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PECAM-1 Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695725

PECAM is transmembrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. It is highly expressed at endothelial cell junctions, and also expressed in platelets and in most leukocyte sub-types. The primary function of PECAM-1 is the… More details

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Product Overview

Product Name
PECAM-1, Active Protein
Full Product Name
Human PECAM-1
Product Gene Name
PECAM-1 active protein
Product Synonym Names
Recombinant Human PECAM-1
Sequence
ENSFTINSV DMKSLPDWT VQNGKNLTL QCFADVSTT SHVKPQHQM LFYKDDVLF YNISSMKST ESYFIPEVR IYDSGTYKC TVIVNNKEK TTAEYQLLV EGVPSPRVT LDKKEAIQG GIVRVNCSV PEEKAPIHF TIEKLELNE KMVKLKREK NSRDQNFVI LEFPVEEQD RVLSFRCQA RIISGIHMQ TSESTKSEL VTVTESFST PKFHISPTG MIMEGAQLH IKCTIQVTH LAQEFPEII IQKDKAIVA HNRHGNKAV YSVMAMVEH SGNYTCKVE SSRISKVSS IVVNITELF SKPELESSF THLDQGERL NLSCSIPGA PPANFTIQK EDTIVSQTQ DFTKIASKS DSGTYICTA GIDKVVKKS NTVQIVVCE MLSQPRISY DAQFEVIKG QTIEVRCES ISGTLPISY QLLKTSKVL ENSTKNSND PAVFKDNPT EDVEYQCVA DNCHSHAKM LSEVLRVKV IAPVDEVQI SILSSKVVE SGEDIVLQC AVNEGSGPI TYKFYREKE GKPFYQMTS NATQAFWTK QKASKEQEG EYYCTAFNR ANHASSVPR SKILTVRVI LAPWK
Host
HEK293 cells
Species Reactivity
Species Reactivity: Human
Purity/Purification
Above 97% as determined by SDS-PAGE Analysis.
Preparation and Storage
At -20 degree C
Molecular Weight
81,378 Da
OMIM
173445
3D Structure
ModBase 3D Structure for P16284
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Determined by its ability to support the adhesion of activated Jurkat cells. The expected ED50 for this effect is 1.0 -1.5 mug/ml.
Cell Type
Endothelial Cells

Product Categories/Family for PECAM-1 active protein

Inflammation

Other Notes

Small volumes of PECAM-1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PECAM-1 purchase

MBS695725 is an active protein targeting PECAM-1. Also known as Human PECAM-1. Reactive in Species Reactivity: Human. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for PECAM-1. It may not necessarily be applicable to this product.

NCBI GI #
129747
NCBI GeneID
5175
NCBI Accession #
P16284.1
UniProt Primary Accession #
P16284
UniProt Secondary Accession #
Q6LDA9; Q8TBH1; Q96RF5; Q96RF6; Q9NP65; Q9NPB7; Q9NPG9; Q9NQS9; Q9NQT0; A8K3S7; D3DU31
UniProt Related Accession #
P16284
NCBI Official Full Name
Platelet endothelial cell adhesion molecule
NCBI Official Synonym Full Names
platelet/endothelial cell adhesion molecule 1
NCBI Official Symbol
PECAM1
NCBI Official Synonym Symbols
CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
UniProt Protein Name
Platelet endothelial cell adhesion molecule
UniProt Synonym Protein Names
EndoCAM; GPIIA'; PECA1; CD_antigen: CD31
Protein Family
Platelet endothelial cell adhesion molecule
UniProt Gene Name
PECAM1
UniProt Synonym Gene Names
PECAM-1
UniProt Entry Name
PECA1_HUMAN
NCBI Protein Information
platelet endothelial cell adhesion molecule; CD31 antigen

NCBI Summary for PECAM-1

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
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UniProt Comments for PECAM-1

PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: extracellular space; platelet alpha granule membrane; integral to membrane; plasma membrane; cell junction

Molecular Function: protein binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; diapedesis; cell recognition; cell adhesion; signal transduction; blood coagulation; leukocyte migration; phagocytosis
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Research Articles on PECAM-1

1. S. pneumoniae physically binds to PECAM-1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PECAM-1 active protein

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram

Diseases associated with PECAM-1 active protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >624 publications with PECAM-1 and Cardiovascular Diseases
 Inflammation Antibodies  >495 publications with PECAM-1 and Inflammation
 Necrosis Antibodies  >401 publications with PECAM-1 and Necrosis
 Neoplasms, Experimental Antibodies  >261 publications with PECAM-1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >239 publications with PECAM-1 and Lung Diseases
 Heart Diseases Antibodies  >229 publications with PECAM-1 and Heart Diseases
 Breast Neoplasms Antibodies  >207 publications with PECAM-1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >186 publications with PECAM-1 and Lung Neoplasms
 Liver Diseases Antibodies  >172 publications with PECAM-1 and Liver Diseases
 Atherosclerosis Antibodies  >144 publications with PECAM-1 and Atherosclerosis

Organs/Tissues associated with PECAM-1 active protein

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >3391 publications with PECAM-1 and Vascular
 Blood Antibodies  >2990 publications with PECAM-1 and Blood
 Muscle Antibodies  >682 publications with PECAM-1 and Muscle
 Embryonic Tissue Antibodies  >509 publications with PECAM-1 and Embryonic Tissue
 Lung Antibodies  >428 publications with PECAM-1 and Lung
 Heart Antibodies  >347 publications with PECAM-1 and Heart
 Skin Antibodies  >337 publications with PECAM-1 and Skin
 Brain Antibodies  >322 publications with PECAM-1 and Brain
 Connective Tissue Antibodies  >243 publications with PECAM-1 and Connective Tissue
 Kidney Antibodies  >234 publications with PECAM-1 and Kidney
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