Anti-NOV Polyclonal Antibody – Cat# MBS695486

NOV Antibody – Polyclonal

Name: NOV Antibody; Polyclonal; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS695486
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695486

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hNOV. Anti-Human NOV specific antibody was purified by affinity chromatography employing immobilized hNOV matrix. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

NOV, Polyclonal Antibody

Full Product Name

Anti-human NOV

Product Gene Name

anti-NOV antibody

Product Synonym Names

Anti-Human NOV

Clonality

Polyclonal

Species Reactivity

Human

Form/Format

Purified

Preparation and Storage

At -20 degree C

Molecular Weight

39,162 Da

OMIM

164958

3D Structure

ModBase 3D Structure for P48745

Immunogen

Recombinant Human NOV

Applications Tested/Suitable for anti-NOV antibody

Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

Application Notes for anti-NOV antibody

Immunohistochemistery: This antibody stained formalin-fixed, paraffin-embedded sections of human breast invasive ductal carcinoma. The recommended concentration is 0.25 ug/ml-0.50 ug/ml with an overnight incubation at 4 degree C. An HRP-labeled polymer detection system was used with a DAB chromogen. Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended.

Sandwich ELISA: To detect hNOV by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human NOV as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hNOV.

Western Blot: To detect hNOV by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hNOV is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-NOV antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NOV purchase

MBS695486 is an antibody targeting NOV. Also known as Anti-human NOV. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for NOV. It may not necessarily be applicable to this product.

NCBI GI #

1352515

NCBI GeneID

4856

NCBI Accession #

P48745.1

UniProt Primary Accession #

P48745

UniProt Secondary Accession #

Q6I9S3; Q96BY5; Q9UDE4; B2R5X7

UniProt Related Accession #

P48745

NCBI Official Full Name

Protein NOV homolog

NCBI Official Synonym Full Names

nephroblastoma overexpressed

NCBI Official Symbol

NOV

NCBI Official Synonym Symbols

CCN3; NOVh; IBP-9; IGFBP9; IGFBP-9

UniProt Protein Name

Protein NOV homolog

UniProt Synonym Protein Names

CCN family member 3; Insulin-like growth factor-binding protein 9; IBP-9; IGF-binding protein 9; IGFBP-9; Nephroblastoma-overexpressed gene protein homolog

Protein Family

Protein

UniProt Gene Name

NOV

UniProt Synonym Gene Names

CCN3; IGFBP9; NOVH; NovH; IBP-9; IGF-binding protein 9; IGFBP-9

UniProt Entry Name

NOV_HUMAN

NCBI Protein Information

protein NOV homolog; CCN family member 3; IGF-binding protein 9; insulin-like growth factor-binding protein 9; nephroblastoma-overexpressed gene protein homolog

NCBI Summary for NOV

The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]

UniProt Comments for NOV

NOV: Immediate-early protein likely to play a role in cell growth regulation. Belongs to the CCN family. Expression is down-regulated by WT1. Interacts with FBLN1.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q24.1

Cellular Component: proteinaceous extracellular matrix; cell soma; intracellular membrane-bound organelle; axon; dendrite

Molecular Function: integrin binding; heparin binding; insulin-like growth factor binding; growth factor activity

Biological Process: cell-cell signaling; regulation of gene expression; regulation of cell growth; signal transduction; cell adhesion

Research Articles on NOV

1. NOV may promote carcinogenesis via promotion of EMT and association with increased mTOR activity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NOV antibody

Reference Product	PubMed Publications
BMP2 antibody	>330 publications with NOV and BMP2
TEC antibody	>223 publications with NOV and TEC
MUSK antibody	>184 publications with NOV and MUSK
GJA1 antibody	>52 publications with NOV and GJA1
DDR1 antibody	>19 publications with NOV and DDR1
PLXNA1 antibody	>4 publications with NOV and PLXNA1

Pathways associated with anti-NOV antibody

Products by Pathway	Pathway Diagram
Delta-Notch Signaling Pathway antibodies	Delta-Notch Signaling Pathway Diagram

Diseases associated with anti-NOV antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>153151 publications with NOV and Nervous System Diseases
Cardiovascular Diseases Antibodies	>148162 publications with NOV and Cardiovascular Diseases
Vascular Diseases Antibodies	>106302 publications with NOV and Vascular Diseases
Heart Diseases Antibodies	>75472 publications with NOV and Heart Diseases
Brain Diseases Antibodies	>74101 publications with NOV and Brain Diseases
Carcinoma Antibodies	>55698 publications with NOV and Carcinoma
Inflammation Antibodies	>35441 publications with NOV and Inflammation
Kidney Diseases Antibodies	>33424 publications with NOV and Kidney Diseases
Hypertension Antibodies	>29661 publications with NOV and Hypertension
Adenocarcinoma Antibodies	>24488 publications with NOV and Adenocarcinoma

Organs/Tissues associated with anti-NOV antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>267840 publications with NOV and Blood
Brain Antibodies	>111603 publications with NOV and Brain
Heart Antibodies	>91516 publications with NOV and Heart
Vascular Antibodies	>80828 publications with NOV and Vascular
Bone Antibodies	>75148 publications with NOV and Bone
Liver Antibodies	>69436 publications with NOV and Liver
Muscle Antibodies	>67507 publications with NOV and Muscle
Kidney Antibodies	>52251 publications with NOV and Kidney
Lung Antibodies	>51694 publications with NOV and Lung
Skin Antibodies	>47625 publications with NOV and Skin