Mouse MCP-5 Active Protein – Cat# MBS695754

MCP-5 Mouse Active Protein

Name: MCP-5 Active Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS695754
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695754

The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MCP-5, Active Protein

Full Product Name

Murine MCP-5 (CCL12)

Product Gene Name

MCP-5 active protein

Product Synonym Gene Name

CCL12

Product Synonym Names

Recombinant Murine MCP-5 (CCL12)

Sequence

GPDAVSTPV TCCYNVVKQ KIHVRKLKS YRRITSSQC PREAVIFRT ILDKEICAD PKEKWVKNS INHLDKTSQ TFILEPSCL G

Host

E Coli

Species Reactivity

Species Reactivity: Mouse
Cross Reactivity: Human

Purity/Purification

Above 98% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

11,659 Da

3D Structure

ModBase 3D Structure for Q62401

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-50.0 ng/ml.

Cell Type

Monocytes and Macrophages, NK and NKT Cells, T Cells, Dendritic Cells

Product Categories/Family for MCP-5 active protein

Innate Immunity; Adaptive Immunity; Cancer; Neurosciences; Inflammation; Chemotaxis

Other Notes

Small volumes of MCP-5 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCP-5 purchase

MBS695754 is an active protein targeting MCP-5. Also known as Murine MCP-5 (CCL12). Reactive in Species Reactivity: Mouse
Cross Reactivity: Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MCP-5. It may not necessarily be applicable to this product.

NCBI GI #

2493663

NCBI GeneID

102641905

NCBI Accession #

Q62401.1

UniProt Primary Accession #

Q62401

UniProt Secondary Accession #

Q9QYD6

NCBI Official Full Name

C-C motif chemokine 12

NCBI Official Symbol

LOC102641905

UniProt Protein Name

C-C motif chemokine 12

UniProt Synonym Protein Names

MCP-1-related chemokine; Monocyte chemoattractant protein 5; Monocyte chemotactic protein 5; MCP-5; Small-inducible cytokine A12

Protein Family

C-C motif chemokine

UniProt Gene Name

Ccl12

UniProt Synonym Gene Names

Mcp5; Scya12; MCP-5

UniProt Entry Name

CCL12_MOUSE

NCBI Protein Information

c-C motif chemokine 12-like

UniProt Comments for MCP-5

CCL2: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine; Secreted

Cellular Component: extracellular space; extracellular region; intracellular

Molecular Function: chemokine activity; CCR2 chemokine receptor binding; cytokine activity

Biological Process: cytokine and chemokine mediated signaling pathway; positive regulation of leukocyte migration; MAPKKK cascade; cytoskeleton organization and biogenesis; chemotaxis; macrophage chemotaxis; regulation of cell shape; monocyte chemotaxis; protein kinase B signaling cascade; lipopolysaccharide-mediated signaling pathway; immune response; negative regulation of neuron apoptosis; angiogenesis; inflammatory response; astrocyte cell migration

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.