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Fractalkine (CX3CL1) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695867

Fractalkine is a CX3CL chemokine that signals through the CX3CR1 receptor. Fractalkine has been shown to chemoattract monocytes, microglia cells and NK cells. Recombinant human Fractalkine is an 8.5 kDa protein containing 76 amino acid residues, including the… More details

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Product Overview

Product Name
Fractalkine (CX3CL1), Active Protein
Full Product Name
Human Fractalkine (CX3CL1)
Product Gene Name
CX3CL1 active protein
Product Synonym Names
Recombinant Human Fractalkine (CX3CL1)
Sequence
QHHGVTKCN ITCSKMTSK IPVALLIHY QQNQASCGK RAIILETRQ HRLFCADPK EQWVKDAMQ HLDRQAAAL TRNG
Host
E Coli
Species Reactivity
Species Reactivity: Human
Cross Reactivity: Monkey, Mouse, Rat
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Preparation and Storage
At -20 degree C
Molecular Weight
42,203 Da
OMIM
601880
3D Structure
ModBase 3D Structure for P78423
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Determined by its ability to chemoattract human T cells using a concentration range of 5.0-10.0 ng/ml.
Cell Type
Monocytes and Macrophages, NK and NKT Cells

Product Categories/Family for CX3CL1 active protein

Innate Immunity; Apoptosis; Cancer; Angiogenesis; Neurosciences; Inflammation; Chemotaxis

Other Notes

Small volumes of CX3CL1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CX3CL1 purchase

MBS695867 is an active protein targeting CX3CL1. Also known as Human Fractalkine (CX3CL1). Reactive in Species Reactivity: Human
Cross Reactivity: Monkey, Mouse, Rat. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CX3CL1. It may not necessarily be applicable to this product.

NCBI GI #
6175080
NCBI GeneID
6376
NCBI Accession #
P78423.1
UniProt Primary Accession #
P78423
UniProt Secondary Accession #
O00672
UniProt Related Accession #
P78423
NCBI Official Full Name
Fractalkine
NCBI Official Synonym Full Names
chemokine (C-X3-C motif) ligand 1
NCBI Official Symbol
CX3CL1
NCBI Official Synonym Symbols
NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin
UniProt Protein Name
Fractalkine
UniProt Synonym Protein Names
C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1Cleaved into the following chain:Processed fractalkine
Protein Family
Fractalkine
UniProt Gene Name
CX3CL1
UniProt Synonym Gene Names
FKN; NTT; SCYD1
UniProt Entry Name
X3CL1_HUMAN
NCBI Protein Information
fractalkine; C-X3-C motif chemokine 1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)

UniProt Comments for CX3CL1

CX3CL1: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Belongs to the intercrine delta family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: extracellular space; cell surface; extracellular region; plasma membrane; integral to membrane

Molecular Function: protein binding; chemokine activity; receptor binding

Biological Process: positive regulation of transforming growth factor-beta1 production; neutrophil chemotaxis; cytokine and chemokine mediated signaling pathway; leukocyte chemotaxis; defense response; chemotaxis; angiogenesis involved in wound healing; leukocyte adhesive activation; macrophage chemotaxis; positive regulation of angiogenesis; positive regulation of calcium-independent cell-cell adhesion; immune response; cell adhesion; lymphocyte chemotaxis; positive regulation of inflammatory response
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Research Articles on CX3CL1

1. A significant and persistent decrease in circulating fractalkine was observed after orthopedic and coronary bypass surgery despite a marked inflammatory response.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CX3CL1 active protein

 Reference Product  PubMed Publications
 CX3CR1 active protein  >470 publications with CX3CL1 and CX3CR1
 CCR2 active protein  >54 publications with CX3CL1 and CCR2
 CXCR4 active protein  >35 publications with CX3CL1 and CXCR4
 CCR5 active protein  >35 publications with CX3CL1 and CCR5
 CXCR3 active protein  >26 publications with CX3CL1 and CXCR3
 CCR1 active protein  >17 publications with CX3CL1 and CCR1
 CCR3 active protein  >12 publications with CX3CL1 and CCR3
 CXCR6 active protein  >11 publications with CX3CL1 and CXCR6

Pathways associated with CX3CL1 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with CX3CL1 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >325 publications with CX3CL1 and Inflammation
 Necrosis Antibodies  >175 publications with CX3CL1 and Necrosis
 Cardiovascular Diseases Antibodies  >140 publications with CX3CL1 and Cardiovascular Diseases
 Brain Diseases Antibodies  >91 publications with CX3CL1 and Brain Diseases
 Atherosclerosis Antibodies  >85 publications with CX3CL1 and Atherosclerosis
 Pain Antibodies  >56 publications with CX3CL1 and Pain
 Kidney Diseases Antibodies  >55 publications with CX3CL1 and Kidney Diseases
 Liver Diseases Antibodies  >46 publications with CX3CL1 and Liver Diseases
 Heart Diseases Antibodies  >45 publications with CX3CL1 and Heart Diseases
 Myocardial Ischemia Antibodies  >37 publications with CX3CL1 and Myocardial Ischemia

Organs/Tissues associated with CX3CL1 active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >178 publications with CX3CL1 and Brain
 Muscle Antibodies  >90 publications with CX3CL1 and Muscle
 Kidney Antibodies  >83 publications with CX3CL1 and Kidney
 Lung Antibodies  >80 publications with CX3CL1 and Lung
 Liver Antibodies  >61 publications with CX3CL1 and Liver
 Heart Antibodies  >59 publications with CX3CL1 and Heart
 Nerve Antibodies  >48 publications with CX3CL1 and Nerve
 Skin Antibodies  >41 publications with CX3CL1 and Skin
 Intestine Antibodies  >32 publications with CX3CL1 and Intestine
 Eye Antibodies  >26 publications with CX3CL1 and Eye
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