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Neurturin (NRTN) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695531

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hNeurturin (human Neurturin). Anti-Human Neurturin specific antibody was purified by affinity chromatography and then biotinylated. More details

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Product Overview

Product Name
Neurturin (NRTN), Polyclonal Antibody
Full Product Name
Biotinylated Anti-hNeurturin
Product Gene Name
anti-NRTN antibody
Product Synonym Names
Biotinylated Anti-Human Neurturin
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Biotin
Preparation and Storage
At -20 degree C
Molecular Weight
22,405 Da
OMIM
602018
3D Structure
ModBase 3D Structure for Q99748
Immunogen
Recombinant Human Neurturin
Applications Tested/Suitable for anti-NRTN antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-NRTN antibody
Direct Detection: To detect hNeurturin by direct ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hNeurturin.

Sandwich ELISA: To detect hNeurturin by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with Polyclonal Anti-Human Neurturin as a capture antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hNeurturin.

Western Blot: To detect hNeurturin by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 mug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hNeurturin is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-NRTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NRTN purchase

MBS695531 is an antibody targeting NRTN. Also known as Biotinylated Anti-hNeurturin. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NRTN. It may not necessarily be applicable to this product.

NCBI GI #
2501180
NCBI GeneID
4902
NCBI Accession #
Q99748.1
UniProt Primary Accession #
Q99748
UniProt Secondary Accession #
B2RPE8
UniProt Related Accession #
Q99748
NCBI Official Full Name
Neurturin
NCBI Official Synonym Full Names
neurturin
NCBI Official Symbol
NRTN
NCBI Official Synonym Symbols
NTN
UniProt Protein Name
Neurturin
Protein Family
Neurturin
UniProt Gene Name
NRTN
UniProt Entry Name
NRTN_HUMAN
NCBI Protein Information
neurturin; prepro-neurturin

NCBI Summary for NRTN

Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Jul 2008]

UniProt Comments for NRTN

NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: axon; extracellular region

Molecular Function: growth factor activity; receptor binding

Biological Process: axon guidance; nervous system development; MAPKKK cascade; nerve development; neural crest cell migration; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Hirschsprung Disease, Susceptibility To, 1
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Research Articles on NRTN

1. In the cochlea, NTN immunostaining was found in the supporting cells of organ of Corti, including Deiters' cells, Hensen cells as well as Claudius' cells. In the spiral ganglia, NTN was seen in both the cell bodies and the nerve fibers of neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NRTN antibody

 Reference Product  PubMed Publications
 GDNF antibody  >145 publications with NRTN and GDNF
 RET antibody  >108 publications with NRTN and RET
 GFRA2 antibody  >43 publications with NRTN and GFRA2
 GFRA1 antibody  >36 publications with NRTN and GFRA1
 ARTN antibody  >22 publications with NRTN and ARTN
 PSPN antibody  >11 publications with NRTN and PSPN
 GFRA3 antibody  >7 publications with NRTN and GFRA3
 NCAM1 antibody  >4 publications with NRTN and NCAM1

Pathways associated with anti-NRTN antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
 NCAM1 Interactions Pathway antibodies  NCAM1 Interactions Pathway Diagram

Diseases associated with anti-NRTN antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >29 publications with NRTN and Nervous System Diseases
 Nerve Degeneration Antibodies  >23 publications with NRTN and Nerve Degeneration
 Disease Models, Animal Antibodies  >18 publications with NRTN and Disease Models, Animal
 Congenital Abnormalities Antibodies  >8 publications with NRTN and Congenital Abnormalities
 Hirschsprung Disease Antibodies  >8 publications with NRTN and Hirschsprung Disease
 Inflammation Antibodies  >5 publications with NRTN and Inflammation
 Weight Loss Antibodies  >3 publications with NRTN and Weight Loss
 Necrosis Antibodies  >2 publications with NRTN and Necrosis
 Fetal Death Antibodies  >2 publications with NRTN and Fetal Death
 Hypertrophy Antibodies  >2 publications with NRTN and Hypertrophy

Organs/Tissues associated with anti-NRTN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >67 publications with NRTN and Brain
 Eye Antibodies  >17 publications with NRTN and Eye
 Muscle Antibodies  >14 publications with NRTN and Muscle
 Intestine Antibodies  >14 publications with NRTN and Intestine
 Pancreas Antibodies  >3 publications with NRTN and Pancreas
 Lung Antibodies  >1 publications with NRTN and Lung
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