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PTHrP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695512

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hPTHrP (human Parathyroid Hormone-related Protein). Anti-Human PTHrP specific antibody was purified by affinity chromatography employing immobilized hPTHrP matrix. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PTHrP, Polyclonal Antibody
Full Product Name
Anti-Human PTHrP
Product Gene Name
anti-PTHrP antibody
Product Synonym Names
Anti-Human PTHrP
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified
Preparation and Storage
At -20 degree C
Molecular Weight
23,942 Da
OMIM
gene 613382
3D Structure
ModBase 3D Structure for P12272
Immunogen
Recombinant Human PTHrP
Applications Tested/Suitable for anti-PTHrP antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-PTHrP antibody
Sandwich ELISA: To detect hPTHrP by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.5 - 2.0 mug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human PTHrP as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hPTHrP.

Western Blot: To detect hPTHrP by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 mug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hPTHrP is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-PTHrP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTHrP purchase

MBS695512 is an antibody targeting PTHrP. Also known as Anti-Human PTHrP. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTHrP. It may not necessarily be applicable to this product.

NCBI GI #
131542
NCBI GeneID
5744
NCBI Accession #
P12272.1
UniProt Primary Accession #
P12272
UniProt Secondary Accession #
Q15251; Q6FH74
UniProt Related Accession #
P12272
NCBI Official Full Name
Parathyroid hormone-related protein
NCBI Official Synonym Full Names
parathyroid hormone-like hormone
NCBI Official Symbol
PTHLH
NCBI Official Synonym Symbols
HHM; PLP; BDE2; PTHR; PTHRP
UniProt Protein Name
Parathyroid hormone-related protein
UniProt Synonym Protein Names
Parathyroid hormone-like protein; PLP
Protein Family
Parathyroid hormone/parathyroid hormone-related peptide receptor
UniProt Gene Name
PTHLH
UniProt Synonym Gene Names
PTHRP; PTH-rP; PTHrP; PLP
UniProt Entry Name
PTHR_HUMAN
NCBI Protein Information
parathyroid hormone-related protein; PTH-rP; osteostatin; PTH-related protein; parathyroid hormone-like related protein; parathyroid hormone-like hormone preproprotein

UniProt Comments for PTHrP

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTHrP antibody

 Reference Product  PubMed Publications
 PTH antibody  >446 publications with PTHrP and PTH
 IHH antibody  >21 publications with PTHrP and IHH
 PTH1R antibody  >16 publications with PTHrP and PTH1R
 PTH2R antibody  >4 publications with PTHrP and PTH2R
 IL6 antibody  >3 publications with PTHrP and IL6
 PTCH1 antibody  >1 publications with PTHrP and PTCH1

Pathways associated with anti-PTHrP antibody

 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Signaling Events Mediated By The Hedgehog Family Pathway antibodies  Signaling Events Mediated By The Hedgehog Family Pathway Diagram

Diseases associated with anti-PTHrP antibody

 Disease Name  Pubmed Publications
 Hypercalcemia Antibodies  >613 publications with PTHrP and Hypercalcemia
 Bone Resorption Antibodies  >139 publications with PTHrP and Bone Resorption
 Breast Neoplasms Antibodies  >125 publications with PTHrP and Breast Neoplasms
 Lung Neoplasms Antibodies  >104 publications with PTHrP and Lung Neoplasms
 Lung Diseases Antibodies  >89 publications with PTHrP and Lung Diseases
 Kidney Diseases Antibodies  >67 publications with PTHrP and Kidney Diseases
 Necrosis Antibodies  >48 publications with PTHrP and Necrosis
 Osteolysis Antibodies  >42 publications with PTHrP and Osteolysis
 Disease Models, Animal Antibodies  >39 publications with PTHrP and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >39 publications with PTHrP and Neoplasms, Experimental

Organs/Tissues associated with anti-PTHrP antibody

 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >1210 publications with PTHrP and Parathyroid
 Kidney Antibodies  >144 publications with PTHrP and Kidney
 Lung Antibodies  >130 publications with PTHrP and Lung
 Skin Antibodies  >72 publications with PTHrP and Skin
 Embryonic Tissue Antibodies  >61 publications with PTHrP and Embryonic Tissue
 Prostate Antibodies  >43 publications with PTHrP and Prostate
 Uterus Antibodies  >32 publications with PTHrP and Uterus
 Mammary Gland Antibodies  >32 publications with PTHrP and Mammary Gland
 Brain Antibodies  >28 publications with PTHrP and Brain
 Pancreas Antibodies  >25 publications with PTHrP and Pancreas
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