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PLGF-3 Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695730

PLGF-3 is an angiogenic factor that belongs to the cysteine-knot superfamily of growth factors. PLGF-3 is expressed exclusively in the placenta. It signals through the VEGFR-1/FLT1 receptor and stimulates endothelial cell proliferation and migration. PLGF-3… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PLGF-3, Active Protein
Full Product Name
Human PLGF-3
Product Gene Name
PLGF-3 active protein
Product Synonym Names
Recombinant Human PLGF-3
Sequence
LPAVPPQQW ALSAGNGSS EVEVVPFQE VWGRSYCRA LERLVDVVS EYPSEVEHM FSPSCVSLL RCTGCCGDE NLHCVPVET ANVTMQLLK IRSGDRPSY VELTFSQHV RCECRHSPG RQSPDMPGD FRADAPSFL PPRRSLPML FRMEWGCAL TGSQSAVWP SSPVPEEIP RMHPGRNGK KQQRKPLRE KMKPERCGD AVPRR
Host
E Coli
Species Reactivity
Species Reactivity: Human
Purity/Purification
Above 95% as determined by SDS-PAGE Analysis.
Preparation and Storage
At -20 degree C
Molecular Weight
19,338 Da
OMIM
601121
3D Structure
ModBase 3D Structure for P49763
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Determined by its ability to chemoattract human monocytes using a concentration range of 5.0-50.0 ng/ml.
Cell Type
Endothelial Cells

Product Categories/Family for PLGF-3 active protein

Cancer; Angiogenesis; Inflammation; Proliferation and Cell Cycle

Testing Data of PLGF-3 active protein

Human PLGF-3 Active Protein – Cat# MBS695730

Other Notes

Small volumes of PLGF-3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLGF-3 purchase

MBS695730 is an active protein targeting PLGF-3. Also known as Human PLGF-3. Reactive in Species Reactivity: Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PLGF-3. It may not necessarily be applicable to this product.

NCBI GI #
17380553
NCBI GeneID
5228
NCBI Accession #
P49763.2
UniProt Primary Accession #
P49763
UniProt Secondary Accession #
Q07101; Q9BV78; Q9Y6S8
UniProt Related Accession #
P49763
NCBI Official Full Name
Placenta growth factor
NCBI Official Synonym Full Names
placental growth factor
NCBI Official Symbol
PGF
NCBI Official Synonym Symbols
PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760
UniProt Protein Name
Placenta growth factor
UniProt Gene Name
PGF
UniProt Synonym Gene Names
PGFL; PLGF; PlGF
UniProt Entry Name
PLGF_HUMAN
NCBI Protein Information
placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein

NCBI Summary for PLGF-3

This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

UniProt Comments for PLGF-3

PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function: heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity

Biological Process: response to drug; organ regeneration; female pregnancy; signal transduction; cellular response to hormone stimulus; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation
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Research Articles on PLGF-3

1. Healthy women have lower serum and placental levels of PlGF compared to overt diabetics or women with gestational diabetes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PLGF-3 active protein

 Reference Product  PubMed Publications
 VEGFA active protein  >24 publications with PLGF-3 and VEGFA
 FLT1 active protein  >19 publications with PLGF-3 and FLT1
 KDR active protein  >13 publications with PLGF-3 and KDR
 EDN1 active protein  >5 publications with PLGF-3 and EDN1
 NRP1 active protein  >4 publications with PLGF-3 and NRP1
 FLT4 active protein  >3 publications with PLGF-3 and FLT4
 AKT1 active protein  >2 publications with PLGF-3 and AKT1
 PIK3CA active protein  >1 publications with PLGF-3 and PIK3CA

Pathways associated with PLGF-3 active protein

 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with PLGF-3 active protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >383 publications with PLGF-3 and Cardiovascular Diseases
 Inflammation Antibodies  >285 publications with PLGF-3 and Inflammation
 Hypertension Antibodies  >194 publications with PLGF-3 and Hypertension
 Disease Models, Animal Antibodies  >159 publications with PLGF-3 and Disease Models, Animal
 Necrosis Antibodies  >154 publications with PLGF-3 and Necrosis
 Lung Diseases Antibodies  >128 publications with PLGF-3 and Lung Diseases
 Heart Diseases Antibodies  >127 publications with PLGF-3 and Heart Diseases
 Atherosclerosis Antibodies  >93 publications with PLGF-3 and Atherosclerosis
 Brain Diseases Antibodies  >72 publications with PLGF-3 and Brain Diseases
 Kidney Diseases Antibodies  >69 publications with PLGF-3 and Kidney Diseases

Organs/Tissues associated with PLGF-3 active protein

 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >767 publications with PLGF-3 and Ovary
 Uterus Antibodies  >732 publications with PLGF-3 and Uterus
 Muscle Antibodies  >506 publications with PLGF-3 and Muscle
 Heart Antibodies  >251 publications with PLGF-3 and Heart
 Lung Antibodies  >238 publications with PLGF-3 and Lung
 Kidney Antibodies  >212 publications with PLGF-3 and Kidney
 Placenta Antibodies  >209 publications with PLGF-3 and Placenta
 Embryonic Tissue Antibodies  >198 publications with PLGF-3 and Embryonic Tissue
 Brain Antibodies  >195 publications with PLGF-3 and Brain
 Liver Antibodies  >134 publications with PLGF-3 and Liver
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