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Fibroblast Growth Factor 10 (FGF10) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2124245
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MBS2124245 is an active protein targeting FGF10. Also known as Active Fibroblast Growth Factor 10 (FGF10). Host: E Coli. More details

$205 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Fibroblast Growth Factor 10 (FGF10), Active Protein
Full Product Name
Active Fibroblast Growth Factor 10 (FGF10)
Product Gene Name
FGF10 active protein
Product Synonym Names
Fibroblast Growth Factor 10; Keratinocyte growth factor 2
Sequence
Gln38~Ser2 08
Host
E Coli
Form/Format
Freeze-dried powder
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Purity/Purification
>90%
Preparation and Storage
Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Molecular Weight
23,436 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (44305097..44388784, complement). Location: 5p13-p12
OMIM
149730
3D Structure
ModBase 3D Structure for O15520
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Source
Prokaryotic expression
Species
Human
Tag
N-terminal His Tag
Isoelectric Point
10
Usage
Reconstitute in 20mM Tris, 150mM NaCl (PH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Product Categories/Family for FGF10 active protein

Cytokine; Tumor immunity; Infection immunity; Dermatology; Active proteins/AP
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for FGF10 active protein
Cell Culture, Activity Assay

Sequence Information of FGF10 active protein

FGF10 Active Protein – Cat# MBS2124245

Gene Sequence of FGF10 active protein

Figure. Gene Sequencing (extract)
FGF10 Active Protein, Gene Sequence – Cat# MBS2124245

SDS-Page of FGF10 active protein

Figure. SDS-PAGE
FGF10 Active Protein, SDS-Page – Cat# MBS2124245

Other Notes

Small volumes of FGF10 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF10. It may not necessarily be applicable to this product.

NCBI GI #
4758360
NCBI GeneID
2255
NCBI Accession #
NP_004456.1
UniProt Primary Accession #
O15520
UniProt Secondary Accession #
Q6FHT6; Q96P59
UniProt Related Accession #
O15520
GenBank Nucleotide #
NM_004465.1
NCBI Official Full Name
fibroblast growth factor 10
NCBI Official Synonym Full Names
fibroblast growth factor 10
NCBI Official Symbol
FGF10
UniProt Protein Name
Fibroblast growth factor 10
UniProt Synonym Protein Names
Keratinocyte growth factor 2
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF10
UniProt Synonym Gene Names
FGF-10
UniProt Entry Name
FGF10_HUMAN
NCBI Protein Information
fibroblast growth factor 10; FGF-10; keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria

NCBI Summary for FGF10

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
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UniProt Comments for FGF10

FGF10: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Belongs to the heparin-binding growth factors family.

Protein type: Cell development/differentiation; Cytokine; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5p13-p12

Cellular Component: extracellular matrix; extracellular space; cell surface; plasma membrane; extracellular region; nucleus

Molecular Function: heparin binding; protein binding; growth factor activity; type 2 fibroblast growth factor receptor binding; fibroblast growth factor receptor binding; chemoattractant activity

Biological Process: nerve growth factor receptor signaling pathway; salivary gland development; urothelial cell proliferation; somatic stem cell maintenance; activation of MAPK activity; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of transcription, DNA-dependent; muscle cell fate commitment; response to lipopolysaccharide; regulation of saliva secretion; embryonic pattern specification; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; positive regulation of fibroblast proliferation; epithelial cell proliferation; positive chemotaxis; embryonic digestive tract morphogenesis; induction of an organ; mesonephros development; embryonic genitalia morphogenesis; positive regulation of keratinocyte migration; spleen development; positive regulation of DNA repair; fibroblast growth factor receptor signaling pathway; positive regulation of urothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; branching morphogenesis of a tube; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; metanephros development; positive regulation of epithelial cell proliferation; wound healing; radial glial cell differentiation; positive regulation of mitotic cell cycle; response to estradiol stimulus; positive regulation of vascular endothelial growth factor receptor signaling pathway; induction of positive chemotaxis; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; establishment of mitotic spindle orientation; positive regulation of lymphocyte proliferation; tissue regeneration; male genitalia morphogenesis; pancreas development; thyroid gland development; lacrimal gland development; angiogenesis; otic vesicle formation; female genitalia morphogenesis; positive regulation of Notch signaling pathway; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; hair follicle morphogenesis; thymus development; keratinocyte proliferation; regulation of activin receptor signaling pathway; embryonic camera-type eye development; odontogenesis of dentine-containing teeth; limb bud formation; pituitary gland development; positive regulation of ATPase activity; actin cytoskeleton reorganization; white fat cell differentiation; insulin receptor signaling pathway; innate immune response; blood vessel remodeling; positive regulation of Ras protein signal transduction; positive regulation of DNA replication; regulation of smoothened signaling pathway

Disease: Lacrimoauriculodentodigital Syndrome; Aplasia Of Lacrimal And Salivary Glands
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Research Articles on FGF10

1. The sclera of myopic eyes had higher FGF10 levels. The risk G allele of SNP rs339501 was associated with extreme myopia in human and caused a higher gene expression in the luciferase assay.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF10 active protein

 Reference Product  PubMed Publications
 FGFR2 active protein  >157 publications with FGF10 and FGFR2
 SHH active protein  >92 publications with FGF10 and SHH
 BMP4 active protein  >83 publications with FGF10 and BMP4
 FGFR1 active protein  >48 publications with FGF10 and FGFR1
 FGF1 active protein  >40 publications with FGF10 and FGF1
 FGF9 active protein  >37 publications with FGF10 and FGF9
 FGF4 active protein  >31 publications with FGF10 and FGF4
 TBX4 active protein  >14 publications with FGF10 and TBX4
 PTF1A active protein  >4 publications with FGF10 and PTF1A
 ONECUT1 active protein  >1 publications with FGF10 and ONECUT1

Pathways associated with FGF10 active protein

 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram

Diseases associated with FGF10 active protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >32 publications with FGF10 and Disease Models, Animal
 Cleft Palate Antibodies  >27 publications with FGF10 and Cleft Palate
 Lung Diseases Antibodies  >19 publications with FGF10 and Lung Diseases
 Genital Diseases, Male Antibodies  >18 publications with FGF10 and Genital Diseases, Male
 Inflammation Antibodies  >16 publications with FGF10 and Inflammation
 Prostatic Diseases Antibodies  >13 publications with FGF10 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >12 publications with FGF10 and Prostatic Neoplasms
 Heart Defects, Congenital Antibodies  >12 publications with FGF10 and Heart Defects, Congenital
 Skin Diseases Antibodies  >11 publications with FGF10 and Skin Diseases
 Heart Diseases Antibodies  >10 publications with FGF10 and Heart Diseases

Organs/Tissues associated with FGF10 active protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >49 publications with FGF10 and Muscle
 Brain Antibodies  >39 publications with FGF10 and Brain
 Intestine Antibodies  >32 publications with FGF10 and Intestine
 Kidney Antibodies  >24 publications with FGF10 and Kidney
 Trachea Antibodies  >17 publications with FGF10 and Trachea
 Uterus Antibodies  >7 publications with FGF10 and Uterus
 Mixed Antibodies  >4 publications with FGF10 and Mixed
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