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CNTF Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695495

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant Rat CNTF. Anti-Rat CNTF specific antibody was purified by affinity chromatography employing immobilized Rat CNTF matrix. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CNTF, Polyclonal Antibody
Full Product Name
Anti-rat CNTF
Product Gene Name
anti-CNTF antibody
Product Synonym Names
Anti-Rat CNTF
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Form/Format
Purified
Preparation and Storage
At -20 degree C
Molecular Weight
22,854 Da
3D Structure
ModBase 3D Structure for P20294
Immunogen
Recombinant Rat CNTF
Applications Tested/Suitable for anti-CNTF antibody
Immunohistochemistery (IHC), Neutralization, ELISA (EIA), Western Blot (WB)
Application Notes for anti-CNTF antibody
Immunohistochemistery: This antibody stained colchicine injected rat brain (including the globus pallidus region) tissue. The primary antibody was incubated at 0.25 mg/ml overnight at 4 degree C. This was followed by a peroxidase conjugated secondary antibody and then a fluorescein Tyramide Signal Amplification (TSA™) reagent. Information and photo are courtesy of the Tissue Profiling group, SciLifeLab Stockholm.

Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of Rat CNTF (0.15 ng/ml), a concentration of 0.02-0.05 ug/ml of this antibody is required.

Sandwich ELISA: To detect Rat CNTF by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.5 - 2.0 mug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Rat CNTF as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat CNTF.

Western Blot: To detect Rat CNTF by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant Rat CNTF is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-CNTF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNTF purchase

MBS695495 is an antibody targeting CNTF. Also known as Anti-rat CNTF. Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CNTF. It may not necessarily be applicable to this product.

NCBI GI #
116587
NCBI GeneID
25707
NCBI Accession #
P20294.1
UniProt Primary Accession #
P20294
UniProt Related Accession #
P20294
NCBI Official Full Name
Ciliary neurotrophic factor
NCBI Official Synonym Full Names
ciliary neurotrophic factor
NCBI Official Symbol
Cntf
UniProt Protein Name
Ciliary neurotrophic factor
Protein Family
Ciliary neurotrophic factor
UniProt Gene Name
Cntf
UniProt Synonym Gene Names
CNTF
UniProt Entry Name
CNTF_RAT
NCBI Protein Information
ciliary neurotrophic factor; ciliary neurotropic factor

NCBI Summary for CNTF

a cytokine involved in neuronal degeneration and adipocyte gene expression [RGD, Feb 2006]

UniProt Comments for CNTF

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

Research Articles on CNTF

1. FGF-2 down-regulated the expression of endogenous CNTF.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CNTF antibody

 Reference Product  PubMed Publications
 Stat3 antibody  >209 publications with CNTF and Stat3
 Lifr antibody  >129 publications with CNTF and Lifr
 Gfap antibody  >114 publications with CNTF and Gfap
 Il6st antibody  >112 publications with CNTF and Il6st
 Socs3 antibody  >31 publications with CNTF and Socs3
 Pomc antibody  >16 publications with CNTF and Pomc
 Gap43 antibody  >8 publications with CNTF and Gap43
 Notch1 antibody  >7 publications with CNTF and Notch1
 Sox10 antibody  >4 publications with CNTF and Sox10

Pathways associated with anti-CNTF antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-CNTF antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >595 publications with CNTF and Nervous System Diseases
 Brain Diseases Antibodies  >300 publications with CNTF and Brain Diseases
 Disease Models, Animal Antibodies  >241 publications with CNTF and Disease Models, Animal
 Nerve Degeneration Antibodies  >196 publications with CNTF and Nerve Degeneration
 Inflammation Antibodies  >111 publications with CNTF and Inflammation
 Necrosis Antibodies  >91 publications with CNTF and Necrosis
 Weight Loss Antibodies  >73 publications with CNTF and Weight Loss
 Atrophy Antibodies  >69 publications with CNTF and Atrophy
 Movement Disorders Antibodies  >58 publications with CNTF and Movement Disorders
 Cognition Disorders Antibodies  >41 publications with CNTF and Cognition Disorders

Organs/Tissues associated with anti-CNTF antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1292 publications with CNTF and Brain
 Dorsal Root Ganglion Antibodies  >168 publications with CNTF and Dorsal Root Ganglion
 Kidney Antibodies  >40 publications with CNTF and Kidney
 Inner Ear Antibodies  >31 publications with CNTF and Inner Ear
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