VAP-1 Human Active Protein

This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

AOC3: Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis. Belongs to the copper/topaquinone oxidase family.

Protein type: Membrane protein, integral; Cell adhesion; EC 1.4.3.21; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Oxidoreductase; Amino Acid Metabolism - glycine, serine and threonine; Other Amino Acids Metabolism - beta-alanine

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cell surface; microvillus; cytoplasm; integral to membrane; plasma membrane

Molecular Function: amine oxidase activity; protein binding; copper ion binding; protein homodimerization activity; protein heterodimerization activity; calcium ion binding; cation channel activity; quinone binding

Biological Process: response to antibiotic; amine metabolic process; cell adhesion; inflammatory response; cation transport