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GRO-beta Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695549

Produced from sera of rabbits pre-immunized with highly pure recombinant Human GRO-beta. Anti-Human GRO-beta specific antibody was purified by affinity chromatography and then biotinylated. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GRObeta (GRO-beta), Polyclonal Antibody
Full Product Name
Biotinylated Anti-hGRObeta
Product Gene Name
anti-GRO-beta antibody
Product Synonym Names
Biotinylated Anti-Human GRO-beta
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Biotin
Preparation and Storage
At -20 degree C
Molecular Weight
11,389 Da
OMIM
139110
3D Structure
ModBase 3D Structure for P19875
Immunogen
Recombinant Human GRO-beta
Applications Tested/Suitable for anti-GRO-beta antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-GRO-beta antibody
Direct Detection: To detect Human GRO-beta by direct ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human GRO-beta.

Sandwich ELISA: To detect Human GRO-beta by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with Polyclonal Anti-Human GRO-beta as a capture antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human GRO-beta.

Western Blot: To detect Human GRO-beta by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 mug/ml. When used in conjunction with compatible secondary reagents, the detection limit for recombinant Human GRO-beta is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-GRO-beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRO-beta purchase

MBS695549 is an antibody targeting GRO-beta. Also known as Biotinylated Anti-hGRObeta. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GRO-beta. It may not necessarily be applicable to this product.

NCBI GI #
127085
NCBI GeneID
2920
NCBI Accession #
P19875.1
UniProt Primary Accession #
P19875
UniProt Secondary Accession #
Q6FGD6; Q9UPB8
UniProt Related Accession #
P19875
NCBI Official Full Name
C-X-C motif chemokine 2
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 2
NCBI Official Symbol
CXCL2
NCBI Official Synonym Symbols
GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a
UniProt Protein Name
C-X-C motif chemokine 2
UniProt Synonym Protein Names
Growth-regulated protein beta; Gro-beta; Macrophage inflammatory protein 2-alpha; MIP2-alpha
UniProt Gene Name
CXCL2
UniProt Synonym Gene Names
GRO2; GROB; MIP2A; SCYB2; Gro-beta; MIP2-alpha; HSF
UniProt Entry Name
CXCL2_HUMAN
NCBI Protein Information
C-X-C motif chemokine 2; gro-beta; MGSA beta; MIP2-alpha; GRO2 oncogene; growth-regulated protein beta; macrophage inflammatory protein 2-alpha; melanoma growth stimulatory activity beta

NCBI Summary for GRO-beta

This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
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UniProt Comments for GRO-beta

CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; response to molecule of bacterial origin; response to lipopolysaccharide; immune response; positive regulation of leukocyte chemotaxis; inflammatory response; chemotaxis; regulation of cell proliferation
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Research Articles on GRO-beta

1. CXCL2 has antimicrobial activity against E. coli and S. aureus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRO-beta antibody

 Reference Product  PubMed Publications
 CXCL1 antibody  >557 publications with GRO-beta and CXCL1
 CCL4 antibody  >185 publications with GRO-beta and CCL4
 CXCR2 antibody  >151 publications with GRO-beta and CXCR2
 CCL5 antibody  >122 publications with GRO-beta and CCL5
 CXCL3 antibody  >99 publications with GRO-beta and CXCL3
 CCL20 antibody  >76 publications with GRO-beta and CCL20
 CCR1 antibody  >25 publications with GRO-beta and CCR1
 CXCR1 antibody  >25 publications with GRO-beta and CXCR1
 CCR5 antibody  >22 publications with GRO-beta and CCR5
 CCL19 antibody  >7 publications with GRO-beta and CCL19

Pathways associated with anti-GRO-beta antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with anti-GRO-beta antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1008 publications with GRO-beta and Inflammation
 Necrosis Antibodies  >643 publications with GRO-beta and Necrosis
 Lung Diseases Antibodies  >383 publications with GRO-beta and Lung Diseases
 Disease Models, Animal Antibodies  >355 publications with GRO-beta and Disease Models, Animal
 Lung Injury Antibodies  >259 publications with GRO-beta and Lung Injury
 Pneumonia Antibodies  >173 publications with GRO-beta and Pneumonia
 Reperfusion Injury Antibodies  >115 publications with GRO-beta and Reperfusion Injury
 Wounds and Injuries Antibodies  >95 publications with GRO-beta and Wounds and Injuries
 Edema Antibodies  >92 publications with GRO-beta and Edema
 Skin Diseases Antibodies  >81 publications with GRO-beta and Skin Diseases

Organs/Tissues associated with anti-GRO-beta antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1061 publications with GRO-beta and Blood
 Lung Antibodies  >624 publications with GRO-beta and Lung
 Liver Antibodies  >202 publications with GRO-beta and Liver
 Bone Antibodies  >166 publications with GRO-beta and Bone
 Bone Marrow Antibodies  >137 publications with GRO-beta and Bone Marrow
 Brain Antibodies  >119 publications with GRO-beta and Brain
 Intestine Antibodies  >113 publications with GRO-beta and Intestine
 Kidney Antibodies  >98 publications with GRO-beta and Kidney
 Eye Antibodies  >57 publications with GRO-beta and Eye
 Pancreas Antibodies  >42 publications with GRO-beta and Pancreas
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