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TGF-beta3 Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695652

The three mammalian isoforms of TGF-beta, TGF-beta1, beta2, beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as… More details

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Product Overview

Product Name
TGF-beta3, Active Protein
Full Product Name
Animal Free Human TGF-beta3
Product Gene Name
TGF-beta3 active protein
Product Synonym Names
Animal-Free Recombinant Human TGF-beta3 (E Coli derived)
Sequence
ALDTNYCFR NLEENCCVR PLYIDFRQD LGWKWVHEP KGYYANFCS GPCPYLRSA DTTHSTVLG LYNTLNPEA SASPCCVPQ DLEPLTILY YVGRTPKVE QLSNMVVKS CKCS
Host
E Coli
Species Reactivity
Species Reactivity: Animal Free Human TGF-beta3
Cross Reactivity: Cow, Dog, Mouse, Pig, Rat
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Molecular Weight
35,708 Da
OMIM
gene 615582
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
The ED50 was determined by TGF-beta3's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is <= 0.05 ng/ml, corresponding to a specific activity of >=2 x 10<

Product Categories/Family for TGF-beta3 active protein

Innate Immunity; Adaptive Immunity; Stem Cell Research; Apoptosis; Cancer; Angiogenesis; Inflammation; Proliferation and Cell Cycle

Other Notes

Small volumes of TGF-beta3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGF-beta3 purchase

MBS695652 is an active protein targeting TGF-beta3. Also known as Animal Free Human TGF-beta3. Reactive in Species Reactivity: Animal Free Human TGF-beta3
Cross Reactivity: Cow, Dog, Mouse, Pig, Rat. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TGF-beta3. It may not necessarily be applicable to this product.

NCBI GI #
4507465
NCBI GeneID
7043
NCBI Accession #
NP_003230.1
UniProt Secondary Accession #
Q8WV88
UniProt Related Accession #
P10600
GenBank Nucleotide #
NM_003239.3
NCBI Official Full Name
transforming growth factor beta-3 preproprotein
NCBI Official Synonym Full Names
transforming growth factor, beta 3
NCBI Official Symbol
TGFB3
NCBI Official Synonym Symbols
ARVD; RNHF; ARVD1; TGF-beta3
UniProt Protein Name
Transforming growth factor beta-3
UniProt Gene Name
TGFB3
UniProt Synonym Gene Names
TGF-beta-3; LAP
UniProt Entry Name
TGFB3_HUMAN
NCBI Protein Information
transforming growth factor beta-3; TGF-beta-3; prepro-transforming growth factor beta-3

NCBI Summary for TGF-beta3

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

UniProt Comments for TGF-beta3

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.

Protein type: Motility/polarity/chemotaxis; Ligand, receptor tyrosine kinase; Secreted, signal peptide; Secreted; Cell development/differentiation

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; plasma membrane; extracellular region; nucleus

Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; transforming growth factor beta binding; punt binding; cytokine activity

Biological Process: extracellular matrix organization and biogenesis; activation of MAPK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; SMAD protein nuclear translocation; female pregnancy; palate development; odontogenesis; regulation of apoptosis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; uterine wall breakdown; positive regulation of filopodium formation; intercellular junction assembly and maintenance; platelet activation; in utero embryonic development; positive regulation of bone mineralization; regulation of cell proliferation; gut development; positive regulation of protein secretion; negative regulation of DNA replication; response to estrogen stimulus; regulation of MAPKKK cascade; positive regulation of cell division; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway; response to progesterone stimulus; alveolus development; positive regulation of DNA replication

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome
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Research Articles on TGF-beta3

1. These results unequivocally demonstrate that human TGF-beta3 elicits bone induction by up-regulation of endogenous BMP-2 and is blocked by hNoggin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TGF-beta3 active protein

 Reference Product  PubMed Publications
 TGFB2 active protein  >571 publications with TGF-beta3 and TGFB2
 EGF active protein  >21 publications with TGF-beta3 and EGF
 SERPINE1 active protein  >16 publications with TGF-beta3 and SERPINE1
 TGFBR2 active protein  >10 publications with TGF-beta3 and TGFBR2
 TGFBR1 active protein  >9 publications with TGF-beta3 and TGFBR1
 SMAD5 active protein  >2 publications with TGF-beta3 and SMAD5
 TIMP1 active protein  >1 publications with TGF-beta3 and TIMP1
 ACVRL1 active protein  >1 publications with TGF-beta3 and ACVRL1
 FN1 active protein  >1 publications with TGF-beta3 and FN1

Pathways associated with TGF-beta3 active protein

 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram

Diseases associated with TGF-beta3 active protein

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >190 publications with TGF-beta3 and Fibrosis
 Cleft Palate Antibodies  >106 publications with TGF-beta3 and Cleft Palate
 Disease Models, Animal Antibodies  >104 publications with TGF-beta3 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >87 publications with TGF-beta3 and Cardiovascular Diseases
 Inflammation Antibodies  >81 publications with TGF-beta3 and Inflammation
 Necrosis Antibodies  >64 publications with TGF-beta3 and Necrosis
 Heart Diseases Antibodies  >53 publications with TGF-beta3 and Heart Diseases
 Hypertrophy Antibodies  >39 publications with TGF-beta3 and Hypertrophy
 Breast Neoplasms Antibodies  >38 publications with TGF-beta3 and Breast Neoplasms
 Lung Diseases Antibodies  >36 publications with TGF-beta3 and Lung Diseases

Organs/Tissues associated with TGF-beta3 active protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >357 publications with TGF-beta3 and Bone
 Connective Tissue Antibodies  >247 publications with TGF-beta3 and Connective Tissue
 Embryonic Tissue Antibodies  >143 publications with TGF-beta3 and Embryonic Tissue
 Bone Marrow Antibodies  >128 publications with TGF-beta3 and Bone Marrow
 Mouth Antibodies  >120 publications with TGF-beta3 and Mouth
 Heart Antibodies  >80 publications with TGF-beta3 and Heart
 Lung Antibodies  >76 publications with TGF-beta3 and Lung
 Eye Antibodies  >67 publications with TGF-beta3 and Eye
 Brain Antibodies  >65 publications with TGF-beta3 and Brain
 Liver Antibodies  >51 publications with TGF-beta3 and Liver
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