Anti-Rat IP-10
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Form/Format
Purified
Preparation and Storage
At -20 degree C
Molecular Weight
10,729 Da
3D Structure
ModBase 3D Structure for P48973
Immunogen
Recombinant Rat IP-10
Applications Tested/Suitable for anti-IP-10 antibody
Immunohistochemistery (IHC), Neutralization, ELISA (EIA), Western Blot (WB)
Application Notes for anti-IP-10 antibody
Immunohistochemistery: This antibody stained colchicine injected rat brain (including the caudate putamen) tissue. The primary antibody was incubated at 0.25 mug/ml overnight at 4 degree C. This was followed by a peroxidase conjugated secondary antibody and then a fluorescein Tyramide Signal Amplification (TSA™) reagent. Information and photo are courtesy of the Tissue Profiling group, SciLifeLab Stockholm.

Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of Rat IP-10 (100 ng/ml), a concentration of 5.0-10.0 mug/ml of this antibody is required.

Sandwich ELISA: To detect Rat IP-10 by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.5 - 2.0 mug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Rat IP-10 as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat IP-10.

Western Blot: To detect Rat IP-10 by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 mug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant Rat IP-10 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-IP-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IP-10 purchase

MBS695459 is an antibody targeting IP-10. Also known as Anti-rat IP-10. Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IP-10. It may not necessarily be applicable to this product.

NCBI GI #
146345511
NCBI GeneID
245920
NCBI Accession #
P48973.2
UniProt Primary Accession #
P48973
UniProt Secondary Accession #
P70538; Q6GTC7
UniProt Related Accession #
P48973
NCBI Official Full Name
C-X-C motif chemokine 10
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 10
NCBI Official Symbol
Cxcl10
NCBI Official Synonym Symbols
IP-10; Scyb10
UniProt Protein Name
C-X-C motif chemokine 10
UniProt Synonym Protein Names
10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Interferon-inducible protein 10; Protein Mob-1; Small-inducible cytokine B10
UniProt Gene Name
Cxcl10
UniProt Synonym Gene Names
Inp10; Mob1; Scyb10; Gamma-IP10; IP-10
UniProt Entry Name
CXL10_RAT
NCBI Protein Information
C-X-C motif chemokine 10; gamma-IP10; protein Mob-1; small-inducible cytokine B10; interferon-inducible protein 10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; small inducible cytokine B subfamily (Cys-X-Cys) member 10; small inducible cytokine B subfamily (Cys-X-Cys), member 10

NCBI Summary for IP-10

induces DNA synthesis, cell proliferation, and cell migration in vascular smooth muscle cells; may play a role in vascular remodeling [RGD, Feb 2006]

UniProt Comments for IP-10

In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.

Research Articles on IP-10

1. CXCL10 may be a necessary algogenic molecule, especially in the development of Cancer-induced bone pain

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IP-10 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram

Diseases associated with anti-IP-10 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1119 publications with IP-10 and Inflammation
 Necrosis Antibodies  >650 publications with IP-10 and Necrosis
 Lung Diseases Antibodies  >319 publications with IP-10 and Lung Diseases
 Liver Diseases Antibodies  >220 publications with IP-10 and Liver Diseases
 Cardiovascular Diseases Antibodies  >161 publications with IP-10 and Cardiovascular Diseases
 Fibrosis Antibodies  >123 publications with IP-10 and Fibrosis
 Neoplasms, Experimental Antibodies  >110 publications with IP-10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >83 publications with IP-10 and Kidney Diseases
 Lung Injury Antibodies  >61 publications with IP-10 and Lung Injury
 Pneumonia Antibodies  >59 publications with IP-10 and Pneumonia

Organs/Tissues associated with anti-IP-10 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >258 publications with IP-10 and Liver
 Spleen Antibodies  >127 publications with IP-10 and Spleen
 Pituitary Gland Antibodies  >2 publications with IP-10 and Pituitary Gland
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