Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Human Active Protein

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

TRAIL-R2: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Homotrimer. Can interact with TRADD and RIPK1. Regulated by p53/TP53. Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: cell surface; integral component of membrane; integral component of plasma membrane; intracellular; plasma membrane

Molecular Function: protein binding; receptor activity; TRAIL binding; tumor necrosis factor-activated receptor activity

Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of NF-kappaB-inducing kinase; apoptosis; cell surface receptor signaling pathway; immune response; induction of apoptosis via death domain receptors; inflammatory response; leukocyte migration; multicellular organism development; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway

Disease: Squamous Cell Carcinoma, Head And Neck