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Grobeta / MIP-2 (GRO-beta/MIP-2) Rat Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695835

All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO-beta/MIP-2 is a 7.9 kDa protein consisting of 73 amino acids including… More details

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Product Overview

Product Name
GRObeta / MIP-2 (GRO-beta/MIP-2), Active Protein
Full Product Name
Rat GRObeta / MIP-2 (CXCL2)
Product Gene Name
GRO-beta/MIP-2 active protein
Product Synonym Gene Name
CXCL2
Product Synonym Names
Recombinant Rat GRO-beta/MIP-2 (CXCL2)
Sequence
VVVASELRC QCLTTLPRV DFKNIQSLT VTPPGPHCA QTEVIATLK DGHEVCLNP EAPLVQRIV QKILNKGKA N
Host
E Coli
Species Reactivity
Species Reactivity: Rat
Cross Reactivity: Human, Mouse
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Preparation and Storage
At -20 degree C
Molecular Weight
10,783 Da
3D Structure
ModBase 3D Structure for P30348
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Determined by its ability to chemoattract rat neutrophils using a concentration range of 10.0-100.0 ng/ml.

Product Categories/Family for GRO-beta/MIP-2 active protein

Angiogenesis; Neurosciences; Inflammation; Chemotaxis

Other Notes

Small volumes of GRO-beta/MIP-2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRO-beta/MIP-2 purchase

MBS695835 is an active protein targeting GRO-beta/MIP-2. Also known as Rat GRObeta / MIP-2 (CXCL2). Reactive in Species Reactivity: Rat
Cross Reactivity: Human, Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GRO-beta/MIP-2. It may not necessarily be applicable to this product.

NCBI GI #
266536
NCBI GeneID
114105
NCBI Accession #
P30348.1
UniProt Primary Accession #
P30348
UniProt Secondary Accession #
Q5WA60
UniProt Related Accession #
P30348
NCBI Official Full Name
C-X-C motif chemokine 2
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 2
NCBI Official Symbol
Cxcl2
NCBI Official Synonym Symbols
Mip-2; Scyb2
UniProt Protein Name
C-X-C motif chemokine 2
UniProt Synonym Protein Names
Cytokine-induced neutrophil chemoattractant 3; CINC-3; Macrophage inflammatory protein 2; MIP2
UniProt Gene Name
Cxcl2
UniProt Synonym Gene Names
Cinc3; Mip-2; Mip2; Scyb2; CINC-3; MIP2
UniProt Entry Name
CXCL2_RAT
NCBI Protein Information
C-X-C motif chemokine 2; MIP2; CINC-3; macrophage inflammatory protein 2; small inducible cytokine subfamily, member 2; cytokine-induced neutrophil chemoattractant 3

NCBI Summary for GRO-beta/MIP-2

chemokine involved in the pulmonary inflammatory response [RGD, Feb 2006]

UniProt Comments for GRO-beta/MIP-2

CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: neutrophil chemotaxis; wound healing; leukocyte chemotaxis; response to glucocorticoid stimulus; response to amphetamine; positive regulation of leukocyte chemotaxis; response to estradiol stimulus; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to heat; response to molecule of bacterial origin; response to gamma radiation; immune response; inflammatory response
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Research Articles on GRO-beta/MIP-2

1. IL-1beta-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic beta-cells requires stimulus-induced changes in histone chemical modifications, recruitment of the NF-kappaB and STAT1 transcription factors to genomic regulatory sequences within the proximal gene promoters, and increases in phosphorylated forms of RNA polymerase II.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GRO-beta/MIP-2 active protein

 Reference Product  PubMed Publications
 Cxcl1 active protein  >557 publications with GRO-beta/MIP-2 and Cxcl1
 Ccl2 active protein  >373 publications with GRO-beta/MIP-2 and Ccl2
 Il8rb active protein  >117 publications with GRO-beta/MIP-2 and Il8rb
 Cxcl3 active protein  >99 publications with GRO-beta/MIP-2 and Cxcl3
 Cxcr4 active protein  >44 publications with GRO-beta/MIP-2 and Cxcr4
 Ccr2 active protein  >42 publications with GRO-beta/MIP-2 and Ccr2
 Cxcl6 active protein  >36 publications with GRO-beta/MIP-2 and Cxcl6
 Ccr1 active protein  >25 publications with GRO-beta/MIP-2 and Ccr1
 Cxcr3 active protein  >18 publications with GRO-beta/MIP-2 and Cxcr3
 Ppbp active protein  >3 publications with GRO-beta/MIP-2 and Ppbp

Pathways associated with GRO-beta/MIP-2 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 PI3K_AKT_NFKB Pathway antibodies  PI3K_AKT_NFKB Pathway Diagram

Diseases associated with GRO-beta/MIP-2 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1008 publications with GRO-beta/MIP-2 and Inflammation
 Necrosis Antibodies  >643 publications with GRO-beta/MIP-2 and Necrosis
 Lung Diseases Antibodies  >383 publications with GRO-beta/MIP-2 and Lung Diseases
 Disease Models, Animal Antibodies  >355 publications with GRO-beta/MIP-2 and Disease Models, Animal
 Lung Injury Antibodies  >259 publications with GRO-beta/MIP-2 and Lung Injury
 Pneumonia Antibodies  >173 publications with GRO-beta/MIP-2 and Pneumonia
 Reperfusion Injury Antibodies  >115 publications with GRO-beta/MIP-2 and Reperfusion Injury
 Wounds and Injuries Antibodies  >95 publications with GRO-beta/MIP-2 and Wounds and Injuries
 Edema Antibodies  >92 publications with GRO-beta/MIP-2 and Edema
 Skin Diseases Antibodies  >81 publications with GRO-beta/MIP-2 and Skin Diseases

Organs/Tissues associated with GRO-beta/MIP-2 active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >624 publications with GRO-beta/MIP-2 and Lung
 Connective Tissue Antibodies  >28 publications with GRO-beta/MIP-2 and Connective Tissue
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