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sDLL-4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695472

Produced from sera of rabbits immunized with highly pure recombinant Human sDLL-4. Anti-Human sDLL-4 specific antibody was purified by affinity chromatography and then biotinylated. More details

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Product Overview

Product Name
DLL-4 (sDLL-4), Polyclonal Antibody
Full Product Name
Biotinylated Anti-hsDLL-4
Product Gene Name
anti-sDLL-4 antibody
Product Synonym Names
Biotinylated Anti-Human sDLL-4
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Biotin
Preparation and Storage
At -20 degree C
Molecular Weight
74,605 Da
OMIM
605185
3D Structure
ModBase 3D Structure for Q9NR61
Immunogen
Recombinant Human sDLL-4
Applications Tested/Suitable for anti-sDLL-4 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-sDLL-4 antibody
Direct Detection: To detect hsDLL-4 by direct ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hsDLL-4.

Sandwich ELISA: To detect hsDLL-4 by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with Polyclonal Anti-Human sDLL-4 as a capture antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hsDLL-4.

Western Blot: To detect hsDLL-4 by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 mug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hsDLL-4 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-sDLL-4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for sDLL-4 purchase

MBS695472 is an antibody targeting sDLL-4. Also known as Biotinylated Anti-hsDLL-4. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for sDLL-4. It may not necessarily be applicable to this product.

NCBI GI #
13431490
NCBI GeneID
54567
NCBI Accession #
Q9NR61.1
UniProt Primary Accession #
Q9NR61
UniProt Secondary Accession #
Q3KP23; Q9NQT9
UniProt Related Accession #
Q9NR61
NCBI Official Full Name
Delta-like protein 4
NCBI Official Synonym Full Names
delta-like 4 (Drosophila)
NCBI Official Symbol
DLL4
NCBI Official Synonym Symbols
hdelta2
UniProt Protein Name
Delta-like protein 4
UniProt Synonym Protein Names
Drosophila Delta homolog 4; Delta4
Protein Family
Homeobox protein
UniProt Gene Name
DLL4
UniProt Synonym Gene Names
Delta4
UniProt Entry Name
DLL4_HUMAN
NCBI Protein Information
delta-like protein 4; delta4; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; delta-like 4 protein; notch ligand delta-2; drosophila Delta homolog 4

NCBI Summary for sDLL-4

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]

UniProt Comments for sDLL-4

DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium.

Protein type: Membrane protein, integral; Cell development/differentiation

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: integral to membrane; plasma membrane

Molecular Function: calcium ion binding; Notch binding

Biological Process: patterning of blood vessels; negative regulation of cell proliferation; Notch signaling pathway; regulation of neurogenesis; visual perception; blood circulation; Notch receptor processing; blood vessel remodeling; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; signal transduction
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Research Articles on sDLL-4

1. findings suggest that ADAM10/Dll4 signaling is a major signaling pathway in ECs driving inflammatory events involved in inflammation and immune cell recruitment

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-sDLL-4 antibody

 Reference Product  PubMed Publications
 NOTCH1 antibody  >145 publications with sDLL-4 and NOTCH1
 NOTCH3 antibody  >32 publications with sDLL-4 and NOTCH3
 NOTCH2 antibody  >31 publications with sDLL-4 and NOTCH2
 HEY1 antibody  >28 publications with sDLL-4 and HEY1
 JAG2 antibody  >20 publications with sDLL-4 and JAG2
 JAG1 antibody  >20 publications with sDLL-4 and JAG1
 MIB1 antibody  >3 publications with sDLL-4 and MIB1
 ADAM10 antibody  >3 publications with sDLL-4 and ADAM10
 EFNB2 antibody  >2 publications with sDLL-4 and EFNB2

Pathways associated with anti-sDLL-4 antibody

 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram

Diseases associated with anti-sDLL-4 antibody

 Disease Name  Pubmed Publications
 Neovascularization, Pathologic Antibodies  >88 publications with sDLL-4 and Neovascularization, Pathologic
 Disease Models, Animal Antibodies  >32 publications with sDLL-4 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >23 publications with sDLL-4 and Neoplasms, Experimental
 Brain Diseases Antibodies  >19 publications with sDLL-4 and Brain Diseases
 Inflammation Antibodies  >16 publications with sDLL-4 and Inflammation
 Lung Neoplasms Antibodies  >13 publications with sDLL-4 and Lung Neoplasms
 Breast Neoplasms Antibodies  >12 publications with sDLL-4 and Breast Neoplasms
 Liver Diseases Antibodies  >8 publications with sDLL-4 and Liver Diseases
 Kidney Diseases Antibodies  >8 publications with sDLL-4 and Kidney Diseases
 Necrosis Antibodies  >8 publications with sDLL-4 and Necrosis

Organs/Tissues associated with anti-sDLL-4 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >263 publications with sDLL-4 and Vascular
 Muscle Antibodies  >33 publications with sDLL-4 and Muscle
 Brain Antibodies  >33 publications with sDLL-4 and Brain
 Lung Antibodies  >29 publications with sDLL-4 and Lung
 Eye Antibodies  >26 publications with sDLL-4 and Eye
 Heart Antibodies  >19 publications with sDLL-4 and Heart
 Intestine Antibodies  >12 publications with sDLL-4 and Intestine
 Placenta Antibodies  >12 publications with sDLL-4 and Placenta
 Kidney Antibodies  >9 publications with sDLL-4 and Kidney
 Ovary Antibodies  >8 publications with sDLL-4 and Ovary
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