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GRO / MGSA (GRO/MGSA) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695521

Produced from sera of rabbits pre-immunized with highly pure recombinant Human GRO/MGSA. Anti-Human GRO/MGSA specific antibody was purified by affinity chromatography employing immobilized Human GRO/MGSA matrix. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
GRO / MGSA (GRO/MGSA), Polyclonal Antibody
Full Product Name
Anti-human GRO / MGSA
Product Gene Name
anti-GRO/MGSA antibody
Product Synonym Names
Anti-Human GRO/MGSA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified
Preparation and Storage
At -20 degree C
Molecular Weight
11,301 Da
OMIM
155730
3D Structure
ModBase 3D Structure for P09341
Immunogen
Recombinant Human GRO/MGSA
Applications Tested/Suitable for anti-GRO/MGSA antibody
Immunohistochemistry (IHC) Formalin/Paraffin, Neutralization, ELISA (EIA), Western Blot (WB)
Application Notes for anti-GRO/MGSA antibody
Immunohistochemistery: This antibody stained formalin-fixed, paraffin-embedded sections of human colon/rectum adenocarcinoma. The recommended concentration is 0.125 mug/ml-0.150 mug/ml with an overnight incubation at 4 degree C. An HRP-labeled polymer detection system was used with a DAB chromogen. Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended.

Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of Human GRO/MGSA (100 ng/ml), a concentration of 1.5-3.0 ug/ml of this antibody is required.

Sandwich ELISA: To detect Human GRO/MGSA by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.5 - 2.0 mug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human GRO/MGSA as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human GRO/MGSA.

Western Blot: To detect Human GRO/MGSA by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 ug/ml. When used in conjunction with compatible secondary reagents, the detection limit for recombinant Human GRO/MGSA is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-GRO/MGSA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRO/MGSA purchase

MBS695521 is an antibody targeting GRO/MGSA. Also known as Anti-human GRO / MGSA. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GRO/MGSA. It may not necessarily be applicable to this product.

NCBI GI #
121622
NCBI GeneID
2919
NCBI Accession #
P09341.1
UniProt Primary Accession #
P09341
UniProt Secondary Accession #
Q9UCR7
UniProt Related Accession #
P09341
NCBI Official Full Name
Growth-regulated alpha protein
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
NCBI Official Symbol
CXCL1
NCBI Official Synonym Symbols
FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a
UniProt Protein Name
Growth-regulated alpha protein
UniProt Synonym Protein Names
C-X-C motif chemokine 1; GRO-alpha(1-73); Melanoma growth stimulatory activity; MGSA; Neutrophil-activating protein 3; NAP-3
Protein Family
C-X-C chemokine receptor
UniProt Gene Name
CXCL1
UniProt Synonym Gene Names
GRO; GRO1; GROA; MGSA; SCYB1; MGSA; NAP-3
UniProt Entry Name
GROA_HUMAN
NCBI Protein Information
growth-regulated alpha protein; MGSA alpha; GRO-alpha(1-73); C-X-C motif chemokine 1; fibroblast secretory protein; neutrophil-activating protein 3; melanoma growth stimulatory activity alpha; GRO1 oncogene (melanoma growth-stimulating activity); GRO1 oncogene (melanoma growth stimulating activity, alpha)

NCBI Summary for GRO/MGSA

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]
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UniProt Comments for GRO/MGSA

CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; chemokine activity; CXCR chemokine receptor binding; enzyme activator activity; receptor binding

Biological Process: positive regulation of catalytic activity; cell proliferation; G-protein coupled receptor protein signaling pathway; nervous system development; negative regulation of cell proliferation; positive regulation of leukocyte chemotaxis; immune response; response to lipopolysaccharide; inflammatory response; chemotaxis; actin cytoskeleton organization and biogenesis; signal transduction
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Research Articles on GRO/MGSA

1. The present study showed that nasal fibroblasts can produce GRO-alpha and IL-8, and their production is remarkably enhanced by IL-17 stimulation, thereby clarifying the mechanism of the IL-17 mediated neutrophil infiltration in nasal polyps.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRO/MGSA antibody

 Reference Product  PubMed Publications
 CXCL2 antibody  >557 publications with GRO/MGSA and CXCL2
 CXCR2 antibody  >317 publications with GRO/MGSA and CXCR2
 CCL5 antibody  >249 publications with GRO/MGSA and CCL5
 CXCL3 antibody  >98 publications with GRO/MGSA and CXCL3
 CXCR1 antibody  >97 publications with GRO/MGSA and CXCR1
 CCL20 antibody  >96 publications with GRO/MGSA and CCL20
 CXCL6 antibody  >75 publications with GRO/MGSA and CXCL6
 IL6 antibody  >67 publications with GRO/MGSA and IL6
 CXCL11 antibody  >32 publications with GRO/MGSA and CXCL11
 DARC antibody  >12 publications with GRO/MGSA and DARC

Pathways associated with anti-GRO/MGSA antibody

 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram

Diseases associated with anti-GRO/MGSA antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1146 publications with GRO/MGSA and Inflammation
 Necrosis Antibodies  >557 publications with GRO/MGSA and Necrosis
 Disease Models, Animal Antibodies  >414 publications with GRO/MGSA and Disease Models, Animal
 Lung Diseases Antibodies  >325 publications with GRO/MGSA and Lung Diseases
 Cardiovascular Diseases Antibodies  >190 publications with GRO/MGSA and Cardiovascular Diseases
 Lung Injury Antibodies  >170 publications with GRO/MGSA and Lung Injury
 Pneumonia Antibodies  >113 publications with GRO/MGSA and Pneumonia
 Acute Lung Injury Antibodies  >97 publications with GRO/MGSA and Acute Lung Injury
 Reperfusion Injury Antibodies  >97 publications with GRO/MGSA and Reperfusion Injury
 Wounds and Injuries Antibodies  >95 publications with GRO/MGSA and Wounds and Injuries

Organs/Tissues associated with anti-GRO/MGSA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1237 publications with GRO/MGSA and Blood
 Lung Antibodies  >496 publications with GRO/MGSA and Lung
 Vascular Antibodies  >364 publications with GRO/MGSA and Vascular
 Liver Antibodies  >183 publications with GRO/MGSA and Liver
 Skin Antibodies  >174 publications with GRO/MGSA and Skin
 Intestine Antibodies  >157 publications with GRO/MGSA and Intestine
 Heart Antibodies  >82 publications with GRO/MGSA and Heart
 Connective Tissue Antibodies  >62 publications with GRO/MGSA and Connective Tissue
 Uterus Antibodies  >24 publications with GRO/MGSA and Uterus
 Ascites Antibodies  >5 publications with GRO/MGSA and Ascites
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