Human GM-CSF Active Protein – Cat# MBS695614

GM-CSF Human Active Protein

Name: GM-CSF Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS695614
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695614

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells,… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GM-CSF, Active Protein

Full Product Name

Animal Free Human GM-CSF

Product Gene Name

GM-CSF active protein

Product Synonym Names

Animal-Free Recombinant Human GM-CSF

Sequence

MAPARSPSP STQPWEHVN AIQEARRLL NLSRDTAAE MNETVEVIS EMFDLQEPT CLQTRLELY KQGLRGSLT KLKGPLTMM ASHYKQHCP PTPETSCAT QIITFESFK ENLKDFLLV IPFDCWEPV QE

Host

E Coli

Species Reactivity

Species Reactivity: Animal Free Human GM-CSF

Purity/Purification

Above 98% as determined by SDS-PAGE Analysis.

Molecular Weight

16,295 Da

OMIM

138960

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <= 0.1 ng/ml, corresponding to a specific activity of >= 1 x 107 units/mg.

Cell Type

Monocytes and Macrophages, Treg cells, Stem Cells, Endothelial Cells

Product Categories/Family for GM-CSF active protein

Innate Immunity; Stem Cell Research; Cancer; Inflammation; Proliferation and Cell Cycle

Other Notes

Small volumes of GM-CSF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GM-CSF purchase

MBS695614 is an active protein targeting GM-CSF. Also known as Animal Free Human GM-CSF. Reactive in Species Reactivity: Animal Free Human GM-CSF. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GM-CSF. It may not necessarily be applicable to this product.

NCBI GI #

183364

NCBI GeneID

1437

NCBI Accession #

AAA52578.1

UniProt Secondary Accession #

Q14CE8; Q2VPI8; Q8NFI6

UniProt Related Accession #

P04141

NCBI Official Full Name

GM-CSF

NCBI Official Synonym Full Names

colony stimulating factor 2 (granulocyte-macrophage)

NCBI Official Symbol

CSF2

NCBI Official Synonym Symbols

GMCSF

UniProt Protein Name

Granulocyte-macrophage colony-stimulating factor

UniProt Synonym Protein Names

Colony-stimulating factor; CSF; Molgramostin; Sargramostim

Protein Family

Granulocyte colony-stimulating factor receptor

UniProt Gene Name

CSF2

UniProt Synonym Gene Names

GMCSF; GM-CSF; CSF

UniProt Entry Name

CSF2_HUMAN

NCBI Protein Information

granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim

NCBI Summary for GM-CSF

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]

UniProt Comments for GM-CSF

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity

Biological Process: negative regulation of cytolysis; epithelial fluid transport; macrophage activation; embryonic placenta development; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; immune response; myeloid dendritic cell differentiation; positive regulation of DNA replication

Research Articles on GM-CSF

1. The association of GM-CSF expression with systemic inflammation highlights the potential role of Th17-related cytokines in the pathology of juvenile idiopathic arthritis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GM-CSF active protein

Reference Product	PubMed Publications
IL4 active protein	>17 publications with GM-CSF and IL4
IL3 active protein	>14 publications with GM-CSF and IL3
IL5 active protein	>10 publications with GM-CSF and IL5
CSF2RB active protein	>10 publications with GM-CSF and CSF2RB
CSF2RA active protein	>5 publications with GM-CSF and CSF2RA
STAT3 active protein	>3 publications with GM-CSF and STAT3
JAK2 active protein	>2 publications with GM-CSF and JAK2
FOS active protein	>2 publications with GM-CSF and FOS
SDC2 active protein	>1 publications with GM-CSF and SDC2

Pathways associated with GM-CSF active protein

Products by Pathway	Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies	Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
Calcium Signaling In The CD4+ TCR Pathway antibodies	Calcium Signaling In The CD4+ TCR Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram

Diseases associated with GM-CSF active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>38 publications with GM-CSF and Inflammation
Necrosis Antibodies	>25 publications with GM-CSF and Necrosis
Lung Diseases Antibodies	>9 publications with GM-CSF and Lung Diseases
Breast Neoplasms Antibodies	>6 publications with GM-CSF and Breast Neoplasms
Carcinoma Antibodies	>3 publications with GM-CSF and Carcinoma
Leukemia, Myeloid, Acute Antibodies	>3 publications with GM-CSF and Leukemia, Myeloid, Acute
Cardiovascular Diseases Antibodies	>3 publications with GM-CSF and Cardiovascular Diseases
Neoplasms, Experimental Antibodies	>3 publications with GM-CSF and Neoplasms, Experimental
Lung Neoplasms Antibodies	>3 publications with GM-CSF and Lung Neoplasms
Arthritis, Rheumatoid Antibodies	>2 publications with GM-CSF and Arthritis, Rheumatoid

Organs/Tissues associated with GM-CSF active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>41 publications with GM-CSF and Blood
Bone Antibodies	>15 publications with GM-CSF and Bone
Lung Antibodies	>11 publications with GM-CSF and Lung
Intestine Antibodies	>2 publications with GM-CSF and Intestine